Chemical Studies of the Primer Mouse Pheromones

Novotný, Miloš V.; Jorgenson, James W.; Carmack, Marvin; Wilson, Shawn; Boyse, Edward A.; Yamazaki, Kunio; Wilson, Melba C.; Beamer, Wesley G.; Whitten, W. K.

doi:10.1007/978-1-4684-1027-3_23

Cited by 33 publications

(17 citation statements)

References 25 publications

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“…Castration did not change dehydro-exo-brevicomin levels in M. spicilegus significantly in contrast to the suppressed levels of dehydro-exo-brevicomin in the samples from castrated M. domesticus (Novotny et al, 1980;Harvey et al, 1989). Trace levels of the dominant male mouse pheromone for M. domesticus, -farnesene (Harvey et al, 1989), were detected in the intact male M. spicilegus urine, but were not seen in female or castrated animals.…”

Section: Resultsmentioning

confidence: 62%

Comparison of Urinary Scents of Two Related Mouse Species, Mus spicilegus and Mus domesticus

Soini

Wiesler²,

Koyama³

et al. 2009

J Chem Ecol

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Section: Resultsmentioning

confidence: 62%

Comparison of Urinary Scents of Two Related Mouse Species, Mus spicilegus and Mus domesticus

Soini

Wiesler²,

Koyama³

et al. 2009

J Chem Ecol

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“…The first analytical report of urinary volatile compounds from mice with different MHC types was published by Novotny et al (1980). They compared the volatile profiles of male inbred mouse strains AKR-H2 b , AKR-H2 k and C57BL/6-H2 k (B6-H2 k ).…”

Section: Chemical Investigations Of Mhc Odourtype In Micementioning

confidence: 99%

“…For example, 2-sec-butyl-4,5-dihydrothiazole in urine is influenced by MHC type and mouse strain (Novotny et al 1980;Willse et al 2006;Röck et al 2007;Zhang et al 2007). The amount of this pheromone in urine is also regulated by gender (Liebich et al 1977) and age (Osada et al 2008).…”

Section: Mhc Odourtypes and Complexity Of Individual Odour Signaturesmentioning

confidence: 99%

“…The amount of this pheromone in urine is also regulated by gender (Liebich et al 1977) and age (Osada et al 2008). The level of another pheromone in urine, 3,4-dehydro-exo-brevicomin, is also affected by background strain, diet and age (Novotny et al 1980;Willse et al 2006;Zhang et al 2007;Kwak et al 2008;Osada et al 2008). Finally, we detected methylthiomethanethiol in the urines collected from the BALB mice (BALB/b, BALB/k and BALB/bk) but not in those from the B6 mice (B6, B6-H2 k and B6-H2 bk ) used for the studies conducted by Willse et al (2006), and its concentration was significantly higher in the MHC heterozygote (H2 bk ) of the BALB mice than in the homozygotes (H2 b and H2 k ; J.…”

Section: Mhc Odourtypes and Complexity Of Individual Odour Signaturesmentioning

confidence: 99%

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In search of the chemical basis for MHC odourtypes

et al. 2010

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Mice can discriminate between chemosignals of individuals based solely on genetic differences confined to the major histocompatibility complex (MHC). Two different sets of compounds have been suggested: volatile compounds and non-volatile peptides. Here, we focus on volatiles and review a number of publications that have identified MHC-regulated compounds in inbred laboratory mice. Surprisingly, there is little agreement among different studies as to the identity of these compounds. One recent approach to specifying MHC-regulated compounds is to study volatile urinary profiles in mouse strains with varying MHC types, genetic backgrounds and different diets. An unexpected finding from these studies is that the concentrations of numerous compounds are influenced by interactions among these variables. As a result, only a few compounds can be identified that are consistently regulated by MHC variation alone. Nevertheless, since trained animals are readily able to discriminate the MHC differences, it is apparent that chemical studies are somehow missing important information underlying mouse recognition of MHC odourtypes. To make progress in this area, we propose a focus on the search for behaviourally relevant odourants rather than a random search for volatiles that are regulated by MHC variation. Furthermore, there is a need to consider a 'combinatorial odour recognition' code whereby patterns of volatile metabolites (the basis for odours) specify MHC odourtypes.

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“…Although the reason is unclear, one possible explanation is that only volatile molecules could pass through the mesh of the mask and therefore the stimulation might have been insufficient as compared with the single application where the goat was allowed to not only smell but also taste the male goat hair. Mammalian pheromones were suggested to exhibit their effects more strongly if plural molecules could act cooperatively rather than as a single molecule [23][24][25][26]. Pheromones which induce the male effect in sheep, for example, are speculated to be a combination of two or more substances [27].…”

Section: Discussionmentioning

confidence: 99%

Stimulation of the GnRH Pulse Generator Activity by Continuous Exposure to the Male Pheromones in the Female Goat.

Ichimaru

Takeuchi

Mori

1999

Journal of Reproduction and Development

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Abstract. Male pheromones in ruminant species such as sheep and goats are known to reactivate quiescent ovarian function in seasonally anestrous females. We have previously shown that only a few minutes exposure to the male pheromone can accelerate the GnRH pulse generator activity immediately in the female goat. In this study the effect of 4 h continuous exposure to the male pheromone on the GnRH pulse generator activity was examined by recording the specific multiple unit acitivity (MUA) from the medial basal hypothalamus. Pooled buck hair was used as the source of male pheromone. Six ovariectomized estradiol-primed does were fitted with a nose-mask for 8 h, and during the latter 4 h period 2.0 g of pooled male hair was set in the chamber at the rostral end of the mask. As compared with the period when only an empty mask was put on, the exposure to the male hair resulted in a shortening (p<0.05) of the interval between the MUA volleys, namely the electrophysiological manifestation of the pulsatile GnRH neurosecretion. This stimulatory effect was observed throughout the time when animals were exposed to the male pheromone. This result demonstrates that the hypothalamic GnRH pulse generator of the recipient female is accelerated as long as the exposure to the male pheromone continues.

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Chemical Studies of the Primer Mouse Pheromones

Cited by 33 publications

References 25 publications

Comparison of Urinary Scents of Two Related Mouse Species, Mus spicilegus and Mus domesticus

Comparison of Urinary Scents of Two Related Mouse Species, Mus spicilegus and Mus domesticus

In search of the chemical basis for MHC odourtypes

Stimulation of the GnRH Pulse Generator Activity by Continuous Exposure to the Male Pheromones in the Female Goat.

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