Chemical structure, anti-inflammatory and antinociceptive activities of a sulfated polysaccharide from Gracilaria intermedia algae

Costa, Luís Eduardo Castanheira; Brito, Tarcísio Vieira de; Damasceno, Renan Oliveira Silva; Sousa, Willer Malta de; Barros, Francisco Clark Nogueira; Sombra, Venícios Gonçalves; Júnior, José S C; Magalhães, Diva Aguiar; Souza, Marcellus H.; Medeiros, Jand‐Venes Rolim; Paula, Regina C.M. de; Barbosa, André Luiz R.; Freitas, Ana Lúcia Ponte

doi:10.1016/j.ijbiomac.2020.05.166

Cited by 29 publications

(16 citation statements)

References 68 publications

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“…Its strong immune activity is closely related to the connection way of glycoside bond, sulfate group and low molecular weight. It was reported that it reduced neutrophils migration, regulated the production of interleukin-1 β , reduced the peripheral mechanisms of traumatic pain, and slowed down the occurrence of inflammation ( Costa et al, 2020 ). These results suggested that GLP could be used as an effective immunoregulation in functional foods or dietary fiber supplementation.…”

Section: Physiological Activities Of Glpmentioning

confidence: 99%

Insights on preparation, structure and activities of Gracilaria lemaneiformis polysaccharide

Long

Liu

et al. 2021

Food Chemistry: X

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Section: Physiological Activities Of Glpmentioning

confidence: 99%

Insights on preparation, structure and activities of Gracilaria lemaneiformis polysaccharide

Long

Liu

et al. 2021

Food Chemistry: X

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“…Other biological activities such as anti-glycation [193], anti-inflammatory [194][195][196][197], anti-microbial [198,199], anti-coagulant [200][201][202][203][204], anti-ageing [205][206][207][208][209] and anti-obesity [208,209] have also been recognized in seaweed polysaccharides.…”

Section: Other Activitiesmentioning

confidence: 99%

Perspective on the Therapeutic Applications of Algal Polysaccharides

et al. 2021

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Algae are an enormous source of polysaccharides and have gained much interest in human flourishing as organic drugs. Algal polysaccharides have aroused interest in the health sector owing to the various bioactivities namely anticancer, antiviral, immunoregulation, antidiabetic and antioxidant effects. The research community has comprehensively described the importance of algal polysaccharides regarding their extraction, purification, and potential use in various sectors. However, regardless of all the intriguing properties and potency in the health sector, these algal polysaccharides deserve detailed investigation. Hence, the present review emphasizes extensively on the previous and latest developments in the extraction, purification, structural properties and therapeutic bioactivities of algal polysaccharides to upgrade the knowledge for further advancement in this area of research. Moreover, the review also addresses the challenges, prospective research gaps and future perspective. We believe this review can provide a boost to upgrade the traditional methods of algal polysaccharide production for the development of efficacious drugs that will promote human welfare.

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“…Nonetheless long term use of topical corticosteroids for chronic diseases like psoriasis may cause skin atrophy and even systemic adverse effects. 15 On the other hand, Gracilaria algae has anti-proliferative, anti-oxidative, anti-inflammatory (with decreasing of the cytokines and other immune mediators) and emollient effects, [7][8][9] suggesting it as a potential botanical alternative to topical steroids and with fewer side effects for treatment of the plaque-type psoriasis.…”

Section: Side Effectsmentioning

confidence: 99%

“…Insufficient response of the current topical medications along with associated side‐effects including skin irritation, dermatitis, atrophy and tachyphylaxis are presumed as therapeutic challenges of psoriasis 6 . Gracilaria algae is red macro algae which has demonstrated considerable reduction in cytokines concentration, anti‐inflammatory, anti‐cancer, anti‐radical and anti‐microbial activities in either mice models or cell cultures 7‐9 . According to our literature review, this is the first study evaluating the efficacy of Gracilaria alga in treatment of plaque type psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…6 Gracilaria algae is red macro algae which has demonstrated considerable reduction in cytokines concentration, anti-inflammatory, anti-cancer, anti-radical and anti-microbial activities in either mice models or cell cultures. [7][8][9] According to our literature review, this is the first study evaluating the efficacy of Gracilaria alga in treatment of plaque type psoriasis. Regarding the pathogenesis of psoriasis and aforementioned effects of Gracilaria algae, we proposed that this alga might be effective herbal medication, with possibly the least side effects, for treatment of the plaque type psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of Gracilaria algae 3% cream vs Clobetasol 0.05% cream in treatment of plaque type psoriasis: A randomized, split‐body, triple‐blinded clinical trial

Shatalebi

Jazi

Yegdaneh

et al. 2020

Dermatologic Therapy

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Gracilaria algae is red macro algae which has demonstrated considerable antiinflammatory effects. Our objective was to compare the efficacy of Gracilaria algae topical cream 3% vs Clobetasol cream 0.05% in treatment of plaque-type psoriasis. Thirty adult patients with baseline modified Psoriasis Area and Severity Index (PASI) score ≤12 were randomized to receive either Clobetasol or Gracilaria algae cream on right or left-sided symmetric plaques once daily for 8 weeks and follow-up of 4 weeks. Modified PASI score, patient's satisfaction using VAS and global physician assessment score were assessed to evaluate clinical response. Thirty patients with 94 symmetrical psoriasis plaques were enrolled in this trial. The mean baseline modified PASI score of both sides was similar; however, at the end of trial, modified PASI score was reduced more on the sides treated with Gracilaria algae cream (0.80 ± 0.19% vs 0.63 ± 0.25%, P < .05). No significant difference was found regarding mean physician global assessment score between the two groups (P > .05). Patients' satisfaction was significantly higher in favor of algae cream only at week 8 of the intervention (P < .05). Gracilaria algae cream can be an effective and safe alternative of Clobetasol in the treatment of plaque type psoriasis.

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Chemical structure, anti-inflammatory and antinociceptive activities of a sulfated polysaccharide from Gracilaria intermedia algae

Cited by 29 publications

References 68 publications

Insights on preparation, structure and activities of Gracilaria lemaneiformis polysaccharide

Insights on preparation, structure and activities of Gracilaria lemaneiformis polysaccharide

Perspective on the Therapeutic Applications of Algal Polysaccharides

Comparative evaluation of Gracilaria algae 3% cream vs Clobetasol 0.05% cream in treatment of plaque type psoriasis: A randomized, split‐body, triple‐blinded clinical trial

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