Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones

Zhao, Guang‐Chao; Gao, Wen; Zeng, Su-Ling; Li, Ping; Liu, E‐Hu

doi:10.1016/j.jff.2017.11.036

Cited by 150 publications

(119 citation statements)

References 89 publications

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“…The various reports suggested that PMFs had antioxidant effects and the systematic comparison of the biological effects of individual PMF in the identical experimental conditions illustrated the influence of the position and numbers of hydroxyl and methoxyl groups on their bioactivity [2]. On the contrary, antioxidant assays indicated that the major PMFs nobiletin and tangeretin showed an opposite tend in this study.…”

Section: Multivariate Analysis Of Main Components and Antioxidant Actsupporting

confidence: 37%

“…Citrus resources are the important fruit crops and/or herb materials and process many benefit functions due to the various biological ingredients. Citrus flavonoids were the major components derived from citrus fruits or other citrus parts and were composed of two main subgroups flavanones and polymethoxyflavones (PMFs) according to the previous reports [1,2]. The bioactive functions were abundantly investigated and were mainly attributed to their antioxidant capacities, which have been extensively applied in healthy and pharmaceutical products [3].…”

Section: Introductionmentioning

confidence: 99%

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Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Zhu

Zhou

et al. 2020

J of Separation Science

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The citrus herbs have proved their important medicinal and nutritional values as medicine–food dual‐purpose herbs, functional foods, or medical herbs in China. In this study, phytochemicals and antioxidant activity among ten typical citrus herbs (ethanol extracts) were investigated comprehensively. The major ingredients and their contents were analyzed by high‐resolution mass spectrometry, and the differences of typical fragment ions between flavanone‐7‐O‐rutinoside(s) and flavanone‐7‐O‐neohesperidoside(s) were discriminated properly in negative electrospray ionization mode. Total polyphenols, total flavonoids, 1,1‐diphenyl‐2‐picrylhydrazyl, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid), and ferric reducing antioxidant power tests were performed, which indicated their beneficial values and antioxidant effects. The medicine–food dual‐purpose herbs including Chenpi, Juluo, Daidaihua, Huajuhong, Xiangyuan, and Foshou exhibited antioxidant capacities significantly by decreasing intracellular reactive oxygen species intensity (P < 0.01), enhancing superoxide dismutase, catalase, and glutathione peroxidase activities (P < 0.01) in H2O2‐induced RIN‐m5F cells. Moreover, the functional foods Zhishi, Zhiqiao, and Qingpi showed moderate antioxidant bioactivity, while the medical herb Juhe showed weak antioxidant bioactivity, which were consistent with the multivariate analysis of their major flavonoids. The study provided a new sight for the chemical differentiation and practical application of citrus herbs as medicine–food dual‐purpose herbs, functional foods, or medical herbs.

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Section: Multivariate Analysis Of Main Components and Antioxidant Actsupporting

confidence: 37%

Section: Introductionmentioning

confidence: 99%

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Zhu

Zhou

et al. 2020

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…The phenolic hydroxyl groups attached to the ring structure of the flavonoids and are known to be antioxidants by scavenging free radicals, inhibiting lipid oxidation, or chelating metal ions [7]. Moreover, flavonoids affect the quality of fruits in terms of appearance, taste and nutritional value [8], and also effectively regulate many human diseases by mediating antioxidant, inflammatory, and subclasses: flavanones, flavone-glycosides, and polymethoxylated flavones (PMFs) [10]. The significant compound of citrus flavonoids fruits is presented, including hesperidin, nobiletin, naringin, and neohesperidin.…”

Section: Introductionmentioning

confidence: 99%

Profiling of Flavonoid and Antioxidant Activity of Fruit Tissues from 27 Chinese Local Citrus Cultivars

Chen

Wang

Tan

et al. 2020

Plants

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Flavonoid profile and antioxidant activity of citrus peels, pulps, and juices from 27 local citrus cultivars in China were investigated. Flavonoid composition and content were determined using UPLC-PDA. Total phenolic content (TPC) and total flavonoid content (TFC) were measured using a Folin–Ciocalteau reagent and Al(NO3)-NaNO2 complexometry, respectively. The antioxidant capacities of the extracts were evaluated by DPPH, ABTS and FRAP method, respectively. Citrus peel not only exhibited better antioxidant potential, but also presented more composition diversity and contained higher concentrations of flavonoids than pulp and juice. Different citrus species were characterized by their individual predominant flavonoids, contributing largely to the antioxidant activity, such as mandarin was characterized by hesperidin, nobiletin and tangeretin, while pummelo and papeda were characterized by naringin. The peel of Guihuadinanfeng (Citrus reticulata) had the highest TPC of 23.46 mg equivalent gallic acid/g DW (dry weight) and TFC of 21.37 mg equivalent rutin/g DW. Shiyueju (C. reticulata) peel showed the highest antioxidant capacity based on the antioxidant potency composite (APC) analysis. Overall, mandarin (C. reticulata) fruits peel contained more TPC and TFC, exhibiting higher antioxidant capacities than other species, and were good natural sources of flavonoids and antioxidants.

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“…3) indicate the possibility that nobiletin regulates dendritic cell function, resulting in augmentation of both humoral and cellular immune responses in vivo. Citrus polymethoxyflavones are flavones that bear two or more methoxy groups on their basic benzo-gpyron skeleton with a carbonyl group at the C-4 position (25). The number and positions of methoxy groups might influence the biological function of polymethoxyflavones.…”

Section: Resultsmentioning

confidence: 99%

Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

Nakamoto

Mitani

Urayama

et al. 2019

J Nutr Sci Vitaminol

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We examined the effect of nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice. Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production. In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl-Ficoll was not different in the control and nobiletin groups, suggesting that nobiletin does not directly stimulate antibody production. An in vitro study showed that treatment with nobiletin enhanced the ability of antigen presentation of bone marrow-derived dendritic cells. The in vivo and in vitro results indicate that nobiletin regulates immune function.

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Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones

Cited by 150 publications

References 89 publications

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Profiling of Flavonoid and Antioxidant Activity of Fruit Tissues from 27 Chinese Local Citrus Cultivars

Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

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