Chemical sensing using a polymer coated long-period fiber grating interrogated by ring-down spectroscopy

Barnes, Jack A.; Brown, R. Stephen; Cheung, Adrienne H.; Dreher, Marian; Mackey, Gillian; Loock, Hans‐Peter

doi:10.1016/j.snb.2010.04.007

Cited by 50 publications

(22 citation statements)

References 23 publications

(28 reference statements)

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“…LPFG sensors have been reported to produce high-sensitivity resonant wavelength shift with the variation in refractive index (RI) of ambient medium, thereby offering label-free detection. Prominent citations on applications of LPFG-based biosensors include: antibody-antigen detection, 7 chemical sensing, 8 pH sensing, 9 glucose detection, 10 DNA, 11,12 bacterial detection, and other medical diagnostic applications. 13,14 Functionalizing the LPFG surface with molecular recognition elements such as enzymes, nucleic acids (DNA), antibodies, and antigens involves several bioreceptor immobilization methods which include covalent bonding, 15,16 ionic bonding, 17,18 absorption, 19 avidinbiotin interaction, and cross-linking through a multifunctional reagent.…”

Section: Introductionmentioning

confidence: 99%

Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection

Badmos

Sun

et al. 2017

J. Biomed. Opt

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, "Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection," J. Biomed. Opt. Abstract. Enzyme-functionalized dual-peak long-period fiber grating (LPFG) inscribed in 80-μm-cladding B/Ge codoped single-mode fiber is presented for sugar-level and specific glucose detection. Before enzyme functionalization, the dual-peak LPFG was employed for refractive index sensing and sugar-level detection and high sensitivities of ∼4298.20 nm∕RIU and 4.6696 nm∕% were obtained, respectively. Glucose detection probe was attained by surface functionalization of the dual-peak LPFG via covalent binding with aminopropyl triethoxysilane used as a binding site. Optical micrographs confirmed the presence of enzyme. The surface-functionalized dual-peak LPFG was tested with D-(+)-glucose solution of different concentrations. While the peak 2 at the longer wavelength was suitable only to measure lower glucose concentration (0.1 to 1.6 mg∕ml) recording a high sensitivity of 12.21 AE 0.19 nm∕ðmg∕mlÞ, the peak 1 at the shorter wavelength was able to measure a wider range of glucose concentrations (0.1 to 3.2 mg∕ml) exhibiting a maximum resonance wavelength shift of 7.12 AE 0.12 nm∕mg∕ml. The enzyme-functionalized dual-peak LPFG has the advantage of direct inscription of highly sensitive grating structures in thin-cladding fibre without etching, and most significantly, its sensitivity improvement of approximately one order of magnitude higher than previously reported LPFG and excessively tilted fibre grating (Ex-TFG) for glucose detection.

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Section: Introductionmentioning

confidence: 99%

Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection

Badmos

Sun

et al. 2017

J. Biomed. Opt

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“…So far, many interests have been focused on the biosensors based on the long period gratings (LPGs) [5] and their combination with photonic crystal fiber (PCF) [6] or microstructure optical fiber (MOF) [7], or based on the tapered fiber [8,9], micro/nano fiber [10] and microfiber Bragg grating [11]. With their surface functionalized by molecular recognition elements (i.e., antibodies, enzyme, etc.…”

Section: Introductionmentioning

confidence: 99%

Novel glucose sensor based on enzyme-immobilized 81° tilted fiber grating

Luo¹,

Yan²,

Sun³

et al. 2014

Opt. Express

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Abstract:We demonstrate a novel glucose sensor based on an optical fiber grating with an excessively tilted index fringe structure and its surface modified by glucose oxidase (GOD). The aminopropyltriethoxysilane (APTES) was utilized as binding site for the subsequent GOD immobilization. Confocal microscopy and fluorescence microscope were used to provide the assessment of the effectiveness in modifying the fiber surface. The resonance wavelength of the sensor exhibited red-shift after the binding of the APTES and GOD to the fiber surface and also in the glucose detection process. The red-shift of the resonance wavelength showed a good linear response to the glucose concentration with a sensitivity of 0.298nm·(mg/ml) −1 in the very low concentration range of 0.0~3.0mg/ml. Compared to the previously reported glucose sensor based on the GOD-immobilized long period grating (LPG), the 81° tilted fiber grating (81°-TFG) based sensor has shown a lower thermal cross-talk effect, better linearity and higher Q-factor in sensing response. In addition, its sensitivity for glucose concentration can be further improved by increasing the grating length and/or choosing a higher-order cladding mode for detection. Potentially, the proposed techniques based on 81°-TFG can be developed as sensitive, label free and micro-structural sensors for applications in food safety, disease diagnosis, clinical analysis and environmental monitoring.

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“…Besides, the use of expensive optical spectrum analyzer could be prevented and the measurement of ringdown time for many pulses would lead to a higher throughput. Within the past decade, FLRD has been rapidly developed and implemented in trace gas [12], refractive index [13], chemical [14] and pressure sensing [15].…”

Section: Introductionmentioning

confidence: 99%

Fiber loop ring-down refractive index sensor based on high-Q photonic crystal cavity

Zhao

Zhang

et al. 2012

2012 IEEE Sensors

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A miniature refractive index sensor formed by a high quality (Q-) photonic crystal (PhC) cavity based fiber loop ringdown (FLRD) was demonstrated. To the best of our knowledge, this technology has not been reported. The ring-down time would be changed with the transmittance of PhC cavity, which is related to the refractive index of the infiltrated liquids. By using the finite-difference time-domain (FDTD) method, the system sensitivity was simulated. Result showed that the sensitivity of this simple scheme could reach to 1.25ms per refractive index unit (RIU) and the detection limit below 8×10 -6 RIU was achieved. Moreover, the proposed structure has the potential to build onchip device for in-situ measurement with high sensitivity and high precision.

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Chemical sensing using a polymer coated long-period fiber grating interrogated by ring-down spectroscopy

Cited by 50 publications

References 23 publications

Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection

Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection

Novel glucose sensor based on enzyme-immobilized 81° tilted fiber grating

Fiber loop ring-down refractive index sensor based on high-Q photonic crystal cavity

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