Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants

Sadeer, Nabeelah Bibi; Llorent‐Martínez, Eulogio J.; Béné, Kouadio; Mahomoodally, Mohamad Fawzi; Mollica, Adriano; Sinan, Kouadio Ibrahime; Stefanucci, Azzurra; Ruiz-Riaguas, A.; Córdova, M.L. Fernández-de; Zengin, Gökhan

doi:10.1016/j.jpba.2019.05.041

Cited by 66 publications

(26 citation statements)

References 21 publications

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“…Antioxidants, commonly known as free radical scavenger, peroxide decomposer, metal chelator, singlet oxygen quencher or electron donor are necessary for protecting the body against several chronic health diseases/disorders such as cardiovascular diseases, diabetes, cancers, Alzheimer's disease, etc. Although synthetic antioxidants can prevent or attenuate risk of oxidative stress both in vitro and in vivo [34,35] but exploration of natural antioxidants is an emerging trend to potentiate antioxidative defense mechanism with minimum side effects. [35] There are several different methods that can be used to investigate antioxidant potential of natural antioxidants including beverages, foods and plant extracts, but the most commonly used methods are DPPH radical scavenging and TAP assay.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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UHPLC-QTOF-MS/MS metabolites profiling and antioxidant/antidiabetic attributes of Cuscuta reflexa grown on Casearia tomentosa: exploring phytochemicals role via molecular docking

Nadeem

Mumtaz

Danish

et al. 2020

International Journal of Food Properties

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Present study reports metabolites profiling, antioxidant, and antidiabetic effects of Cuscuta reflexa grown on Casearia tomentosa. The UHPLC-QTOF-MS/MS method was used to characterize phytochemicals in most potent extract. Thirteen bioactive compounds/metabolites including (2S)-3-(β-D-galactopyranosyloxy)-2-(hexanoyloxy)propyl nonanoate, 4-O-β-D-glucosyl-4-coumaric acid, isorhamnetin-3-O-glucoside, 7-(α-D-glucopyranosyloxy)-2,3,4,5,6-pentahydroxyheptanoic acid, 13Shydroxyoctadecadienoic acid, astragaloside derivative, salicylic acid, oleanolic acid, citric acid, pinellic acid, quinic acid, caffeic acid derivative and caffeic acid-3-glucoside were detected in 80% hydroethanolic (HE) extract. Among different extracts (aqueous, 20-80% HE and pure ethanolic), 80% HE extract showed maximum TPC (186.19 ± 2.15 mg GAE/g DE) and TFC (106.50 ± 1.68 mg RE/g DE). A strong correlation was observed between TPC, TFC, DPPH radical scavenging (IC 50 = 60.64 ± 1.74 µg/mL) and TAP activity (235.96 ± 1.33 mg AAE/g DE) of 80% HE extract among others. The same extract also depicted highest α-amylase and α-glucosidase enzyme inhibition with IC 50 of 71.84 ± 1.06 and 57.25 ± 1.40 µg/mL, respectively. Molecular docking was performed to explore possible role of identified phytochemicals. Binding affinity data as well as interaction patterns have revealed possible interaction of the identified bioactives against α-glucosidase and α-amylase. Moreover, intra-molecular charge transfer, energies of the FMOs, HOMO-LUMO-E gaps , MEP and IP were also explained. The present findings suggested that, C. reflexa is a promising natural antioxidant and antidiabetic agent, thus supporting the use of this plant for designing related functional foods and nutra-pharmaceuticals.

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Section: Antioxidant Activitymentioning

confidence: 99%

“…In literature, the synergistic role of identified bioactive constituents of the plant extracts via enzyme inhibition has been explored by using docking studies. [34,69] Hence, we also performed docking studies by using MOE. Role of the constituent was determined by computing binding affinities.…”

Section: Docking Studiesmentioning

confidence: 99%

UHPLC-QTOF-MS/MS metabolites profiling and antioxidant/antidiabetic attributes of Cuscuta reflexa grown on Casearia tomentosa: exploring phytochemicals role via molecular docking

Nadeem

Mumtaz

Danish

et al. 2020

International Journal of Food Properties

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“…However, this rather temporary and non-selective approach and the current advances in pharmaceutical sciences determined an increased interest for new and performance-enhanced formulations. The intrinsic medicinal properties of phytochemicals have been acknowledged for a long period of time [1,2], but the interest for such natural-derived bioactive substances has lately grown considerably [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

MAPLE Coatings Embedded with Essential Oil-Conjugated Magnetite for Anti-Biofilm Applications

et al. 2021

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The present study reports on the development and evaluation of nanostructured composite coatings of polylactic acid (PLA) embedded with iron oxide nanoparticles (Fe3O4) modified with Eucalyptus (Eucalyptus globulus) essential oil. The co-precipitation method was employed to synthesize the magnetite particles conjugated with Eucalyptus natural antibiotic (Fe3O4@EG), while their composition and microstructure were investigated using grazing incidence X-ray diffraction (GIXRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and dynamic light scattering (DLS). The matrix-assisted pulsed laser evaporation (MAPLE) technique was further employed to obtain PLA/Fe3O4@EG thin films. Optimal experimental conditions for laser processing were established by complementary infrared microscopy (IRM) and scanning electron microscopy (SEM) investigations. The in vitro biocompatibility with eukaryote cells was proven using mesenchymal stem cells, while the anti-biofilm efficiency of composite PLA/Fe3O4@EG coatings was assessed against Gram-negative and Gram-positive pathogens.

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“…Synthetics chemicals have been decided as toxic or carcinogenic (Da Cruz et al 2019). From that prospect, the search of active constituents from medicinal plants to replace synthetic ones is one of the most attractive avenues in an endeavor to develop new drug regimen; that plants need to be investigated for detect of active components (Sadeer et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Growth and chemical profile of clary sage (Salvia sclarea L.) in response to algae and banana peel extracts

et al. 2020

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Background Clary sage (Salvia sclarea L.) has anti-inflammatory and anti-microbial properties; its seeds were imported from Germany for cultivation and acclimatization under the Egyptian environmental conditions as a new source of natural products. Solutions of alga and banana peel waste considered as a source of plant nutrition; it contains some bio-regulators and minerals. This research paper aimed to evaluate growth (fresh and dry weights) and chemical composition (free radical-scavenging activity, carbohydrates, flavonoids, phenols and phenolic compounds) under foliar spray of algae solution (ALS) and the extract of banana peel waste (BPW). Results The highest values of fresh and dry weights were detected with the treatment of 1.5 g/l (BPW) × 1.5 g/l (ALS). The maximum inhibition of free radical -cavenging activity was recorded at 1 g/l (ALS) × 0.5 g/l (BPW). 2 g/l (ALS) without BPW treatment resulted in the greatest amounts of total carbohydrates. The greatest accumulation of total flavonoids was obtained from the plants treated with 0.5 g/l (BPW) × 1 g/l (ALS). Plants exposed to 1.5 g/l (BPW) with 2 g/l (ALS) gave the greatest accumulation of total phenols. Phenolic compounds that were detected by HPLC analysis were changed due to ALS, BPW, and their interactions. Conclusion Different variations were observed in growth characters and various chemical constituents of Clary sage under the application of ALS and/or BPW. This research will help farmers to produce medicinal and aromatic plants by using cheap and environmentally friendly methods.

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Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants

Cited by 66 publications

References 21 publications

UHPLC-QTOF-MS/MS metabolites profiling and antioxidant/antidiabetic attributes of Cuscuta reflexa grown on Casearia tomentosa: exploring phytochemicals role via molecular docking

UHPLC-QTOF-MS/MS metabolites profiling and antioxidant/antidiabetic attributes of Cuscuta reflexa grown on Casearia tomentosa: exploring phytochemicals role via molecular docking

MAPLE Coatings Embedded with Essential Oil-Conjugated Magnetite for Anti-Biofilm Applications

Growth and chemical profile of clary sage (Salvia sclarea L.) in response to algae and banana peel extracts

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