Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine

Sucena, Suelen Ferreira; Paiva, Raphael Enoque Ferraz de; Abbehausen, Camilla; Mattos, Ives Bernardelli de; Lancellotti, Marcelo; Formiga, André Luiz Barboza; Corbi, Pedro P.

doi:10.1016/j.saa.2011.12.043

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…Recently, Corbi et al utilized potassium dicyanoaurate(I) as gold sources to synthesize a series of Au(I) complex of antibacterial activity via the synthetic strategy of ligand exchange. They selected four different biological function molecules including MTZ (a precursor for a variety of biologically active molecules) [25], rimantadine (a pharmaceutical agent) [27], N-acetyl-L-cysteine (a natural sulfurcontaining amino acid) [28], ibuprofen (an antiinflammatory drug utilized as a cyclooxygenase inhibitor) [29] as the ligands of Au(I) coordination, separately. The synthetic protocols are simple and convenient.…”

Section: Antibacterial Study Of Au(i) Complexesmentioning

confidence: 99%

Recent Advances in Gold(I) Complexes Based Biological Applications

Shu¹,

Su²,

Zhou³

et al. 2015

Am. J. Biomed. Sci.

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The development of the synthesis of a wide range of Au(I) complexes reversibly promotes the advance in their practical usages, particularly, in biological applications. The formation of gold-sulfur rich protein adducts contributes to the cytotoxic nature of the gold compounds for chemotherapeutic approaches, while Au-Au interactions endow them with spectroscopic and luminescence properties. This article reviews that the recent five year progress for Au(I) complexes based biological applications, including the investigation of the development of new anticancer agents and antibacterial compounds, the application of biological imaging and the fabrication of novel sensors.

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Section: Antibacterial Study Of Au(i) Complexesmentioning

confidence: 99%

Recent Advances in Gold(I) Complexes Based Biological Applications

Shu¹,

Su²,

Zhou³

et al. 2015

Am. J. Biomed. Sci.

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“…, the Ni-L5 and Ni-L 6 complexes undergo decomposition at a higher temperature than the rest of the complexes. This indicates that L 5 and L 6 ligands give the most stable complexes with Ni (II).…”

mentioning

confidence: 94%

“…But from the beginning of the development, the resistance of microorganisms to antimicrobial agents was recognized. In this regard, there is always a need for the identification of novel chemical compounds with antimicrobial activities [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant activity of the entire compounds using the DPPH method has also studied. (1-methylpyrrol-2-yl)phenyl)tetrazole (L 6 : Scheme1) were prepared following the general procedure [29], using a mixture of 0.5mmol of 5-(2-bromophenyl)-1-methyltetrazole, 1mmol of PivoK, 0.1mmol of PdCl(C 3 H 5 ) (dppb) in 2ml of DMA and 0.75mmol of 2-ethyl-4-methylthiazole for L 5 ligand and 2mmol of N-methylpyrrole for L 6 ligand. The reactions were performed at 150 o C under argon atmosphere, the coupling product obtained after evaporation of the solvent and purification on silica gel (Pentane-Et 2 O/ 70:30).…”

Section: Introductionmentioning

confidence: 99%

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Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Allab

Chikhi

Zaater

et al. 2020

Inorganica Chimica Acta

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Six new nickel (II) complexes with a series of tetrazole derivatives functionalized by different substituents {5-(2-(1-Benzyltetrazol-5-yl) phenyl)-2-ethyl-4-methylthiazole (L 1), 1-Benzyl-5-(2-(1methylpyrrol-2-yl)phenyl) tetrazole (L 2), 5-(2-(1-Pivalyltetrazol-5-yl)phenyl)-2-ethyl-4methylthiazole (L 3), 5-(2-(1-Methylpyrrol-2-yl) phenyl)-1-pivalyltetrazole (L 4), 2-Ethyl-4-methyl-5-(2-(1 methyltetrazol-5-yl) phenyl) thiazole (L 5) and 1-Methyl-5-(2-(1-methylpyrrol-2-yl)phenyl) tetrazole (L 6)} have been synthesized and characterized by analytical and spectral methods. The data clearly indicated that the nickel (II) complexes are coordinated to the monodentate tetrazole derivatives via nitrogen (N3) atom of the tetrazole ring. The octahedral geometry is observed for all the complexes. The thermogravimetric analysis revealed the presence of coordinated and hydrated water molecules in the coordination sphere. The DFT calculations performed on both the ligands and the complexes allowed to optimize the structures, the stability and to explain the electrochemical behavior and the biological activities of the nickel (II) complexes. The study of the substituents effects on the redox properties of the ligands and their nickel (II) complexes were discussed via cyclic voltammograms. Electron donating substituents shift the reduction potentials toward negative values, while anodic shift of the oxidation potentials is manifested by the substituents having an electron withdrawing effect. The in vitro antimicrobial activities of the ligands and their corresponding nickel (II) complexes have been evaluated against four bacterial and two fungal strains.

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“…The remarkable example of a silver-based drug is silver sulphadiazine that has been used topically as an antibacterial agent in the treatment of burns and wounds [16]. N-Heterocyclic carbenes (NHCs) are stable singlet carbenes that can act as excellent two electron donor ligands towards almost any element in the periodic table, and NHCs can bind to transition metals, and in practice, the complexes of silver and NHCs have been synthesized as novel potential anticancer agents [1,17,18].…”

Section: Introductionmentioning

confidence: 99%