Chemical profiling of Aristolochia tagala Cham. leaf extracts by GC-MS analysis and evaluation of its antibacterial activity

Mariyammal, Veemarasu; Sathiageetha, V.; Amalraj, Singamoorthy; Gurav, Shailendra; Amiri‐Ardekani, Ehsan; Jeeva, Solomon; Ayyanar, Muniappan

doi:10.1016/j.jics.2022.100807

Cited by 24 publications

(8 citation statements)

References 33 publications

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“…Regarding flavonoids, concentrations exceeding 30 mg RE/g DT were detected in P. latifolia , D. incanum (Sw.), and A. odoratissima . These findings align with a study conducted by Mariyammal et al [ 12 ], which reported 3.2-fold lower phenolic content in the hydroalcoholic leaf extract of Aristolochia tagala compared to the species of the genus Aristolochia evaluated in this work (52.58 ± 0.06 mg GAE/g vs. 167.6 ± 1.3 mg GAE/g).…”

Section: Discussionsupporting

confidence: 93%

“…In San Basilio de Palenque, various connoisseurs have highlighted the usage of Aristolochia species in treating several diseases, including diabetes, cancer, inflammation, snakebites, viral and bacterial infections, and stomach problems, among others. These medicinal plants from the Aristolochia genus are not only utilized in America but also in Asian countries [ 12 ]. In Colombia, A. odoratissima is commonly known as ‘capitana’ [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Cytotoxicity of Nine Medicinal Plants from San Basilio de Palenque (Colombia) on HepG2 Cells

Caballero-Gallardo

Álvarez-Ortega

Olívero-Verbel

2023

Plants

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The utilization of plants with medicinal properties is deeply rooted in the traditional knowledge of diverse human populations. This study aims to investigate the cytotoxicity of nine plants commonly used by communities in San Basilio de Palenque, Bolivar (Colombia), for managing inflammation-related illnesses. Hydroethanolic extracts from various plant parts such as roots, stems, barks, or leaves were prepared through a process involving drying, powdering, and maceration in an ethanol–water (7:3) solution. The extracts were subsequently freeze-dried and dissolved in DMSO for the bioassays. Cytotoxicity against the human hepatoma HepG2 cell line was assessed using the MTT assay, with extract concentrations ranging from 0 to 500 µg/mL and treatment durations of 24 and 48 h. The total phenolic content of the nine extracts varied from 96.7 to 167.6 mg GAE/g DT. Among them, eight hydroethanolic extracts from Jatropha gossypiifolia L., Piper peltatum L., Malachra alceifolia, Verbesina turbacensis, Ricinus communis, Desmodium incanum, and Dolichandra unguis-cati showed low toxicity (IC50 > 500 µg/mL, 24 h) against HepG2 cells. On the other hand, the extracts of Aristolochia odoratissima L. (IC50 = 95.7 µg/mL) and Picramnia latifolia (IC50 = 128.9 µg/mL) demonstrated the highest cytotoxicity against the HepG2 cell line, displaying a modest selectivity index when compared to the HEKn cell line after 48 h of treatment. These findings suggest that medicinal plants from San Basilio de Palenque, particularly Picramnia latifolia and Aristolochia odoratissima, have potential activity against cancer cells, highlighting their potential for further research and development.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Nine Medicinal Plants from San Basilio de Palenque (Colombia) on HepG2 Cells

Caballero-Gallardo

Álvarez-Ortega

Olívero-Verbel

2023

Plants

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“…However, it has been reported that both tetrapentacontane and 1,54-dibromotetrapentacontane are found at a rate of 6.71% in the volatile oil of Citrus lemon species with evergreen leaves, while 1,54-dibromotetrapentacontane is found in the volatile oil of Alphitonia excelsa (Tithi, 2022). In addition, it has been reported that tetrapentacontane is 11.5% in Ephedra pachyclada volatile oil (Khanal et al, 2022), and 5.23% in Aristolochia tagala volatile oil (Mariyammal et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of monthly changes in essential oil yield and components of cherry laurel (Prunus laurocerasus L.) leaf

Akçura

2024

Grasas aceites

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This research was carried out to examine the monthly changes in both the volatile oil content and volatile components of cherry laurel leaves by taking samples every month for 12 months in Turkey. Harvest periods significantly affected volatile oil content (P < 0.01). Depending on harvest periods, volatile oil ratios ranged from 0.19 to 0.35%. The months of August, July, and September yielded the highest volatile oil ratios. Benzaldehyde, phenol, benzoic acid, benzeneacetonitrile, pentadecanone, 1,54-dibromotetrapentacontane and, tetrapentacontane were determined as components in the volatile oil. The ratio of benzaldehyde, the main active ingredient, varied between 83.89 and 94.41%, depending on the harvest time. The cherry laurel leaf should be harvested in July, August, and September for high essential oil ratios and in May, June, and July for high benzaldehyde ratios. Due to the high concentration of benzaldehyde in its volatile oil, cherry laurel evergreen leaf can be considered a valuable source of raw materials for the fragrance and pharmaceutical sectors.

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“…The term "phytochemicals" refers to a wide variety of biologically active natural compounds having pharmaceutical and nutritional attributes (Joselin et al, 2012;Sukumaran et al, 2014;Satya et al, 2017;Mariyammal et al, 2023). Phenolic compounds are a type of phytochemicals endowed with at least one hydroxylated benzene ring.…”

Section: Introductionmentioning

confidence: 99%

PRODUCTION AND CHARACTERIZATION OF GALLIC ACID WITH Streptomyces olivochromogenes ISOLATED FROM CASHEW NUT SHELL LIQUID (CNSL) DEPOSITED SOIL

Jacob¹

2022

Journal of Pharmaceutical Negative Results

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Phenolic compounds are a major type of phytochemicals and among them, phenolic acids are the most potent biologically active compounds. Cashew nutshell liquid (CNSL) is a by-product that serves as a rich source of phenolic acids. Gallic acid is a major category of phenolic acids and is notable for its antimicrobial, antiviral, and antifungal properties as well as for industrial applications. The global annual requirement of gallic acid is around 8000 tonnes. Currently, the industrial production of gallic acid is facilitated by acid hydrolysis of naturally derived gGallotannins. Since the present industrial process demands higher production costs along with low product yield and release of huge volumes of toxic effluents as by-products, an enzyme dependant eco-friendly production process for gallic acid is mandatory. Microorganisms can serve as substitutes for gallic acid production since they are endowed with the capability to degrade tannic acid by producing tannase. The bacteria Streptomyces olivochromogeneswas found to be capable of producing gallic acid in the present research. The gallic acid thus produced was found to possess effective antioxidant properties, thereby preventing protein denaturation in cells. The viability of the cancer cells was found to be significantly reduced. Reduction in oxidative stress along with upregulation of the apoptotic gene BAX coupled with the downregulation of the anti-apoptotic gene BCL2 is supposed to be the underlying mechanisms behind the anticancer activity of gallic acid. Our research manifests the therapeutic efficiency, especially the anticancer property, of gallic acid produced by Streptomyces olivochromogenes.

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Chemical profiling of Aristolochia tagala Cham. leaf extracts by GC-MS analysis and evaluation of its antibacterial activity

Cited by 24 publications

References 33 publications

Cytotoxicity of Nine Medicinal Plants from San Basilio de Palenque (Colombia) on HepG2 Cells

Cytotoxicity of Nine Medicinal Plants from San Basilio de Palenque (Colombia) on HepG2 Cells

Evaluation of monthly changes in essential oil yield and components of cherry laurel (Prunus laurocerasus L.) leaf

PRODUCTION AND CHARACTERIZATION OF GALLIC ACID WITH Streptomyces olivochromogenes ISOLATED FROM CASHEW NUT SHELL LIQUID (CNSL) DEPOSITED SOIL

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