Chemical structures, extraction and analysis technologies, and bioactivities of edible fungal polysaccharides from Poria cocos: An updated review

Ng, Chester Yan Jie; Lai, Nicole Poh Yee; Ng, Wen Min; Siah, Kewin Tien Ho; Gan, Ren-You; Zhong, Linda L.D.

doi:10.1016/j.ijbiomac.2024.129555

Cited by 14 publications

(3 citation statements)

References 110 publications

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“…The chemical structure of polysaccharides is generally defined by their monosaccharide composition, configuration, position of glycosidic linkages, and other associated features. The structural properties of polysaccharides play a significant role in modulating their biological functions, which can be readily impacted under various extraction conditions [ 12 ]. The water extraction and alcohol precipitation method is an effective approach for the extraction and purification of target polysaccharides [ 13 ], utilizing the specific hydrogen bonding interactions between hydroxyl groups (-OH) in ethanol and in polysaccharide molecules, which would facilitate the aggregation and precipitation of polysaccharides [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Yu,

Long,

Chi

et al. 2024

Nutrients

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Ethanol fractional precipitation can initially separate polysaccharides according to the structure, which exhibits strong correlation with the biological activities. This study aimed to investigate the impact of varying ethanol concentrations on the structural characteristics, and the antitumor and antioxidant activities of polysaccharides derived from Dendrobium officinale through ethanol fractional precipitation, as well as their internal relationships. The polysaccharides acquired by absolute alcohol additions at a final liquor-ethanol volume ratio of 1:1, 1:2, and 1:4 were named DOP-1, DOP-2, and DOP-4, and the supernatant was named DOP-S. The results of the structural analysis revealed that the increase in ethanol concentrations resulted in a reduction in the molecular weights and the acetylation degree of the polysaccharides, as well as a decrease in mannose content and an increase in glucose content. In vitro experiments demonstrated that DOP-S exhibited optimal antitumor and antioxidant activities. Animal experiments further confirmed that DOP-S suppressed the growth of solid tumors significantly, enhanced lymphocytes, mediated immune ability, and improved the activity of antioxidant enzymes. These findings would establish a theoretical foundation and provide technical support for further advances and applications of polysaccharides derived from D. officinale in the fields of food and medicine.

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Section: Introductionmentioning

confidence: 99%

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Yu,

Long,

Chi

et al. 2024

Nutrients

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“…Wolfiporia extensa (WE), or Fu Ling, is an edible fungus with a long consumption history. It contains multiple bioactive components, including polysaccharides, triterpenoids, and steroids [ 17 , 18 , 19 , 20 , 21 ]. These components demonstrate pharmacological effects such as diuretic properties, immunomodulatory activity, anti-tumor activity, and hepatoprotection [ 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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“…Furthermore, as a medicinal food, TCM herbs can be easily included into one's diet. An example is Poria cocos being transformed into food products such as Poria cake, which has been proved to alleviate digestive disorders ( 5 ). Therefore, further research can be conducted to elucidate the main bioactive compounds in TCM medicinal foods and their interactions with the human body, and to conduct larger scale randomized controlled trials to validate their efficacy in post-COVID management.…”

mentioning

confidence: 99%

Editorial: Medical food therapy for post-COVID conditions: mechanism and clinical study

Ng,

Gan,

Wang

et al. 2024

Front. Nutr.

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Chemical structures, extraction and analysis technologies, and bioactivities of edible fungal polysaccharides from Poria cocos: An updated review

Cited by 14 publications

References 110 publications

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Editorial: Medical food therapy for post-COVID conditions: mechanism and clinical study

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