Chemical warfare agents simulants detection with an optimized SAW sensor array

Matatagui, Daniel; Martí, J.; Fernández, M.; Fontecha, J.; Gutiérrez, Juan Manuel; Gràcia, I.; Cané, C.; Horrillo, M.C.

doi:10.1016/j.snb.2010.01.057

Cited by 87 publications

(68 citation statements)

References 15 publications

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“…The loaded Q-factor for the uncoated devices was ∼7500, while the obtained loaded Q-factors after protein depositions were greater than ∼5500. These results provided a suitable frequency stability for the electronic oscillators and were in line with those obtained with drop casting depositions (Di Pietrantonio et al, 2013) and with those achieved for optimised depositions of polymers (Matatagui et al, 2011;McGill et al, 1998). These findings support the feasibility of the LIFT for the deposition of proteins on SAW resonators.…”

Section: Obp Coating Assessment By Electrical Characterisation Of Sawsupporting

confidence: 86%

A surface acoustic wave bio-electronic nose for detection of volatile odorant molecules

Pietrantonio

Benetti

Cannatà

et al. 2015

Biosensors and Bioelectronics

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Section: Obp Coating Assessment By Electrical Characterisation Of Sawsupporting

confidence: 86%

A surface acoustic wave bio-electronic nose for detection of volatile odorant molecules

Pietrantonio

Benetti

Cannatà

et al. 2015

Biosensors and Bioelectronics

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“…Major directions of the advancement include (i) the optimization of sensing layer properties and coupling of the layers with analytes and piezoelectric substrates [91]; (ii) the control of the undesired effects and drifts that can arise from the devices itself, the environment, and the measurement system [91]; (iii) application for detecting and monitoring a range of gases, VOCs, and CWAs at different operating conditions [66,95]; and (iv) integration with electronics and improvement in signal analysis. Below, we discuss some of these advances.…”

Section: Advances In Saw-based Chemical Sensingmentioning

confidence: 99%

SAW Sensors for Chemical Vapors and Gases

Devkota

Ohodnicki

Greve

2017

Sensors

229

147

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Surface acoustic wave (SAW) technology provides a sensitive platform for sensing chemicals in gaseous and fluidic states with the inherent advantages of passive and wireless operation. In this review, we provide a general overview on the fundamental aspects and some major advances of Rayleigh wave-based SAW sensors in sensing chemicals in a gaseous phase. In particular, we review the progress in general understanding of the SAW chemical sensing mechanism, optimization of the sensor characteristics, and the development of the sensors operational at different conditions. Based on previous publications, we suggest some appropriate sensing approaches for particular applications and identify new opportunities and needs for additional research in this area moving into the future.

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“…[16][17][18][19][20] Esses compostos têm como alvo principal a AChE. 17,21 Recentemente, um ataque na Síria (agosto de 2013) com o neurotóxico sarin alertou mais uma vez a opinião pública mundial e a comunidade científica para a utilização de armas químicas.…”

Section: Os Neurotóxicosunclassified

Chemical Warfare: Perspectives on Reactivating the Enzyme Acetylcholinesterase Inhibited by Organophosphates

Giacoppo¹,

Lima²,

Kuča³

et al. 2014

Revista Virtual De Química

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Recent attacks on Syria using the nerve agent sarin warned once again the world and the scientists on the use of chemical weapons. It is known that nerve agents are potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine and, thus, transmitting of nerve impulses. The process of AChE inhibition by organophosphate (OP) can be reversed by a nucleophile, responsible for dephosphorylation of the residue Ser203 in the active site of the enzyme. In this sense, oximes exhibit this characteristic and are able to remove the neurotoxic and reactivate the enzyme. Here, we review experimental and theoretical results involving docking and quantum mechanical-molecular mechanics hybrid methods (QM/MM), using Molegro® and Spartan® softwares to analyze the interaction of different OPs and oximes with AChE and to evaluate kinetic constants of reactivation.Keywords: Chemical warfare; organophosphates; oximes; docking; QM/MM. ResumoOs ataques recentes na Síria utilizando o agente neurotóxico sarin alertaram mais uma vez a opinião pública mundial e a comunidade científica quanto à utilização de armas químicas. Sabe-se que agentes dos nervos são potentes inibidores da acetilcolinesterase (AChE), enzima responsável pela hidrólise do neurotransmissor acetilcolina e, consequentemente, pela transmissão de impulsos nervosos. A inibição da AChE por um organofosforado (OP) pode ser revertida por um nucleófilo, que desfosforila a Ser203 no sítio ativo da enzima. Nesse sentido, as oximas têm essa característica, pois são capazes de remover o neurotóxico e reativar a enzima. Neste trabalho, revisamos alguns resultados experimentais e teóricos que envolvem estudos de ancoramento molecular e métodos híbrídos quanto-mecânicos/mecânica molecular (QM/MM) usando os softwares Molegro® e Spartan® para analisar as interações de diferentes oximas e OPs com a AChE e avaliar as constantes cinéticas de reativação.Palavras-chave: Guerra química; organofosforados; oximas; ancoramento; QM/MM.

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Chemical warfare agents simulants detection with an optimized SAW sensor array

Cited by 87 publications

References 15 publications

A surface acoustic wave bio-electronic nose for detection of volatile odorant molecules

A surface acoustic wave bio-electronic nose for detection of volatile odorant molecules

SAW Sensors for Chemical Vapors and Gases

Chemical Warfare: Perspectives on Reactivating the Enzyme Acetylcholinesterase Inhibited by Organophosphates

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