Chemically engineered persistent luminescence nanoprobes for bioimaging

L’Ecuyer, Thomas; Teston, Eliott; Ramírez-García, Gonzalo; Maldiney, Thomas; Viana, Bruno; Séguin, Johanne; Mignet, Nathalie; Scherman, Daniel; Richard, Cyrille

doi:10.7150/thno.16589

Cited by 171 publications

(110 citation statements)

References 140 publications

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“…The fast moving field of lanthanide‐containing luminescent nanoparticles has been the subject of many recent reviews covering subjects as diverse as fundamental properties, synthesis, biosensing, bioimaging, drug delivery and theranostics, as well as persistent luminescence nanoparticles, NIR‐emitting nanoparticles, and forensic or other applications . The present review focuses on biological/medical applications and on lighting/displays, two main sectors in which nanomaterials have brought significant advances recently.…”

Section: Introductionmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.

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Section: Introductionmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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145

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“…The dimensions of the grains in the nano-sized regime, in combination with the spectral location of the emission, provides the phosphor with characteristics for applications such as optical imaging in biomedicine. However, the surface must be functionalized in order to render the nanoparticles stable in aqueous media [17,18,19]. …”

Section: Introductionmentioning

confidence: 99%

Counting the Photons: Determining the Absolute Storage Capacity of Persistent Phosphors

et al. 2017

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The performance of a persistent phosphor is often determined by comparing luminance decay curves, expressed in cd/m2. However, these photometric units do not enable a straightforward, objective comparison between different phosphors in terms of the total number of emitted photons, as these units are dependent on the emission spectrum of the phosphor. This may lead to incorrect conclusions regarding the storage capacity of the phosphor. An alternative and convenient technique of characterizing the performance of a phosphor was developed on the basis of the absolute storage capacity of phosphors. In this technique, the phosphor is incorporated in a transparent polymer and the measured afterglow is converted into an absolute number of emitted photons, effectively quantifying the amount of energy that can be stored in the material. This method was applied to the benchmark phosphor SrAl2O4:Eu,Dy and to the nano-sized phosphor CaS:Eu. The results indicated that only a fraction of the Eu ions (around 1.6% in the case of SrAl2O4:Eu,Dy) participated in the energy storage process, which is in line with earlier reports based on X-ray absorption spectroscopy. These findings imply that there is still a significant margin for improving the storage capacity of persistent phosphors.

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“…To overcome this parasitic signal, our group pioneered the use of persistent luminescent nanoparticles (PLNPs) for in vivo imaging. Acting as optical capacitors, PLNPs can emit light in the tissue transparency window for minutes to hours after the end of an UV or visible illumination, leading to signals without autofluorescence and high target to background ratio . Recently, ultrasensitive detection of labeled cells in small animals either after intravenous or subcutaneous injection was demonstrated in preliminary studies using PLNPs …”

Section: Introductionmentioning

confidence: 99%

Nanohybrids with Magnetic and Persistent Luminescence Properties for Cell Labeling, Tracking, In Vivo Real‐Time Imaging, and Magnetic Vectorization

Teston

Maldiney

Marangon

et al. 2018

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Once injected into a living organism, cells diffuse or migrate around the initial injection point and become impossible to be visualized and tracked in vivo. The present work concerns the development of a new technique for therapeutic cell labeling and subsequent in vivo visualization and magnetic retention. It is hypothesized and subsequently demonstrated that nanohybrids made of persistent luminescence nanoparticles and ultrasmall superparamagnetic iron oxide nanoparticles incorporated into a silica matrix can be used as an effective nanoplatform to label therapeutic cells in a nontoxic way in order to dynamically track them in real-time in vitro and in living mice. As a proof-of-concept, it is shown that once injected, these labeled cells can be visualized and attracted in vivo using a magnet. This first step suggests that these nanohybrids represent efficient multifunctional nanoprobes for further imaging guided cell therapies development.

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Chemically engineered persistent luminescence nanoprobes for bioimaging

Cited by 171 publications

References 140 publications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Counting the Photons: Determining the Absolute Storage Capacity of Persistent Phosphors

Nanohybrids with Magnetic and Persistent Luminescence Properties for Cell Labeling, Tracking, In Vivo Real‐Time Imaging, and Magnetic Vectorization

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