Chemical studies on tobacco smoke.  Quantitative analysis of hydrazine in tobacco and cigarette smoke

Liu, Yu-Ying.; Schmeltz, I.; Hoffmann, Dietrich

doi:10.1021/ac60343a046

Cited by 164 publications

(77 citation statements)

References 7 publications

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“…Dimethylhydrazine has been shown to be present in tobacco [12], commercial and wild mushrooms [13] and other food items also [14].…”

Section: Introductionmentioning

confidence: 99%

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

Sharma

2011

Ind J Clin Biochem

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The present study was carried out to investigate the protective role of Triphala (a combination in equal proportions by weight of fruit powder of Terminalia belerica, Terminalia chebula and Emblica officinalis) against 1,2-dimethylhydrazinedihydrochloride (DMH) induced Endoplasmic reticulum stress (ER stress) in mouse liver. An oral dose of 3 mg/kg body wt in drinking water for 5 weeks significantly (P \ 0.001) increased the levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum Alkaline phosphatase (ALP) and total bilirubin thus suggesting damage to mouse liver and biliary dysfunction. The DMH administration invariably led to increase in the liver microsomal proteins of molecular weight of about 29 (ERp29) and 53 kDa (ERp53) and decrease in the protein of molecular weight of 36 kDa (ERp36) thereby suggesting the interference of DMH and its metabolites with normal protein biosynthesis and folding, in the reticular membranes of the liver cells thus developing ER stress. Histological studies show necrosis, large sized hepatocytes with increased N:C ratio, aberrant mitotic figures and prominent nucleoli in the liver of DMH treated mice. In animals fed 5% Triphala in diet (w/w) during DMH administration, there was significant decrease in the above changes in the liver suggesting the suppression of DMH induced ER stress in liver. Triphala significantly (P \ 0.05) decreased lipid peroxidation and also the activity of lactate dehydrogenase (LDH) in mouse liver. It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.

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“…Dimethylhydrazine has been shown to be present in tobacco [12], commercial and wild mushrooms [13] and other food items also [14].…”

Section: Introductionmentioning

confidence: 99%

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

Sharma

2011

Ind J Clin Biochem

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“…Humans may be exposed to hydrazines in their environment. This chemical occurs as industrial and food contaminants (Toth et al, 1975) and is also found in tobacco (Liu et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model

Davis

Patterson²,

Crouch³

1992

Br J Cancer

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An increased incidence of colonic cancer is associated with chronic inflammatory bowel disease. Sulphasalazine, metronidazole and more recently, modified forms of 5-aminosalicylic acid are used for maintenance therapy of inflammatory bowel disease. In a series of experiments, we used the 1,2-dimethylhydrazine animal model of colonic cancer in conjunction with these drugs, to study the effect on the development of colon cancer. Inbred male Wistar rats were divided into groups receiving orally: metronidazole 18 mg Kg-1 dy-1; sulphasalazine 60 mg Kg-1 dy-1; 5-aminosalicylic acid 30 and 60 mg Kg-1 dy-1 and olsalazine 60 mg Kg-1 dy-1 administered daily. Half of each group also received weekly injections of DMH 40 mg Kg-1. Metronidazole, sulphasalazine and 30 mg Kg-1 dy-1 5-aminosalicylic acid were co-carcinogenic, increasing either the number of cancers or tumour size. In contrast 60 mg Kg-1 dy-1 5-aminosalicylic acid inhibited tumour size and olsalazine had no effect. These results may have a bearing on long term maintenance therapy in inflammatory bowel disease. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6

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“…2 Quantifying the hydrazine produced leads to a better understanding of the Anammox reaction. Hydrazine content is conventionally determined by voltammetry, 3 coulometry, 4 gas chromatography, 5 fluorescence spectroscopy, 6 spectrophotometry, 7,8 and titration. 9 Quantification of low concentrations of hydrazine in a water sample is usually done by spectrophotometry, with a typical assay using p-dimethylaminobenzaldehyde (p-DMAB) colorimetry.…”

Section: Introductionmentioning

confidence: 99%

Determination of Trace Hydrazine in Environmental Water Samples by in situ Solid Phase Extraction

et al. 2017

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Chemical studies on tobacco smoke. Quantitative analysis of hydrazine in tobacco and cigarette smoke

Cited by 164 publications

References 7 publications

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model

Determination of Trace Hydrazine in Environmental Water Samples by in situ Solid Phase Extraction

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