Chemical profiling, in vitro biological activities and Pearson correlation between phenolic contents and antioxidant activities of Caragana brachyantha Rech.f

Ali, Liaquat; Khan, Shakeel Ahmad; Nazir, Mamona; Raiz, Naheed; Naz, Saima; Zengin, Gökhan; Mukhtar, Mahreen; Parveen, Sajida; Shazmeen, Natasha; Saleem, Muhammad; Tareen, Rasool Baksh

doi:10.1016/j.sajb.2021.04.009

Cited by 14 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High correlation values (R > 0.8) were observed between the total phenolics' content and the results in most of the aforementioned assays. In agreement with our findings, several researchers reported strong correlation values between these assays in plant extracts [27,56,57]. However, we observed a low correlation value for PBD assay, and this fact could be explained by the presence in the extracts of other reducing molecules (peptides, sugars, etc.).…”

Section: Antioxidant Propertiessupporting

confidence: 91%

“…Mentha spicata is one of the most common species in the genus Mentha, and several publications have acknowledged its biological and chemical potential [1]. Mentha spicata is a perennial herbaceous plant of great interest in the folk medicine system [1], especially for treating gastrointestinal disorders [7,[26][27][28]. Other traditional ethnopharmacological uses include the treatment of respiratory disorders [29] and diabetes [30].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Zengin

Ceylan

et al. 2022

Plants

Self Cite

View full text Add to dashboard Cite

Mentha spicata is one of the most popular species in the genus, and it is of great interest as a gastrointestinal and sedative agent in the folk medicine system. In this study, different M. spicata extracts, obtained by the use of four solvents (hexane, chloroform, acetone and acetone/water) were chemically characterized using HPLC-ESI-MS n, which allowed for identification of 27 phenolic compounds. The extracts’ antioxidant and enzyme inhibitory properties were investigated. In addition, neuroprotective effects were evaluated in hypothalamic HypoE22 cells, and the ability of the extracts to prevent the hydrogen peroxide-induced degradation of dopamine and serotonin was observed. The best antioxidant effect was achieved for all the extraction methods using acetone/water as a solvent. These extracts were the richest in acacetin, eriodictyol, hesperidin, sagerinic acid, naringenin, luteolin, chlorogenic acid, chrysoeriol and apigenin. The intrinsic antioxidant and enzyme inhibition properties of the acetone/water extract could also explain, albeit partially, its efficacy in preventing prostaglandin E2 overproduction and dopamine depletion (82.9% turnover reduction) in HypoE22 cells exposed to hydrogen peroxide. Thus, our observations can provide a scientific confirmation of the neuromodulatory and neuroprotective effects of M. spicata.

show abstract

Section: Antioxidant Propertiessupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Zengin

Ceylan

et al. 2022

Plants

Self Cite

View full text Add to dashboard Cite

show abstract

“…These three different assays also exhibited significant correlation between each other. The linear correlation between phenolics and flavonoid contents with radical scavenging activity and reducing power in plant material was reported previously [46]. The correlation coefficient of NO production ratio, a biomarker of inflammation response, with other factors were not significant and this demonstrated the absence of linear correlation with them.…”

Section: Pearson's Correlation Coefficientsupporting

confidence: 70%

Antioxidant, α-Glucosidase Inhibitory, and Anti-Inflammatory Activities and Cell Toxicity of Waxy and Normal Wheat Sprouts at Various Germination Time

Han

2021

Applied Sciences

View full text Add to dashboard Cite

Germination is an effective process to improve the bioactivities including antioxidant and hypoglycemic activities of grains, but its effect on waxy wheat has not yet been actively studied. This study, therefore, examined the effect of germination time on the activities of Korean waxy and normal wheat sprouts. The total phenolic and flavonoid contents, and antioxidant activities of the waxy and normal wheat sprouts increased with germination time. Flavonoid content and antioxidant activity were higher in waxy wheat sprouts than in normal ones, but the total phenolic content and α-glucosidase inhibitory activity were not significantly different. The NO production ratio of MEF cells was higher for waxy wheat sprout than for normal ones, thereby indicating lower anti-inflammatory activity of waxy wheat sprouts. The viabilities of Caco-2 cells treated with waxy wheat sprouts was higher than that of cells treated with normal ones for the water extract. These results imply that waxy wheat sprouts exhibit better antioxidant activity and less cell toxicity for water extract, and therefore, could be used as a health-promoting food.

show abstract

“…Thus, it resulted that phenolic compounds are the main contributors to the antioxidant properties of N. baytopii. Similarly, several researchers have reported a strong correlation between antioxidant properties and the total amounts of phenolics [32,36,37]. Moreover, some authors have argued that the phenolic compounds in the members of the Nepeta genus were main players in the antioxidant assays [30,38,39].…”

Section: Resultsmentioning

confidence: 88%

“…These findings are presented in Table 4. Several studies have reported the relationship between high phenolic/flavonoid content and antioxidant activity [32][33][34]. The total antioxidant capacity of the extracts was assessed using the phosphomolybdenum method.…”

Section: Resultsmentioning

confidence: 99%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

Self Cite

View full text Add to dashboard Cite

Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.

show abstract

Chemical profiling, in vitro biological activities and Pearson correlation between phenolic contents and antioxidant activities of Caragana brachyantha Rech.f

Cited by 14 publications

References 34 publications

Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Antioxidant, α-Glucosidase Inhibitory, and Anti-Inflammatory Activities and Cell Toxicity of Waxy and Normal Wheat Sprouts at Various Germination Time

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Contact Info

Product

Resources

About