Chemical Transformations of Chlorophyll a and Possible Areas for Application of Its Derivatives

Миронов, А. Ф.

doi:10.1134/s1070363219090354

Cited by 6 publications

(4 citation statements)

References 75 publications

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“…Several boron-containing chlorophyll a derivatives have been investigated [ 49 ], including chlorins 14 and 1 5 , shown in Figure 6 . Similar to porphyrins, this type of compound also binds to LDL [ 50 ], and as a result typically shows preferential accumulation in tumor cells.…”

Section: Porphyrin Derivatives For Bnctmentioning

confidence: 99%

Multi-Functional Boron-Delivery Agents for Boron Neutron Capture Therapy of Cancers

Oloo,

Smith,

Vicente

2023

Cancers

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Boron neutron capture therapy (BNCT) is a binary cancer treatment that involves the irradiation of 10B-containing tumors with low-energy neutrons (thermal or epithermal). The alpha particles and recoiling Li nuclei that are produced in the 10B-capture nuclear reaction are high-linear-energy transfer particles that destroy boron-loaded tumor cells; therefore, BNCT has the potential to be a localized therapeutic modality. Two boron-delivery agents have been used in clinical trials of BNCT in patients with malignant brain tumors, cutaneous melanoma, or recurrent tumors of the head and neck region, demonstrating the potential of BNCT in the treatment of difficult cancers. A variety of potentially highly effective boron-delivery agents have been synthesized in the past four decades and tested in cells and animal models. These include boron-containing nucleosides, peptides, proteins, polyamines, porphyrins, liposomes, monoclonal antibodies, and nanoparticles of various types. The most promising agents are multi-functional boronated molecules and nanoparticles functionalized with tumor cell-targeting moieties that increase their tumor selectivity and contain a radiolabel or fluorophore to allow quantification of 10B-biodistribution and treatment planning. This review discusses multi-functional boron agents reported in the last decade, but their full potential can only be ascertained after their evaluation in BNCT clinical trials.

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Section: Porphyrin Derivatives For Bnctmentioning

confidence: 99%

Multi-Functional Boron-Delivery Agents for Boron Neutron Capture Therapy of Cancers

Oloo,

Smith,

Vicente

2023

Cancers

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“…Nowadays, of particular importance is the use of tetrapyrrole macroheterocycles for biomedical purposes. Apart from the well-established efficiency of porphyrin-based photodynamic therapy agents [ 6 – 17 ], the ability of these compounds to inactivate various viruses, including SARS-CoV-2, opens prospects of creating new alternative approaches to the treatment of drug-resistant viral and bacterial infections [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the unique properties of chlorophyll a and bacteriochlorophyll a have opened up wide possibilities for creating photosensitizers for antimicrobial and anticancer photodynamic therapy [ 6 , 7 ]. Chemical modification of the peripheral substituents of the original natural macroheterocycle can significantly increase the stability of its derivatives, increase the affinity for malignant neoplasms, and improve physicochemical properties [ 8 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Main Strategies for the Synthesis of meso-Arylporphyrins

Койфман

Агеева

2022

Russ J Org Chem

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meso -Arylporphyrins as most accessible tetrapyrrole macroheterocycles have always been the focus of attention from researchers concerned with practically useful properties of these compounds. The first syntheses of meso -arylporphyrins date back to about 90 years ago. Up to now, the yields of these compounds have been improved from 5 to 80%. The present review analyzes different ways and strategies for the synthesis of meso -aryl-substituted porphyrins. The most efficient methods that can be scaled up to an industrial level have been identified.

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“…Just as no review can claim an absolute coverage of available data in the area under consideration, our review did not consider the results for some specific very important results for MPXs/MPcXs as molecular materials. We are here obliged to cite significant works on the study and the application of the porphyrin/phthalocyanine sensitizers for PDT/diagnostics, [180][181][182][183][184][185][186][187] the catalysts based on the porphyrin/phthalocyanine complexes of rhenium [188][189][190][191] and iridium [192,193] for redox reactions that are beyond the scope of our review, and the shift reagents based on REE porphyrin complexes in NMR. [194][195][196] Regarding our review, that is the first review of the fundamental parameters and the properties of axially bonded MPs/phthalocyanines for use in their molecular material chemistry.…”

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confidence: 99%

Recent progress in organometallic porphyrin‐based molecular materials for optical sensing, light conversion, and magnetic cooling

Ломова

2021

Applied Organom Chemis

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We present the review of fundamental parameters and properties of metalloporphyrins/phthalocyanines with axial covalent M-O/M-N bonds (M is a metal atom in the oxidation degree more than 2+) for use in the development of the chemistry of molecular materials. The porphyrin complexes covalently bonded along the axial axis are differed by the high oxidation state of a metal atom and related heightened axial reactivity compared with the corresponding derivatives of two charged metal cations, applications of which in both scientific studies and practical areas are most widely reflected in publications. The selection of chemical structures of the 3d, 4d, 5d, and 4f metal derivatives of porphyrins/phthalocyanines and study of their properties promising in the detection of bioactive organic bases, optoelectronics (active components of allsmall molecular organic solar cells), and spintronics (room-temperature magnetocaloric materials) are detailed in the article. The results of the first critical analysis of this topic in the review and the insight into chemical structure effects in the function of MPXs/MPcXs as molecular materials will contribute to further development of their organometallic chemistry.

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Chemical Transformations of Chlorophyll a and Possible Areas for Application of Its Derivatives

Cited by 6 publications

References 75 publications

Multi-Functional Boron-Delivery Agents for Boron Neutron Capture Therapy of Cancers

Multi-Functional Boron-Delivery Agents for Boron Neutron Capture Therapy of Cancers

Main Strategies for the Synthesis of meso-Arylporphyrins

Recent progress in organometallic porphyrin‐based molecular materials for optical sensing, light conversion, and magnetic cooling

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