Chemical regulation of mycotoxin biosynthesis

Chemical control of adaptive function of plant pathogenic fungi

“…As can be seen from the table, the sensitivity of the fungus Phoma glomerata to Folicur was significantly enhanced in the presence of acid 1 and analogue 3, which are inhibitors of toxigenesis [7]. The degree of fungal growth inhibition was equivalent to the effect caused by a manifold increase in the fungicide con centration.…”

“…fungus Aspergillius flavus [7]. The chemical com pounds used in this study were obtained as described earlier [6]; the concentration of the fungicide was cal culated with respect to the active compound.…”

“…In that capacity, com pounds I inhibited acetyl CoA dependent biosynthe sis of mycotoxins and melanins of the fungal cell wall and selectively inhibited the growth of pathogenic fungi [6]. Acids I exhibited a fundamentally different type of activity, which consisted in the ability to stim ulate the fungal metabolism (e.g., the biosynthesis of mycotoxins of different structure) [7]. Thus, acids I can serve as a tool for influencing the adaptive func tions of fungi (e.g., enhancing or attenuating the action of fungicides).…”

“…The effect of the test compounds on the sensitivity of fungi to Folicur was assessed by their combined effect on the fungal growth under the standard conditions used for study ing the fungicidal activity of such compounds [3,7]. The sum of individual activities of the same com pounds was taken as a control (Figs.…”

Determination of Aflatoxins in Groundnut and Groundnut products in Sudan using AflaTest® and HPLC

“…Mycotoxins are highly toxic and cause severe intoxications in human and animals, some of them are carcinogens, and the economic damage caused by mycotoxins reaches several billion of dollars every year (3).…”