Chemical structure of methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

Zaharia, Cătălin; Zecheru, Teodora; Moreau, Marie; Pascaretti-Grizon, Florence; Mabilleau, Guillaume; Marculescu, Bogdan; Filmon, R.; Cincu, Corneliu; Staikos, Georgios; Chappard, Daniel

doi:10.1016/j.actbio.2008.06.009

Cited by 25 publications

(15 citation statements)

References 26 publications

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“…Variability in the diffusion and biodistribution of CRL-1666 may also paly a role in efficacy. Although there were no biopsies obtained in this study to determine paclitaxel levels in areas contiguous to the injection, biodistribution and pharmacokinetic determination of biodegradable copolymers as drug carriers for bone delivery have been extensively studied both in vivo and in vitro (8,10,18,20,31). Animal studies using breast tumor xenografts have demonstrated that intralesional administration of OncoGel has primary activity equal to or greater than the maximum tolerated systemic doses of intravenous or intraperitoneal paclitaxel, with controlled release of active drug within the tumor over a half-life of approximately 3 weeks (8).…”

Section: Adjuvant Oncogel For Experimental Spine Metastasismentioning

confidence: 99%

Adjuvant Treatment With Locally Delivered Oncogel Delays the Onset of Paresis After Surgical Resection of Experimental Spinal Column Metastasis

et al. 2009

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In a rat model of spinal metastatic disease, local delivery of OncoGel increased the efficacy of surgery and radiotherapy and delayed the onset of neurological decline. These results suggest that OncoGel may be an effective adjuvant therapy in the operative management of metastatic spinal column tumors and that combining local chemotherapy with surgery and adjuvant radiotherapy may improve outcomes of this disease.

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Section: Adjuvant Oncogel For Experimental Spine Metastasismentioning

confidence: 99%

Adjuvant Treatment With Locally Delivered Oncogel Delays the Onset of Paresis After Surgical Resection of Experimental Spinal Column Metastasis

et al. 2009

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“…Photoshop CS (Adobe Inc software) was used to determine the greyness of the films in the resulting image. The relative X-ray opacity of the films was then evaluated as the ratio of their greyness to that of aluminum (2 mm thickness), as reported in Zaharia et al, 5 Qu et al 17 and Erik et al 22 Cytocompatibility using in vitro culture Cytotoxicity evaluation of iodinated polyurethanes was done by the direct contact method with L929 mouse fibroblast cells based on ISO 10993-5 standard. 12 Test samples (iodinated polyurethanes), negative controls (high-density polyethylene), and positive controls (copper wire) in triplicate were placed on subconfluent monolayer of L929 mouse fibroblast cells.…”

Section: Evaluation Of Radiopacitymentioning

confidence: 99%

Intrinsically radiopaque polyurethanes with chain extender 4,4′-isopropylidenebis [2-(2,6-diiodophenoxy)ethanol] for biomedical applications

Dawlee

Jayabalan

2014

J Biomater Appl

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Radiopaque polyurethanes are used for medical applications as it allows post-operative assessment of the biomaterial devices using X-ray. Inherently, radiopaque polyurethanes based on polytetramethylene glycol (PTMG), polypropylene glycol, 4,4'-methylenebis(phenyl isocyanate), and a new iodinated chain extender 4,4'-isopropylidenebis[2-(2,6-diiodophenoxy)ethanol] with flexible spacers were synthesized and characterized. The iodinated polyurethanes were clear, optically transparent, and had high molecular weights. The polyurethanes also possessed excellent radiopacity and high thermal stability. The biocompatibility of the most promising iodinated polyurethane was evaluated both in vitro (cytotoxicity evaluation by direct contact and MTT assay, using L929 mouse fibroblast cells) and in vivo (toxicology studies in rabbits and subcutaneous implantation in rats). The material was nontoxic and well tolerated by the animals. Thus, these radiopaque and transparent polyurethanes are expected to have potential for various biomedical applications.

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“…4,[6][7][8][9] However, the major issue associated with these fibrous materials is the lack of high electron density elements and specific gravity in their inherent polymeric backbone, which leads to radiolucent under radiography techniques. 10,11 Thus, to visibly evaluate those fibrous materials after implantation in vivo is still remains a big challenge, which may result in a substantial risk during insertion and subsequent monitoring. 12 In research, it has been demonstrated that incorporating inorganic salts of heavy elements can sustainably increase the specific gravity, thereby improve radiopacity.…”

Section: Introductionmentioning

confidence: 99%

Iodinated poly(p-dioxanone) as a facile platform for X-ray imaging of resorbable implantable medical devices

Zhao

Xue

et al. 2020

J Biomater Appl

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Currently, implantable fibrous medical devices still suffer from invisibility under current clinical imaging techniques. To address this problem, 2, 3, 5-triiodobenzoic acid (TIBA) was recruited as a contrast agent, and then a set of iodinated poly( p-dioxanone) (PPDO) fibers was fabricated via melt-spinning hybrid blends of PPDO with TIBA (PPDO/TIBA). The impact of TIBA content on the rheological behavior of blends was evaluated firstly. The physical, chemical, and thermal properties of PPDO/TIBA fibers were investigated accordingly by SEM, FTIR, DSC, and TGA. Moreover, the radiopaque property of PPDO/TIBA hybrid fibers as a potential radio-opacifying platform for medical devices was verified in vitro and in vivo. Finally, the accumulated release results of the hybrid fibers during in vitro degradation indicate the continual X-ray visibility of the hybrid fibers maintains for 22 days. This intriguing iodinated platform may pave the way for constructing fibrous materials with in-situ X-ray tracking property.

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Chemical structure of methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

Cited by 25 publications

References 26 publications

Adjuvant Treatment With Locally Delivered Oncogel Delays the Onset of Paresis After Surgical Resection of Experimental Spinal Column Metastasis

Adjuvant Treatment With Locally Delivered Oncogel Delays the Onset of Paresis After Surgical Resection of Experimental Spinal Column Metastasis

Intrinsically radiopaque polyurethanes with chain extender 4,4′-isopropylidenebis [2-(2,6-diiodophenoxy)ethanol] for biomedical applications

Iodinated poly(p-dioxanone) as a facile platform for X-ray imaging of resorbable implantable medical devices

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