Abstract:Synthesis of oligosialic acids using 5-N,4-O-carbonyl-protected sialyl donors is described. The cyclic protection of sialyl donor enables an efficient a-sialylation of various acceptors in non-coordinating solvents such as CH 2 Cl 2 . The protection is also effective for improving the reactivity of the hydroxy group at the eight position. In addition, protecting groups of the alcohol in exocyclic side chain affected not only their reactivity towards sialylation but also selectivity in glycosidation. The 7,8 di… Show more
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