Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb—IV. Intraglomerular synapses of tyrosine hydroxylase-immunoreactive neurons

Toida, Kazunori; Kosaka, Kenzo; Aika, Yusuke; Kosaka, Toshio

doi:10.1016/s0306-4522(00)00356-0

Cited by 92 publications

(121 citation statements)

References 24 publications

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“…Anatomical studies suggest a compartmental organization of the glomeruli, consisting of two subregions, one richly and another poorly targeted by ON terminals (Kosaka et al, 1997;Toida et al, 1998Toida et al, , 2000Kasowski et al, 1999). Because the present findings indicate that as many as 80% of all PG cells lack monosynaptic ON input, this suggests that most PG cells are functionally associated with glomerular compartments lacking ON terminals.…”

Section: Juxtaglomerular Neurons and Glomerular Circuitrysupporting

confidence: 47%

“…Because the present findings indicate that as many as 80% of all PG cells lack monosynaptic ON input, this suggests that most PG cells are functionally associated with glomerular compartments lacking ON terminals. Calbindin-positive JG neurons extend their dendrites only into glomerular compartments devoid of ON terminals, suggesting that they do not receive direct sensory innervation (Toida et al, , 2000. Thus, some PG cells lacking ON input in the present study may be calbindin positive.…”

Section: Juxtaglomerular Neurons and Glomerular Circuitrymentioning

confidence: 60%

“…Mitral/tufted cells may also relay ON input to PG/SA cells as they form asymmetrical excitatory dendrodendritic synapses with JG neurons (Pinching and Powell, 1971a,b;Toida et al, 1998Toida et al, , 2000Kasowski et al, 1999). However, because (1) SA/PG cells receive spontaneous and ON-evoked bursts of EPSPs, (2) ET cells, but not mitral cells, spontaneously generate spike bursts in vitro (Heyward et al, 2001;Hayar et al, 2004), and (3) ET cells provide monosynaptic (Hsia et al, 1999;Wachowiak and Cohen, 1999;Aroniadou-Anderjaska et al, 2000;Ennis et al, 2001).…”

Section: Juxtaglomerular Neurons and Glomerular Circuitrymentioning

confidence: 99%

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External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity

Hayar

Karnup

Ennis³

et al. 2004

J. Neurosci.

218

354

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Section: Juxtaglomerular Neurons and Glomerular Circuitrysupporting

confidence: 47%

Section: Juxtaglomerular Neurons and Glomerular Circuitrymentioning

confidence: 60%

Section: Juxtaglomerular Neurons and Glomerular Circuitrymentioning

confidence: 99%

See 1 more Smart Citation

External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity

Hayar

Karnup

Ennis³

et al. 2004

J. Neurosci.

218

354

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“…Immunofluorescence of brain slices was performed according to a previously described protocol [23]. The following primary antibodies were used: phospho-Histone H3 (PH3) (rabbit, 1:500; Upstate), Tuj1 (mouse, 1:500; Covance), VGluT2 (rabbit, 1:250) [24], GFP (chick, 1:500; Aves Labs or chick, 1:1,000; Abcam), Pax6 (rabbit, 1:500; Covance), Tbr2 (rabbit, 1:500; Abcam), CD24 (rat, 1:200; BD), MAP2 (rabbit, 1:250; Abcam), Ctip2 (rat, 1:200; Abcam), Satb2 (mouse, 1:200; Abcam), and all human nuclei (mouse, 1:1,000; Chemicon).…”

Section: Immunofluorescencementioning

confidence: 99%

Novel and Robust Transplantation Reveals the Acquisition of Polarized Processes by Cortical Cells Derived from Mouse and Human Pluripotent Stem Cells

Nagashima

Suzuki

Shitamukai

et al. 2014

Stem Cells and Development

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Current stem cell technologies have enabled the induction of cortical progenitors and neurons from embryonic stem cells (ESCs) and induced pluripotent stem cells in vitro. To understand the mechanisms underlying the acquisition of apico-basal polarity and the formation of processes associated with the stemness of cortical cells generated in monolayer culture, here, we developed a novel in utero transplantation system based on the moderate dissociation of adherens junctions in neuroepithelial tissue. This method enables (1) the incorporation of remarkably higher numbers of grafted cells and (2) quantitative morphological analyses at single-cell resolution, including time-lapse recording analyses. We then grafted cortical progenitors induced from mouse ESCs into the developing brain. Importantly, we revealed that the mode of process extension depends on the extrinsic apicobasal polarity of the host epithelial tissue, as well as on the intrinsic differentiation state of the grafted cells. Further, we successfully transplanted cortical progenitors induced from human ESCs, showing that our strategy enables investigation of the neurogenesis of human neural progenitors within the developing mouse cortex. Specifically, human cortical cells exhibit multiple features of radial migration. The robust transplantation method established here could be utilized both to uncover the missing gap between neurogenesis from ESCs and the tissue environment and as an in vivo model of normal and pathological human corticogenesis.

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“…The PG cells project short dendrites within a single glomerulus. There are GABA-positive and GABA-negative PG cells: GABA-positive PG cells are connected with projection fibers of OSNs through synapses, which are called Type 1-PG cells, whereas GABAnegative PG cells are not connected with OSN projections and are called Type 2-PG cells [28,57,58]. The SA cells have very long dendrites compared with other JGCs and extend their dendrites about 20-30 glomeruli away from their cell bodies [2].…”

Section: Morphology Of Juxtaglomerular Cells (Jgcs)mentioning

confidence: 99%

Histological Properties of the Glomerular Layer in the Mouse Accessory Olfactory Bulb

Yokosuka

2012

Exp. Anim.

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Abstract:In mammals, the vomeronasal system (VS) originating from the vomeronasal organ (VNO; also called "Jacobson's organ") is considered to be a chemosensory system that recognizes "pheromone" signals. In the accessory olfactory bulb (AOB), the primary center of the VS, the glomerular cell layer (GL) of the AOB is regarded as an important functional area in the transmission of pheromone signals from vomeronasal sensory neurons (VSNs) of the VNO. In mice, the most frequently used animal model for the study of the VS, the GL of the AOB has several unique histological properties when compared with the main olfactory bulb (MOB): (i) each glomerular size is far smaller than in the MOB; (ii) many juxtaglomerular cells (JGCs) are GABA immunopositive, but subpopulations of cells distributed in the AOB are tyrosine hydroxylase-or calcium-binding protein immunopositive; and (iii) the dendritic branching pattern of the JGC in the AOB is heteromeric. The biological significance of the mammalian VS is still debated. The unique histological properties of the mouse AOB summerized in the present review may give some useful information that may help in understanding the function of the mammalian VS.

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Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb—IV. Intraglomerular synapses of tyrosine hydroxylase-immunoreactive neurons

Cited by 92 publications

References 24 publications

External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity

External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity

Novel and Robust Transplantation Reveals the Acquisition of Polarized Processes by Cortical Cells Derived from Mouse and Human Pluripotent Stem Cells

Histological Properties of the Glomerular Layer in the Mouse Accessory Olfactory Bulb

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