Chemical Structures of Lignans and Neolignans Isolated from Lauraceae

Li, Ya; Xie, Shuhan; Ying, Jin-Chuan; Wei, Wenjun; Gao, Kun

doi:10.3390/molecules23123164

Cited by 31 publications

(20 citation statements)

References 86 publications

(162 reference statements)

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“…Lignans are a type of secondary plant metabolite exhibiting diverse structures [ 9 ]. Plants derive a complex array of secondary metabolites from only a handful of relatively simple propenyl phenols [ 10 ]. Biosynthesis of lignans is characterized by a remarkable increase in molecular complexity [ 10 ].…”

Section: Biosynthesis Classification and Presence Of Lignans In Fmentioning

confidence: 99%

Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

et al. 2019

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Dietary guidelines universally advise adherence to plant-based diets. Plant-based foods confer considerable health benefits, partly attributable to their abundant micronutrient (e.g., polyphenol) content. Interest in polyphenols is largely focused on the contribution of their antioxidant activity to the prevention of various disorders, including cardiovascular disease and cancer. Polyphenols are classified into groups, such as stilbenes, flavonoids, phenolic acids, lignans and others. Lignans, which possess a steroid-like chemical structure and are defined as phytoestrogens, are of particular interest to researchers. Traditionally, health benefits attributed to lignans have included a lowered risk of heart disease, menopausal symptoms, osteoporosis and breast cancer. However, the intake of naturally lignan-rich foods varies with the type of diet. Consequently, based on the latest humans’ findings and gathered information on lignan-rich foods collected from Phenol Explorer database this review focuses on the potential health benefits attributable to the consumption of different diets containing naturally lignan-rich foods. Current evidence highlight the bioactive properties of lignans as human health-promoting molecules. Thus, dietary intake of lignan-rich foods could be a useful way to bolster the prevention of chronic illness, such as certain types of cancers and cardiovascular disease.

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Section: Biosynthesis Classification and Presence Of Lignans In Fmentioning

confidence: 99%

Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

et al. 2019

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“…As exclusion criteria, the following were used: (1) articles in languages apart from English, Portuguese, and Spanish, (2) review articles, (3) full text articles not found, (4) articles without one of the key words, (5) articles discussing a mixture of plants, and (6) articles that did not present the composition of the EOs.…”

Section: Search Strategymentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils in the Family Lauraceae: A Systematic Review of the Literature

et al. 2019

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The Lauraceae family is predominantly found in Asia and in the rainforests of the Americas, and consists mostly of aromatic trees. Being an essential oil producer, this family is used in the food, pharmaceutical, and cosmetic industries. This work presents a systematic review of the chemical composition and bioactivity of the essential oils from the Lauraceae family. Medline, Scielo, Web of Science, Lilacs, and Scopus were employed to identify articles published between 2000 and 2018, using “Lauraceae”, “essential oil”, and “biological activity” as key words. From 177 studies identified, 53 met the inclusion criteria. These studies indicated a predominance of the compounds β-caryophyllene and 1,8-cineole in Lauraceae species, and highlighted the antioxidant, antifungal, antibacterial, and anti-inflammatory activities. Essential oils extracted from this family thus have high potential for pharmacological applications.

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“…[3] Lignans are present in Ocotea duckei Vattimo-Gil (Lauraceae), popularly known as "Louro-de-cheiro", "Louro-pimenta" or "Louro-canela" and is widely distributed in the Northeast of Brazil, having in its leaves a furofuran lignan, called yangambin, which is the major constituent of the total fraction of lignoids of the species. [4][5][6] Yangambin has pharmacological effects; analgesic activity, [7] apoptosis induction in tumor cells, [8] anti-PAF, [9] anti-inflammatory, [10] vasorelaxant and hypotensive, [11] as well as leishmanicidal. [12,13] The therapeutic potential of medicinal plants is related to natural products, which are sources of several bioactive molecules and when isolated, their biological activities can be investigated through experimental models.…”

Section: Introductionmentioning

confidence: 99%

Embryotoxicity of Yangambin Isolated from Ocotea duckei Vattimo-Gil in Gallus gallus domesticus Embryos

Silva¹,

Castro²,

Lucena³

et al. 2021

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Introduction: Yangambin, a lignan predominant in the leaves of Ocotea duckei Vattimo-Gil, has several biological activities, such as anti-convulsant, analgesic, anti-inflammatory and leishmanicidal. Objectives: The aim of this study was to evaluate the embryotoxicity of yangambin on the neurodevelopment of Gallus gallus domesticus embryos. Materials and Methods: 120 fertilized eggs were divided in three groups: G1 (PBS with 0.1 % Tween 80), G2 (50 µg/ml yangambin) and G3 (65 µg/ml yangambin) and each egg was inoculated with 100 µL of the respective solutions. The fertilized eggs were incubated at a temperature of 37.5°C, with a relative humidity of 65% to 75%, for 48 hr and then their embryos were histologically processed. Results: In staging, carried out according to Hamburger and Hamilton (1951), variations of stages were identified. In all groups, the morphological analysis revealed the closure of the anterior neuropore and absence of malformations in the optic vesicles and in the secondary encephalic vesicles. In the caudal region, a standard development of the neural tube was observed, with well-segmented somites and regression of the primitive line. The cross sections showed that the internal structure of the somite's, composed of dermatome, myotome and sclerotome, was preserved. The statistical analysis did not show significant differences between the groups regarding the morphometry of the cephalic and caudal regions of the neural tube. Conclusion: Yangambin did not show embryotoxic effects on the neurodevelopment of Gallus gallus domesticus embryos, under the tested conditions.

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Chemical Structures of Lignans and Neolignans Isolated from Lauraceae

Abstract: Lauraceae is a good source of lignans and neolignans, which are the most chemotaxonomic characteristics of many species of the family. This review describes 270 naturally occurring lignans and neolignans isolated from Lauraceae.

Cited by 31 publications

References 86 publications

Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

Chemical Composition and Biological Activities of Essential Oils in the Family Lauraceae: A Systematic Review of the Literature

Embryotoxicity of Yangambin Isolated from Ocotea duckei Vattimo-Gil in Gallus gallus domesticus Embryos

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