1980
DOI: 10.1515/znc-1980-5-602
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Chemical Synthesis of Tropoyl Coenzyme A

Abstract: Tropoyl coenzyme A has been synthesized in good yields via the corresponding N-hydroxysuc-cinimide ester. The UV-spectrum of the purified thioester has an absorption maximum at 257 nm; at this wavelength, a molar extinction coefficient of 19.2 × 106 [cm2 mol-1] has been determined. Upon alkaline hydrolysis of the thioester bond a difference spectrum with Amax at 235 nm (Δe235= 4.8 × 106 [cm2 mol-1]) has been observed. Attempts to prepare 2-phenylmalonyl coenzyme A by the same technique gave negative results.

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Cited by 7 publications
(2 citation statements)
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“…Indeed, despite the synthesis of tropoyl-CoA having been reported by Gross and Koelen (1980), no one has yet apparently been able to measure the transfer of tropate from this thioester to tropine. In view of the conclusions that can be drawn from the data reported in the present communication, it would appear that priority should now be given to establishing the reactions bringing about this conjugation.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, despite the synthesis of tropoyl-CoA having been reported by Gross and Koelen (1980), no one has yet apparently been able to measure the transfer of tropate from this thioester to tropine. In view of the conclusions that can be drawn from the data reported in the present communication, it would appear that priority should now be given to establishing the reactions bringing about this conjugation.…”
Section: Discussionmentioning
confidence: 99%
“…Some early reports claimed that hyoscyamine could be made in vitro by incubating tropine and tropic acid with root extracts [3,4] but these claims have failed to be substantiated. More recently, a number of laboratories have tried this reaction replacing tropic acid with tropylCoA, again without success [5] (T. Hashimoto, personal communication).…”
Section: Introductionmentioning
confidence: 99%