Chemical Surface Modification of Polymeric Biomaterials for Biomedical Applications

Sun, Wenjuan; Liu, Wenying; Wu, Zhaoqiang; Chen, Hong

doi:10.1002/marc.201900430

Cited by 123 publications

(59 citation statements)

References 368 publications

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“…The unregulated attachment of microbes on implant materials surface is an undesirable phenomenon that causes infection and degradation of the function of medical instruments [ 5 , 6 ]. In medical devices antifouling materials are originated by intermolecular interaction between extracellular biomolecules and the designed surfaces [ 7 , 8 , 9 ]. Most commonly used antimicrobial reagents for bio medical applications can be classified into four specific categories that include organic agents such as formaldehyde and isothiazolones, oxidants that include chlorine and peroxides, electrophilic agents such as mercury, copper and silver, cationic active compounds such as quaternary ammonium and chlorhexidine [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications

et al. 2021

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Amphiphilic copolymers are recognized as important biomaterials and used as antibacterial agents due to their effective inhibition of bacterial growth. In current study, the amphiphilic copolymers of P(DMAEMA-co-MMA) were synthesized using free radical polymerization by varying the concentrations of hydrophilic monomer 2-dimethylamino ethylmethacrylate (DMAEMA) and hydrophobic monomer methyl methacrylate (MMA) having PDI value of 1.65–1.93. The DMAEMA monomer, through ternary amine with antibacterial property optimized copolymers, P(DMAEMA-co-MMA), compositions to control biofilm adhesion. Antibacterial activity of synthesized copolymers was elucidated against Gram-positive Staphylococcus aureus (ATCC 6538) and Gram-negative Escherchia coli (ATCC 8739) by disk diffusion method, and zones of inhibition were measured. The desired composition that was PDM1 copolymer had shown good zones of inhibition i.e., 19 ± 0.33 mm and 20 ± 0.33 mm for E. coli and S. aureus respectively. The PDM1 and PDM2 have exhibited significant control over bacterial biofilm adhesion as tested by six well plate method. SEM study of bacterial biofilm formation has illustrated that these copolymers act in a similar fashion like cationic biocide. These compositions viz. PDM1 and PDM2, may be useful in development of bioreactors, sensors, surgical equipment and drug delivery devices.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications

et al. 2021

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“…After drying (3), the PMEOx films are subsequently exposed to DCSBD plasma generated in air and argon (4). Since the stability of the prepared PMEOx layer is considered to be a critical parameter; the layer after plasma treatment is thus washed to remove all unattached material (5) and subsequently characterized (6). The main idea of this study is to find the optimal conditions of the plasma (pre-)treatment process, i.e., type of working gas and plasma exposure time for the preparation of stable covalently attached PMEOx layer on PTFE surface for biomedical applications.…”

Section: Resultsmentioning

confidence: 99%

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Šrámková

Zahoranová

Kelar

et al. 2020

Sci Rep

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Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POxbased copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of "cold" homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days. Surface modification of polymers is crucial in many applications, where material must fulfill specific requirements concerning the surface wettability 1 , stiffness 2 , topology 3 as well as chemical reactivity 4. Adjusting the individual surface properties is critical, especially in medicine. Implantable devices or scaffolds must exhibit not only long-term stability in contact with the biological environment but also provide specific interactions with tissues, possess required mechanical or antibacterial properties, or release drugs on demand. Some applications require the material to be non-adhesive and rigid; in other cases, the good cell adhesion is desirable 5. Such control of the specific surface properties of medical implants or devices can be ensured by surface modification 6. The basic strategy for surface modification of low-cost polymers often used in medicine (polypropylene, polyethylene, polytetrafluoroethylene) includes chemical coating by a thin layer of a biocompatible polymer. Besides the polyethylene glycol (PEG) considered being a gold standard for many biomedical applications including surface modification, poly(2-oxazolines) (POx) are gradually more discussed as an available alternative 7,8. POx are accessible via cationic ring-opening polymerization (CROP), which is well controllable process providing the defined polymers with desired architecture, functional moieties, and adjustable properties. Their relevance for employing as biomedical coatings is supported by extensive biological studies of biocompatibility 9,10 , immunotoxicity 11,12 , and control of protein and cell adhesion 13 with positive results. Up to now, many different modification techniqu...

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“…4,10 Compare to inorganic films, biodegradable polymeric films have better properties. 11,12 As naturally biodegradable polymeric material, the poly-β-hydroxybutyrate (PHB) belongs to the family of poly-β-hydroxyalkanoates and has been applied as biodegradable and biocompatible plastics. PHB has good biodegradability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

The effect of composite PHB coating on the biological properties of a magnesium based alloy

Liang

Liu

et al. 2021

J Biomater Appl

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Magnesium alloys have been widely investigated as biodegradable cardiovascular temporal implants due to their better mechanical properties and biocompatibility, but the rapid degradation limited its application. In this study, the anodic oxidation-Cu structure was used to improve the adhesive strength and stability between poly-β-hydroxybutyrate (PHB) and magnesium alloys, and the effects of anodic oxidation magnesium alloys with copper film and PHB film (MACP) on human umbilical vein endothelial cells (HUVECs), blood compatibility and antibacterial properties were investigated in this research. As the result, the MACP structure had a stable structure and better corrosion resistance, and significant antibacterial properties. The coating would not affect the original excellent biocompatibility of the magnesium alloy. It was indicated that MACP was a potential surface modification strategy for vascular stents candidate material.

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Chemical Surface Modification of Polymeric Biomaterials for Biomedical Applications

Cited by 123 publications

References 368 publications

Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications

Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

The effect of composite PHB coating on the biological properties of a magnesium based alloy

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