Chemical Topography of the Brain

Randall, Lowell O.

doi:10.1016/s0021-9258(18)74053-2

Cited by 53 publications

(16 citation statements)

References 9 publications

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“…2. The myelin concentrations in the post mortem specimen are representative of the population and comparable to the concentrations reported by Randall (1938);…”

Section: Iron and Myelin Approximationsupporting

confidence: 78%

“…3. The myelin concentrations in white matter reported by Randall (1938) are comparable to the myelin concentration in the internal capsule. Similarly, the myelin concentrations in parietal cortex are comparable to insular cortex.…”

Section: Iron and Myelin Approximationsupporting

confidence: 61%

“…First, iron and myelin contents were approximated using simplified biophysical models (c.f. Hametner et al, 2018;Mangeat, Govindarajan, Mainero, & Cohen-Adad, 2015;Marques, Khabipova, & Gruetter, 2017;Metere & Möller, 2018;Rooney et al, 2007;Stüber et al, 2014), which rely on populationaverage iron and myelin estimates found in the literature (Hallgren & Sourander, 1958;Metere & Möller, 2018;Randall, 1938). Since the amount of structures for which myelin concentrations are known is limited, we also relied on post mortem materials to infer myelin concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…As a reference for myelin concentrations, we used work by Randall (1938), which provides lipid concentrations for the corona radiata, frontal and parietal white matter, brain stem, thalamus, caudate, and frontal and parietal grey matter. Following Metere and Möller (2018), we assumed that these lipid concentrations reflect myelin concentrations.…”

Section: Iron and Myelin Approximationmentioning

confidence: 99%

“…Unfortunately, the reported regions do not include iron-rich nuclei, which limits the range of (especially) R2 * and QSM values with known corresponding lipid concentrations. Using a limited number of regions of interest to estimate the myelin model could limit the generalizability of the estimated parameters to structures with lower R2 * and/or QSM values, which would bias myelin estimates in iron-rich structures like some basal ganglia nodes (e.g., based on using only Randall's (1938) lipid concentrations, Metere and Möller (2018) obtained negative myelin concentrations in various basal ganglia structures).…”

Section: Iron and Myelin Approximationmentioning

confidence: 99%

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Charting human subcortical maturation across the adult lifespan within vivo7 T MRI

Miletić¹,

Bazin

Isherwood³

et al. 2021

Preprint

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The human subcortex comprises hundreds of unique structures. Subcortical functioning is crucial for behavior, and disrupted subcortical function is observed in common neurodegenerative diseases. De- spite their importance, human subcortical structures continue to be difficult to study in vivo. Here, we zoom in on 17 prominent subcortical structures, by describing their approximate iron and myelin contents and thickness, and by providing detailed accounts of their age-related changes across the normal adult lifespan. The results provide compelling insights into the highly heterogeneous mor- phometry and intricate age-related variations of these structures. They also show that the locations of these structures shift across the lifespan, which is of direct relevance for the use of standard magnetic resonance imaging atlases. The results further our understanding of subcortical morphometry and neuroimaging properties, and of normal aging processes which ultimately can improve understanding of neurodegeneration.

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“…2. The myelin concentrations in the post mortem specimen are representative of the population and comparable to the concentrations reported by Randall (1938);…”

Section: Iron and Myelin Approximationsupporting

confidence: 78%

Section: Iron and Myelin Approximationsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Iron and Myelin Approximationmentioning

confidence: 99%

Section: Iron and Myelin Approximationmentioning

confidence: 99%

See 3 more Smart Citations

Charting human subcortical maturation across the adult lifespan within vivo7 T MRI

Miletić¹,

Bazin

Isherwood³

et al. 2021

Preprint

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Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents

et al. 2001

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Emission tomographic measurement of local cerebral blood flow in humans by an in vivo autoradiographic strategy

1984

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An in vivo autoradiographic strategy is described for the measurement of local cerebral blood flow in humans by positron emission tomography, based on an application of the single-compartment model originally proposed by Kety. A variety of factors are considered upon which the successful quantitation of local blood flow depends. These factors include the mode of tracer administration and the definition of the arterial input function; the choice of scan parameters to assure unique and sensitive values of flow throughout the physiological range of interest; the influence of these parameters on the stability and signal/noise characteristics of the computed flow; the error introduced by the presence of heterogeneity of flow within a volume element; and factors related to the choice of the radiotracer itself. The in vivo autoradiographic method is compared to an alternative local cerebral blood flow method employing continuous inhalation of oxygen-15-labeled carbon dioxide. The general relevance of these issues to all local blood flow methods intended for emission tomographic application is emphasized.

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Chemical Topography of the Brain

Cited by 53 publications

References 9 publications

Charting human subcortical maturation across the adult lifespan within vivo7 T MRI

Charting human subcortical maturation across the adult lifespan within vivo7 T MRI

Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents

Emission tomographic measurement of local cerebral blood flow in humans by an in vivo autoradiographic strategy

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