Chemical Screening of Essential Oil Bearing Flora of Siberia IV. Composition of the Essential Oil of<i>Nepeta sibirica</i>L. Tops from Altai Region

Letchamo, W.; Korolyuk, Elena A.; Ткачев, А. В.

doi:10.1080/10412905.2005.9698973

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…qualitative composition of nepetalactone isomers, they represent interesting objects for investigating the biological activities of their extracts. As previously reported, N. rtanjensis contains much higher amounts of trans,cis-nepetalactone than cis,trans-nepetalactone [13,17], while N. sibirica possesses high amounts of cis,trans-nepetalactone [13,18]. N. nervosa contains nepetalactones only and in trace amounts [13,20].…”

Section: Introductionmentioning

confidence: 58%

“…The Nepeta species in this study included N. rtanjensis Diklić & Milojević, an endemic and critically endangered perennial in Serbia [17], N. sibirica L., which is endemic to central Asia, Mongolia and southern Siberia [18], and N. nervosa Royle ex Bentham, a plant species endemic to Kashmir [19]. To the best of our knowledge, these species have not previously been described for their antioxidant activities and zebrafish embryo toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Differences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents

Živković¹,

Živković²,

Šiler³

et al. 2018

ARCH BIOL SCI BELGRA

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Methanol extracts of three endemic Nepeta species were analyzed for their main secondary metabolites, terpenes and phenolics, and further investigated for antioxidant capacity and embryonic toxicity in zebrafish. UHPLC/DAD/(±) HESI-MS/MS analysis showed that the dominant compound in N. rtanjensis was trans,cis-nepetalactone, the cis,trans isomer of this monoterpene lactone was dominant in N. sibirica, while nepetalactone was detected only in traces in N. nervosa. In all investigated species, rosmarinic acid was the dominant phenolic compound, while other identified phenolic acids (chlorogenic, neochlorogenic and caffeic) were present in considerably lower amounts. ABTS and DPPH assays showed that the methanol extracts of N. rtanjensis, N. sibirica and especially N. nervosa possessed strong antioxidant activities, with the FRAP assay revealing high ferric-reducing abilities for all three tested species. Such a strong antioxidant potential, especially as manifested in the DPPH and FRAP assays, can be attributed to phenolic acids, and in the first place to rosmarinic acid. Increased lethality of zebrafish embryos in any of the treatments was not observed, but several toxic effects on embryonic development were recorded, such as pericardial and yolk sac edema. As in other Nepeta species, the three studied endemic species possessed a great potential for food conservation or as medicinal supplements if applied in optimized concentrations; however, alternative sources of plant material (e.g. field cultivation) should be established bearing in mind their vulnerability in nature.

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Section: Introductionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Differences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents

Živković¹,

Živković²,

Šiler³

et al. 2018

ARCH BIOL SCI BELGRA

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“…Among the constituents of the volatile oil, 4aα,7α,7aα-nepetalactone (87.1%), 4aα,7α,7aβ-nepetalactone (3.1%), β-caryophyllene (2.5%), and β-pinene (1.7%) were the major ones; the other constituents were present in relatively small amounts, representing only (3.6%) of the total oil. Nepetalactone isomers, which are the major constituens in our oil, were present in the essential oil of several Nepeta spp [11][12][13][14][15][16][17][18][19][20]. It was found that nepetalactones were responsible for the feline attractant properties of Nepeta species.…”

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confidence: 84%

Volatile constituents analysis of Nepeta cataria from central Iran

2009

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The genus Nepeta (Lamiaceae) comprises 250 species of perennial herbs that are distributed in Europe, Asia, North Africa, and the mountains of tropical Africa. These plants are commonly known as catmint [1]. The common Persian name of this genus is pune-sa, and about 67 species are recorded in Iran [2]. Many Nepeta species have some biological activity and are used in folk medicine because of their antispasmodic, diuretic, antiseptic, antitussive, antiasthmatic, and febrifuge activities [3][4][5][6][7][8]. Nepeta cataria L. (Lamiaceae) is one of the endemic species of this genus in Iran. N. cataria, commonly known as catnip, is native to Asia Minor and Southeast Europe and grows to a height of 90 cm. It is used as a fortifier, a disinfectant, and a cure against cold [1,9]. Literature surveys reveal that most oils of Nepeta species such as N. cataria contain nepetalactones as the main component. Antibacterial, fungicidal, and antiviral activities have been attributed to nepetalactones [3, 6, 10]. According to our finding, there is no report on the chemical composition of the essential oil of N. cataria growing in central Iran, so the aim of the present research was to determine the chemical composition of N. cataria essential oil. The constituents of the volatile oil were analyzed by gas chromatography (GC) and gas chromatography-mass spectroscopy (GC-MS). The components of the oil of air-dried herbal parts of N. cataria are listed Table 1, including percentages and retention indices of the components. Constituents are listed in order of their elution from an HP-5MS column. As is shown, nine compounds were identified in the oil of N. cataria, making up 98.0% of the total oil. Among the constituents of the volatile oil, 4aα,7α,7aα-nepetalactone (87.1%), 4aα,7α,7aβ-nepetalactone (3.1%), β-caryophyllene (2.5%), and β-pinene (1.7%) were the major ones; the other constituents were present in relatively small amounts, representing only (3.6%) of the total oil. Nepetalactone isomers, which are the major constituens in our oil, were present in the essential oil of several Nepeta spp [11][12][13][14][15][16][17][18][19][20]. It was found that nepetalactones were responsible for the feline attractant properties of Nepeta species. 4aα,7α,7aα-Nepetalactone, which was the main component of our oil, has been detected as the major one in four Nepeta species growing in Turkey [21] and also in N. cataria growing in Germany [22], while caryophyllene oxide, which was abundant in N. cataria from Lebanon [23] and Lithuania [24] (6.4%, 7.3% respectively), was not found in our work. β-Caryophyllene, which was the third major component of our oil, has been reported in the oil of some Nepeta species such as N. cataria [23], N. daenensis [25], and N. fissa from Iran [26], and in N. curviflora growing in Lebanon [23]. On the other hand, 1,8-cineole, which was the most abundant component in many Nepeta species [4, 27-30], was not present in our work. Also, linalool and germacrene D have been identified in sizable amounts in other Nepeta spec...

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“…However, the medicinal value of this genus is due to the presence of essential oils and flavonoids (Jamzad et al, 2003), which have potential roles in the treatment of human diseases. Some Nepeta species contain cyclopentanoid iridoid derivatives such as monoterpenes, sesquiterpenes, and nepetalactones (McElvain et al, 1941;Javidnia et al, 2005;Letchamo et al, 2005). N. grandiflora and N. clarkei produce essential oils that contain (S)-germacrene D compound (Birkett et al, 2010) and other compounds.…”

Section: Introductionmentioning

confidence: 99%

Selection of DNA barcoding loci for Nepeta deflersiana Schweinf. ex Hedge from chloroplast and nuclear DNA genomes

et al. 2014

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ABSTRACT. Molecular markers, mainly DNA-based are potential tools for DNA barcoding and phylogenetic study. The plant species belonging to the Nepeta genus have important medicinal value because of the presence of nepetalactones, and they have been used to treat human diseases. We amplified nuclear and chloroplast gene loci to develop a DNA barcode and phylogenetic study of Nepeta deflersiana. Among the studied loci, psbA-trnH and rps16 showed less identity within the genus than the other loci using the Basic Local Alignment Search Tool of the National Center for Biotechnology Information GenBank database. These loci can be used for the development of a DNA barcode to identify and preserve the identity of this species. We also constructed the phylogram of N. deflersiana and other Nepeta species retrieved from the GenBank database (nonredundant DNA-internal transcribed spacer). N. deflersiana was placed in the same clade as N. insaurica with a 99% bootstrap value.

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Chemical Screening of Essential Oil Bearing Flora of Siberia IV. Composition of the Essential Oil ofNepeta sibiricaL. Tops from Altai Region

Cited by 11 publications

References 10 publications

Differences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents

Differences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents

Volatile constituents analysis of Nepeta cataria from central Iran

Selection of DNA barcoding loci for Nepeta deflersiana Schweinf. ex Hedge from chloroplast and nuclear DNA genomes

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