Chemically amplified cytochrome P450-2E1 drug metabolism nanobiosensor for rifampicin anti-tuberculosis drug

Ajayi, Rachel Fanelwa; Sidwaba, Unathi; Feleni, Usisipho; Douman, Samantha F.; Tovide, Oluwakemi; Botha, Subelia; Baker, Priscilla; Fuku, Xolile; Hamid, Sara Hamid Ibrahim; Waryo, Tesfaye; Vilakazi, Sibulelo; Tshihkudo, Robert; Iwuoha, Emmanuel I.

doi:10.1016/j.electacta.2013.12.147

Cited by 26 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RIF is the most powerful first-line anti-TB drug, characterized as a highly effective, orally administered and non-toxic compound, as part of the combined therapy approach recommended by the WHO [ 23 ]. RIF has an effectiveness of about 95% in cases of TB caused by susceptible strains [ 47 ], with a daily oral administration of the standard 600 mg single dose [ 24 , 48 ] or of a dose corresponding to 10–20 mg RIF/kg body weight [ 49 , 50 ]. Alone or in combination with other drugs, it represents the main treatment for infections (produced by various microorganisms), such as TB ( Mycobacteria tuberculosis ), osteomyelitis ( Staphylococcus aureus ), meningococcal disease ( Neisseria meningitidis ), leprosy ( Mycobacterium leprae ), gonorrhea ( Neisseria gonorrhoeae ) [ 51 ], Legionnaire’s disease ( Legionella pneumophila) [ 19 , 28 ] and even HIV [ 52 , 53 ].…”

Section: Rifamycins—properties and Clinical Treatmentmentioning

confidence: 99%

“…RIF bioavailability and, therefore, its therapeutic action can be influenced by its physical or chemical interactions with other molecules (peptides, DNA, drugs, nutrients, etc.). Various electrochemical [ 23 , 50 , 89 , 90 ] and spectrometric (optical or luminescence) [ 30 , 91 , 92 , 93 , 94 ] methods have been reported to be applied to investigate such interactions [ 43 , 95 , 96 ].…”

Section: Rifamycins Detection and Monitoringmentioning

confidence: 99%

See 1 more Smart Citation

State of the Art on Developments of (Bio)Sensors and Analytical Methods for Rifamycin Antibiotics Determination

Noor

David

Jinga

et al. 2023

Sensors

View full text Add to dashboard Cite

This review summarizes the literature data reported from 2000 up to the present on the development of various electrochemical (voltammetric, amperometric, potentiometric and photoelectrochemical), optical (UV-Vis and IR) and luminescence (chemiluminescence and fluorescence) methods and the corresponding sensors for rifamycin antibiotics analysis. The discussion is focused mainly on the foremost compound of this class of macrocyclic drugs, namely rifampicin (RIF), which is a first-line antituberculosis agent derived from rifampicin SV (RSV). RIF and RSV also have excellent therapeutic action in the treatment of other bacterial infectious diseases. Due to the side-effects (e.g., prevalence of drug-resistant bacteria, hepatotoxicity) of long-term RIF intake, drug monitoring in patients is of real importance in establishing the optimum RIF dose, and therefore, reliable, rapid and simple methods of analysis are required. Based on the studies published on this topic in the last two decades, the sensing principles, some examples of sensors preparation procedures, as well as the performance characteristics (linear range, limits of detection and quantification) of analytical methods for RIF determination, are compared and correlated, critically emphasizing their benefits and limitations. Examples of spectrometric and electrochemical investigations of RIF interaction with biologically important molecules are also presented.

show abstract

Section: Rifamycins—properties and Clinical Treatmentmentioning

confidence: 99%

Section: Rifamycins Detection and Monitoringmentioning

confidence: 99%

State of the Art on Developments of (Bio)Sensors and Analytical Methods for Rifamycin Antibiotics Determination

Noor

David

Jinga

et al. 2023

Sensors

View full text Add to dashboard Cite

show abstract

“…An ethylene glycol bis(succinic acid N-hydroxysuccinimide ester) (EG) CYP2E1-modified gold electrode was designed as a biosensor for the determination of rifampicin [51]. The gold electrode was first modified with a polyvinylpyrrolidone-modified silver nanoparticle/ poly(8-anilino-1-naphthalene sulfonic acid) nanocomposite followed by electrodeposition of EG-CYP2E1 at a potential of 700 mV (versus Ag/AgCl) for 10 min.…”

Section: Gold Electrodesmentioning

confidence: 99%

Surface-modified electrodes in the mimicry of oxidative drug metabolism

Yuan

Permentier

Bischoff

2015

TrAC Trends in Analytical Chemistry

View full text Add to dashboard Cite

“…Examination of the biosensor transducer types in Table 2 [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] reveals an overwhelming amount of research originating from South Africa has been focused on electrochemical (amperometric, impedimetric, potentiometric and voltammetric) configurations of biosensors, with only a few publications found investigating colourimetric/photometric bases for signal generation. This is, itself, due to the many commonly reported beneficial properties of electroanalysis over other transducers—e.g., low fabrication-cost, consistency of fabrication, high degree of alloweable automation, ability to derive multiple signals from a single analytical device (signal multiplexing), lower anal...…”

Section: Transducer Types and Sensor Fabrication Materialsmentioning

confidence: 99%

“…Tuberculosis diagnosis via detection of circulating antibodies generated by the host against the mycolic acids produced by the tuberculosis Mycobacterium [ 33 ] was an important breakthrough for future rapid tests in the country, but certainly worldwide, given the emergence of multi-drug resistant tuberculosis. Biosensor assemblies for detection of drugs used to treat tuberculosis [ 30 , 38 ] and HIV/AIDS [ 24 ] utilising cytochrome p450 assemblies has particular relevance as part of treatment monitoring strategies. Aptamer targeting of tuberculosis markers will certainly support in time efforts in this regard.…”

Section: Targets In Biosensor Developmentmentioning

confidence: 99%

Developing Biosensors in Developing Countries: South Africa as a Case Study

Fogel

Limson

2016

Biosensors

View full text Add to dashboard Cite

A mini-review of the reported biosensor research occurring in South Africa evidences a strong emphasis on electrochemical sensor research, guided by the opportunities this transduction platform holds for low-cost and robust sensing of numerous targets. Many of the reported publications centre on fundamental research into the signal transduction method, using model biorecognition elements, in line with international trends. Other research in this field is spread across several areas including: the application of nanotechnology; the identification and validation of biomarkers; development and testing of biorecognition agents (antibodies and aptamers) and design of electro-catalysts, most notably metallophthalocyanine. Biosensor targets commonly featured were pesticides and metals. Areas of regional import to sub-Saharan Africa, such as HIV/AIDs and tuberculosis diagnosis, are also apparent in a review of the available literature. Irrespective of the targets, the challenge to the effective deployment of such sensors remains shaped by social and economic realities such that the requirements thereof are for low-cost and universally easy to operate devices for field settings. While it is difficult to disentangle the intertwined roles of national policy, grant funding availability and, certainly, of global trends in shaping areas of emphasis in research, most notable is the strong role that nanotechnology, and to a certain extent biotechnology, plays in research regarding biosensor construction. Stronger emphasis on collaboration between scientists in theoretical modelling, nanomaterials application and or relevant stakeholders in the specific field (e.g., food or health monitoring) and researchers in biosensor design may help evolve focused research efforts towards development and deployment of low-cost biosensors.

show abstract

Chemically amplified cytochrome P450-2E1 drug metabolism nanobiosensor for rifampicin anti-tuberculosis drug

Cited by 26 publications

References 18 publications

State of the Art on Developments of (Bio)Sensors and Analytical Methods for Rifamycin Antibiotics Determination

State of the Art on Developments of (Bio)Sensors and Analytical Methods for Rifamycin Antibiotics Determination

Surface-modified electrodes in the mimicry of oxidative drug metabolism

Developing Biosensors in Developing Countries: South Africa as a Case Study

Contact Info

Product

Resources

About