Chemical Structure and Biological Activities of Secondary Metabolites from Salicornia europaea L.

Kim, Sojeong; Lee, Eun Young; Hillman, Prima F.; Ko, Jaeyoung; Yang, Inho; Nam, Sang Jip

doi:10.3390/molecules26082252

Cited by 36 publications

(34 citation statements)

References 159 publications

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“…Salicornia extracts represent a complex source of biomolecules with neuroprotective or antioxidant activities [ 10 ]. As expected by previous reports [ 26 , 27 , 28 , 29 , 30 ], we found many different compounds that can be responsible for the therapeutic effect of S-EE, mainly including caffeoylquinic acid derivatives, flavonoids, and fatty acids. Although the exact therapeutic mechanisms of S-EE were not revealed in this study, several phytochemicals present in the plant might have contributed to the protective effect in combination.…”

Section: Discussionsupporting

confidence: 89%

Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia

García-Rodríguez

Río

et al. 2022

Nutrients

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Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal halophyte that synthetizes high amounts of bioactive compounds, including polyphenols, in response to environmental stress. Aqueous, hydroalcoholic, and ethanolic extracts were prepared to investigate if dietary supplementation prior to ischemic challenge can prevent subsequent damage using two animal models. First, we screened the protective effect against hypoxia–reoxygenation in Drosophila melanogaster and observed that both ethanolic and hydroalcoholic extracts protected flies from the deleterious effects of hypoxia. Second, we confirmed the protective effect of S. ramosissima ethanolic extract against brain ischemia using the transient middle cerebral artery occlusion mice model. Four weeks of oral supplementation with the ethanolic extract before artery occlusion reduced infarct volume and lowered the plasma levels of the DNA peroxidant product 8-hydroxydeoxyguanosine. Phytochemical profiling of S. ramosissima ethanolic extract revealed 50 compounds. Thus, it represents a valuable source of bioactive compounds that show promising disease-modifying activities and could be further developed as an effective food supplement for the prevention or treatment of neurovascular disorders.

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Section: Discussionsupporting

confidence: 89%

Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia

García-Rodríguez

Río

et al. 2022

Nutrients

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Section: Halophyte Species For Current and Future Biomedical Applicationsmentioning

confidence: 99%

“…The bioactive compounds are listed in Table 1 and summarized in Section 2. The chemical structure and biological activities of secondary metabolites isolated from Salicornia europaea L. have recently been reviewed [15]. Over time, nature has been a rich source for various natural bioactive substances that have many applications in folk medicine and ethnopharmaceuticals [10][11][12].…”

Section: Halophyte Species For Current and Future Biomedical Applicationsmentioning

confidence: 99%

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

et al. 2021

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The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.

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“…Going deeper into the phytochemistry of Salicornia spp., some studies have also evidenced the presence of: (i) saponins (in S. europea and S. bigelovii); (ii) lipids, with a prevalence of palmitic acid (e.g., in S. ramosissima) or α-linolenic acid (e.g., in S. europea) [46]; (iii) steroid compounds, such as spinasterol and stigmasterol (in S. europea, S. herbacea, S. fruticosa, and S. bigelovii); (iv) alkaloid derivatives, saliherbine, and salicornin [47]; (v) flavonoids (mainly favanones and flavone derivatives) and phenolic acids in methanolic extracts from S. europea [47]. Due to the presence of sterols, triterpenoids saponins, and polyphenolic compounds, beneficial properties have been associated with Salicornia extracts, such as antioxidant, anti-inflammatory, immunomodulatory, hypolipidemic, and hypoglycemic effects [46][47][48][49][50].…”

Section: Purslanementioning

confidence: 99%

Neglected and Underutilized Plant Species (NUS) from the Apulia Region Worthy of Being Rescued and Re-Included in Daily Diet

et al. 2021

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Neglected and underutilized species (NUS) are cultivated, semi-domesticated, or wild plant species, not included in the group of the major staple crops, since, in most cases, they do not meet the global market requirements. As they often represent resilient species and valuable sources of vitamins, micronutrients, and other phytochemicals, a wider use of NUS would enhance sustainability of agro-systems and a choice of nutritious foods with a strategic role for addressing the nutritional security challenge across Europe. In this review, we focused on some examples of NUS from the Apulia Region (Southern Italy), either cultivated or spontaneously growing species, showing interesting adaptative, nutritional, and economical potential that can be exploited and properly enhanced in future programs.

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Chemical Structure and Biological Activities of Secondary Metabolites from Salicornia europaea L.

Cited by 36 publications

References 159 publications

Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia

Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Neglected and Underutilized Plant Species (NUS) from the Apulia Region Worthy of Being Rescued and Re-Included in Daily Diet

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