Chemical reactions of calcium phosphate implants after implantationin vivo

Driessens, F. C. M.; Ramselaar, M. M. A.; Schaeken, H. G.; Stols, A.L.H.; Mullem, P.J. van; Wijn, J.R. de

doi:10.1007/bf00701237

Cited by 26 publications

(21 citation statements)

References 19 publications

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“…In relation to porosity and shape it is hypothesized that the observed transformation of Rh into an apatite as reported in the previous study [2] and confirmed by this study, will come about more rapidly with 0.5 0.7-mm sized, 20% microporous Rh particles than With 5 mm wide, 10% microporous, more solid, Rh cylinders. By this rapid transformation, bioresorbability of the original Rh particles may be strongly reduced.…”

Section: Discussionmentioning

confidence: 53%

“…The transformed Rh particles may be recognized by the host as a more familiar material, which may account for the significantly higher rate of bone deposition when compared to HA. As a difference in Ca/P ratio between the 3 and 6-month periods was not found, transformation of Rh must have come about within 3 months and according to the previous study [2] even within 6 weeks. A follow-up study using shorter experimental periods may give evidence to this hypothetical explanation and may reveal an even shorter period of transformation.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies on calcium phosphate resorption and transformation [1,2], divergent reactions to rhenanite (CaNaPO4) were observed when implanted in the forehead of domestic pigs (Sus scrofa) for periods of 6 weeks and 3 months. Most rhenanite (Rh) implants were surrounded by a wide soft tissue periimplant containing a large number of osteoclast-like cells strongly resorbing the implants.…”

Section: Introductionmentioning

confidence: 99%

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In vivo reactions to particulate rhenanite and particulate hydroxylapatite after implantation in tooth sockets

Ramselaar

Mullem

Kalk

et al. 1993

J Mater Sci: Mater Med

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To gain more information on the in vivo behaviour of rhenanite (CaNaP04), particles of this material and of hydroxylapatite were mixed with gelatin or saline and inserted in tooth sockets of beagle dogs for periods of 3 and 6 months. Rhenanite appeared to transform into an apatite containing carbonate, sodium and magnesium. Resorption of both calcium phosphate particles was not observed histologically and was not shown histomorphometrically. Calcium phosphates were not found in lymph node tissue. The presence of particles in the sockets gave rise to new bone formation. Histomorphometry demonstrated that statistically significant more bone deposition occurred on rhenanite particles than on hydroxylapatite particles. Also gelatin, meant as a spacer, contributed to new bone formation.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo reactions to particulate rhenanite and particulate hydroxylapatite after implantation in tooth sockets

Ramselaar

Mullem

Kalk

et al. 1993

J Mater Sci: Mater Med

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“…It will also be studied whether in the long run the cement is resorbed or transformed into another more bone-like mineral. The latter happened with rhenanite upon implantation [4]. A big advantage of the cements developed in this study is that they can be injected into the field of operation.…”

Section: Discussionmentioning

confidence: 99%

“…The biocompatibility of calcium phosphates has been well established I- [1][2][3][4]. Due to their good osteoconductivity calcium phosphate ceramics have been applied for bone replacements and augmentation.…”

Section: Introductionmentioning

confidence: 99%

Preparation and properties of some magnesium-containing calcium phosphate cements

Ginebra

Boltong

Driessens

et al. 1994

J Mater Sci: Mater Med

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Attempts were made to prepare magnesium-containing calcium phosphate cements. These were successful at the composition CaMg2(PO4)2xH20. X-ray diffraction showed that such a compound is not formed but that the cement consists of magnesium phosphate precipitated on the calcium phosphate admixture. The pH of this formulation is around 10 during setting and after. The cement is injectable. Its setting time is about 10 min. In this study compressive strength values were as high as 11 MPa and the diametral tensile strength was over 2MPa. Animal experiments must show whether it is suitable for replacement or augmentation of bone in non-load bearing situations.

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Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: Physicochemical characterization and assessment of rat bone marrow stromal cell viability

Oliveira

Silva

Malafaya

et al. 2008

J Biomedical Materials Res

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In this work, a new methodology is reported for developing hydroxyapatite (HA) scaffolds using an organic sacrifice template. The novelty of work consists of possibility of obtaining porous and highly interconnected scaffolds mimicking the sacrificial component. Our purpose consisted of evaluating the physicochemical properties of the HA scaffolds by means of Fourier transform infra-red spectroscopy, X-ray diffraction analysis, and scanning electron microscopy (SEM) attached with an X-ray detector. The HA scaffolds obtained possess a porosity of approximately 70%, and macropores diameter in the range of 50-600 microm. In contrast, results regarding the microcomputed tomography analysis have demonstrated both high pore uniformity and interconnectivity across the scaffolds. The compressive strength of the HA scaffolds was found to be 30.2 +/- 6.0 MPa. Bioactivity of the HA scaffolds was assessed by immersion into a simulated body fluid solution, in vitro. SEM observations have showed a deposition of apatite on the surface of the HA scaffolds, with a "cauliflower-like" morphology after 1 day, and tend to be more pronounced with the immersion time. The changes in calcium and phosphorus concentration were monitored by inductively-coupled plasma optical emission spectrometry. Cytotoxicity of the HA scaffolds was preliminarily investigated by carrying direct observation of mouse fibroblasts cells (L929 cell-line) death in the inverted microscope, and then cell viability was determined by means of carrying out a MTS assay. Complementarily, a luminescent cell viability assay based on the quantification of adenosine triphosphate was performed using rat bone marrow stromal cells (RBMSCs). A LIVE/DEAD assay and SEM analysis allowed the visualization of the RBMSCs adhesion and proliferation on the surface of the HA scaffolds. According to the results obtained from 3D architecture, mechanical properties, biocompatibility, and adhesion tests, it is suggested that HA scaffolds has potential to find applications in bone tissue engineering scaffolding.

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Chemical reactions of calcium phosphate implants after implantationin vivo

Cited by 26 publications

References 19 publications

In vivo reactions to particulate rhenanite and particulate hydroxylapatite after implantation in tooth sockets

In vivo reactions to particulate rhenanite and particulate hydroxylapatite after implantation in tooth sockets

Preparation and properties of some magnesium-containing calcium phosphate cements

Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: Physicochemical characterization and assessment of rat bone marrow stromal cell viability

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