Chemical, spectroscopic characterization and antibacterial activities in vitro of a novel gold(I)–ibuprofen complex

Fiori, Ana Thereza M.; Lustri, Wilton R.; Magalhães, Alviclér; Corbi, Pedro P.

doi:10.1016/j.inoche.2011.02.024

Cited by 22 publications

(13 citation statements)

References 17 publications

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“…27 Ibuprofen is currently one of the most popular nonsteroidal anti-inammatory drugs to treat fever, pain and inammation. Metal complexes of ibuprofen and its derivatives, including those of Cu(II), 28 Ru(II, III) 29 and Au(I) 30 were documented. While Cu(II) and Ru(II, III) complexes show a similar effect on carrageenan-induced edema in rats as the parent drug (ibuprofen), they show less gastric irritation and are more protective to ulceration than ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

“…29 The Au(I) complex shows positive antibacterial activity in vitro against Gramnegative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) microorganisms. 30 The octahedral coordination of Ir(III) cation might be completed with 2-phenylpyridine. In-depth studies have been reported on the use of Ir(III) complexes of 2-phenylpyridine as well as of polypyridine as anticancer 31 or imaging agents in live cells.…”

Section: Introductionmentioning

confidence: 99%

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Experimental and theoretical investigation of cyclometalated phenylpyridine iridium(iii) complex based on flavonol and ibuprofen ligands as potent antioxidant

2019

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical investigation of cyclometalated phenylpyridine iridium(iii) complex based on flavonol and ibuprofen ligands as potent antioxidant

2019

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“…A novel gold (I) complex with ibuprofen was synthesized and characterized by chemical and spectroscopic measurements (Fiori et al, 2011), that elemental analysis led to the composition of AuC 14 H 18 O 2 N. Infrared, 1 H and 13 C NMR data suggest that coordination of the ibuprofen ligand to Au(I) is carried out through the oxygen atom of the carboxylic group in a monodentate form. An antibiotic sensitive profile indicated the antibacterial activity in vitro of the complex against Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Structural, Conductometric and Antimicrobial Investigations of Ibuprofen Analgesic Drug Complexes with Certain Metal Ions

Naglah¹,

Al-Omar²,

El‐Megharbel³

et al. 2015

International J. of Pharmacology

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Metal complexes have been applied as medicinal agents in the treatment of different human infections and diseases. So, the aim of this study is focused on studying the spectroscopic, thermal and evaluating antimicrobial investigations of ibuprofen analgesic drug complexes formulas with Cu (II), Ni (II), Ag (I), Hg (II), UO 2 (II), Cd (II), Ba (II) and Al (III) metal ions. Complexes of Cu (II), Ni (II), Ag (I), Hg (II), UO 2 (II), Cd (II), Ba (II) and Al (III) with ibuprofen ligand as to evaluate the biological activity were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV-VIS, IR, 1 H-NMR spectroscopy and thermal analysis. The IR spectral data suggested that the ibuprofen ligand behaves as a monobasic bidentate ligand towards the central metal ion with deprotonated of carboxylic group. From the microanalytical data, the stoichiometry of the complexes 1:1, 1:2 and 1:3 (metal: ligand) was found. The metal complexes were screened for antibacterial activity against Gram-ve organisms as Escherichia coli and Pseudomonas aeruginosa, Gram +ve organisms as Bacillus subtilis and Bacillus cereus and antifungal organisms such as Aspergillus niger, Aspergillus flavus and Aspergillus oryzae. The resulted Ibu compounds has proved the thermal stability feature. The antimicrobial activities of the metal complexes of Ibu recorded a significant effect against some bacteria and fungi.

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“…Recently, Corbi et al utilized potassium dicyanoaurate(I) as gold sources to synthesize a series of Au(I) complex of antibacterial activity via the synthetic strategy of ligand exchange. They selected four different biological function molecules including MTZ (a precursor for a variety of biologically active molecules) [25], rimantadine (a pharmaceutical agent) [27], N-acetyl-L-cysteine (a natural sulfurcontaining amino acid) [28], ibuprofen (an antiinflammatory drug utilized as a cyclooxygenase inhibitor) [29] as the ligands of Au(I) coordination, separately. The synthetic protocols are simple and convenient.…”

Section: Antibacterial Study Of Au(i) Complexesmentioning

confidence: 99%

Recent Advances in Gold(I) Complexes Based Biological Applications

Shu¹,

Su²,

Zhou³

et al. 2015

Am. J. Biomed. Sci.

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The development of the synthesis of a wide range of Au(I) complexes reversibly promotes the advance in their practical usages, particularly, in biological applications. The formation of gold-sulfur rich protein adducts contributes to the cytotoxic nature of the gold compounds for chemotherapeutic approaches, while Au-Au interactions endow them with spectroscopic and luminescence properties. This article reviews that the recent five year progress for Au(I) complexes based biological applications, including the investigation of the development of new anticancer agents and antibacterial compounds, the application of biological imaging and the fabrication of novel sensors.

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Chemical, spectroscopic characterization and antibacterial activities in vitro of a novel gold(I)–ibuprofen complex

Cited by 22 publications

References 17 publications

Experimental and theoretical investigation of cyclometalated phenylpyridine iridium(iii) complex based on flavonol and ibuprofen ligands as potent antioxidant

Experimental and theoretical investigation of cyclometalated phenylpyridine iridium(iii) complex based on flavonol and ibuprofen ligands as potent antioxidant

Structural, Conductometric and Antimicrobial Investigations of Ibuprofen Analgesic Drug Complexes with Certain Metal Ions

Recent Advances in Gold(I) Complexes Based Biological Applications

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