Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract

Escher, Graziela Bragueto; Santos, Jânio Sousa; Rosso, Neiva Deliberali; Marques, Mariza Boscacci; Azevedo, Luciana; Carmo, Mariana Araújo Vieira do; Daguer, Heitor; Molognoni, Luciano; Prado-Silva, Leonardo do; Sant’Ana, Anderson S.; Silva, Márcia Cristina; Granato, Daniel

doi:10.1016/j.fct.2018.05.046

Cited by 75 publications

(40 citation statements)

References 65 publications

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“…Treatment with UE extracts, in concentrations between 0.02 and 0.32 µg GAE/mL, has not induce any significant decrease in cells viability compared to non-treated cells, as shown in Figure 4. Our results appear to be well supported by previous investigations that report a hardly any or no cytotoxicity and antiproliferative effect of Centaurea extracts at low dose against human cell lines, e.g., NALM-6, REH, NB4, KMM-1 [42], HepG2 [43], Caco-2 [44], and A549 [19].…”

Section: In Vitro Bioactive Antioxidant Assayssupporting

confidence: 92%

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Screening of Antioxidant Potentials and Bioactive Properties of the Extracts Obtained from Two Centaurea L. Species (C. kroumirensis Coss. and C. sicula L. subsp sicula)

et al. 2020

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Herbal medicines, dietary supplements, or infusions with health promoting effects can note strong consumer demand. Hence, researchers and scientists have been increasingly focusing on the promotion of medicinal plants. In this respect, the present study has the evaluation of the biological properties of different extracts (hexane, chloroform, methanol, ultrasonic, essential oil, and supercritical) obtained from two Centaurea species (C. kroumirensis (Coss.) and C. sicula L. subsp sicula) as purpose. Antioxidative activities were assessed by in vitro assays including total phenolic content, free radical scavenging assay and ferric ion reducing power. Among the fourteen extracts examined, the highest total phenolic content (TPC) and antioxidant abilities were recorded in ultrasonic ethanol extracts of both Centaurea species. Additionally, these extracts exhibited a noticeable strong protective effect of the human skin fibroblast cell line (HS-68) that was exposed to oxidative stress induced by hydrogen peroxide. According to our results, the sonication with ethanol might be an ideal, rapid, and eco-friendly extraction method for obtaining a polyphenol-rich extract that exhibited high antioxidant activity. The results presented herein suggest that Centaurea species could be promoted as an antioxidant resource that could be exploited for the development of nutraceuticals or in pharmacology industry.

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Section: In Vitro Bioactive Antioxidant Assayssupporting

confidence: 92%

“…There is still growing worldwide interest in the antioxidant ability of phenolics of this genus. Several studies have reported that many Centaurea species, such as C. cyanus L [19], C. bornmuelleri Hausskn [20], C. drabifolia subsp. drabifolia and C. lycopifolia [21], C. amaena Boiss.…”

Section: Introductionmentioning

confidence: 99%

Screening of Antioxidant Potentials and Bioactive Properties of the Extracts Obtained from Two Centaurea L. Species (C. kroumirensis Coss. and C. sicula L. subsp sicula)

et al. 2020

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“…Then, both samples were lyophilized (Free Zone 4.5, Labconco, Kansas City, MO, USA), reduced to fine powder (20 mesh), and kept at -20°C until analysis. It should be noted that some authors refer to flowers as being petals (Escher et al, 2018;Pires et al, 2018Pires et al, , 2017. This misunderstanding is due to the fact that the tubular flowers in the central part of the capitulum structure of this Asteraceae plant resemble single petals.…”

Section: Plant Samplesmentioning

confidence: 99%

“…A good summary about the historical development in research about the blue flower colour is presented by Yoshida et al (2009). Reports regarding the evaluation of the bioactive potential of flower or capitulum extracts also exist from different authors (Escher et al, 2018;Garbacki et al, 1999;Marian et al, 2017;Pires et al, 2018). However, as far as we know, no studies describing the bioactive potential of the non-edible receptacle and involucre separately from the flowers exist in the literature.…”

Section: Introductionmentioning

confidence: 99%

Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part

Lockowandt

Pinela

Roriz

et al. 2019

Industrial Crops and Products

156

114

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Cornflower is a flowering weed and ornamental plant whose blue flowers have been used for food, decorative and colouring purposes. In this study, the upper (edible flowers) and lower (non-edible receptacle and involucre) parts of the capitulum were studied and compared for their chemical composition and bioactive properties. The flowers were richer in tocopherols, organic acids, and apigenin derivatives (mainly apigenin-7-O-glucuronide-4′-O-(6-O-malonylglucoside)) than the non-edible bristly part (where syringic acid predominated). Four cyanidin derivatives were identified in the flowers. The extract of the non-edible part was more efficient in inhibiting the formation of thiobarbituric acid reactive substances (TBARS), the bleaching of β-carotene, and the haemolysis of the erythrocytes membrane. In general, the extracts were more active against Gram-positive bacteria and had no cytotoxicity against non-tumour liver PLP2 cells. Therefore, while flowers are a potential source of natural cyanidin-based colorants, the lower part of the capitulum has bioactive properties to be exploited in different food or pharmaceutical formulations.

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“…Until now, these studies were mainly concentrated in grape, red wine, and beverages at pH 3 to 4 (Chung, Rojanasasithara, Mutilangi, & Mcclements, ; Gonçalves, Wessel, Cardoso, Rocha, & Coimbra, ; Rodrigues, Ricardo‐Da‐Silvaa, & Laureano, ), whereas studies at weakly acidic pH and neutral pH were fewer. Anthocyanins are thermally stable below pH 3 while unstable at neutral pH (Escher et al., ; Tachibana et al., ). Hence, enhancing stability of anthocyanins at weakly acidic and neutral conditions will be good for their applications in food systems.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Protein Isolate with Anthocyanin Extracted from Black Soybean and Its Effect on the Anthocyanin Stability

Wang

Xie

2019

Journal of Food Science

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The interactions between black soybean protein isolate (B‐SPI) and cyanidin 3‐O‐glucoside (C3G), anthocyanin extracted from black soybean coat was investigated under neutral conditions. The fluorescence spectra showed that C3G had fluorescence quenching effects on B‐SPI. Thermodynamic parameters showed that ∆G < 0, which demonstrated that the binding was a spontaneous reaction. Since ΔH > 0 and ΔS > 0, the interactions between C3G and B‐SPI was mainly hydrophobic interactions. Fourier infrared spectroscopy results suggested that the contents of α‐helix and β‐sheet structure showed an increasing trend, whereas the β‐angle content displayed a decreasing trend. The degradation of C3G followed first‐order kinetics at 85 °C and 100 °C. After the interactions with B‐SPI, the degradation rate constant was decreased and the half‐life of C3G was prolonged from 70.25 ± 0.90 min to 175.64 ± 38.04 min at 85 °C, from 62.68 ± 1.1 min to 72.51 ± 2.5 min at 100 °C (p < 0.05). The results indicated that the interactions of B‐SPI and C3G improved the thermal stability of C3G under heating conditions.

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Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract

Cited by 75 publications

References 65 publications

Screening of Antioxidant Potentials and Bioactive Properties of the Extracts Obtained from Two Centaurea L. Species (C. kroumirensis Coss. and C. sicula L. subsp sicula)

Screening of Antioxidant Potentials and Bioactive Properties of the Extracts Obtained from Two Centaurea L. Species (C. kroumirensis Coss. and C. sicula L. subsp sicula)

Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part

Interaction of Protein Isolate with Anthocyanin Extracted from Black Soybean and Its Effect on the Anthocyanin Stability

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