Chemically Exfoliated MoS<sub>2</sub> as Near‐Infrared Photothermal Agents

Kaehr, Bryan; Brinker, C. Jeffrey; Chou, Stanley S.; Kim, Jaemyung; Foley, Brian M.; De, Mrinmoy; Hopkins, Patrick E.; Huang, Jiaxing; Dravid, Vinayak P.

doi:10.1002/ange.201209229

Cited by 222 publications

(181 citation statements)

References 51 publications

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“…Because of their intense localized surface plasmon resonances, single-or few-layer MoS 2 nanosheets displayed an absorbance profile reaching the NIR region, where biological systems are maximally transparent. 12,13 This intrinsic physical property contributes to the excellent photothermal conversion efficacy of MoS 2 nanosheets under 808-nm laser irradiation. In our study, the newly synthesized MoS 2 nanosheets were efficiently grown on the strut surfaces of AKT scaffolds, endowing the scaffolds with excellent 'inherent' photothermal-transducing ability.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14] Chou et al 13 first demonstrated that MoS 2 nanosheets exhibited~7.8 times greater absorbance in the NIR region than graphene oxides, and their mass extinction coefficient (λ = 800 nm, 29.2 lg − 1 ) was comparable to that of reduced graphene oxides (24.6 lg − 1 cm − 1 ). In addition, previous studies have demonstrated that MoS 2 nanosheets possessed excellent photothermal therapeutic effects on tumors both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

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A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Wang

et al. 2017

NPG Asia Mater

140

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The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS 2 nanosheets were grown in situ on the strut surface of bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS 2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Wang

et al. 2017

NPG Asia Mater

140

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“…Therefore, as a representative, we selected NIR laser with a wavelength of 808 nm as the power source for in vitro and in vivo PTT study. Similar to the "bottom-up" synthesized 16 or "top-down" exfoliated [12][13][14] MoS 2 nanosheets, SP-MoS 2 nanosheets can not only efficiently absorb NIR laser (wavelength: 700-1100 nm, Figure 2B) but also transform the absorbed laser into heat. The photothermal behavior of SP-MoS 2 nanosheets is closely related to the Mo concentration and laser power density ( Figure 5A and B), ie, the temperature increment (∆T) increased with Mo concentration and power density.…”

Section: Discussionmentioning

confidence: 95%

Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor

Gong

Zhou

et al. 2016

IJN

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Two-dimensional MoS 2 nanosheet has been extensively explored as a photothermal agent for tumor regression; however, its surface modification remains a great challenge. Herein, as an alternative to surface polyethylene glycol modification (PEGylation), a facile approach based on “thin-film” strategy has been proposed for the first time to produce soybean phospholipid-encapsulated MoS 2 (SP-MoS 2 ) nanosheets. By simply vacuum-treating MoS 2 nanosheets/soybean phospholipid/chloroform dispersion in a rotary evaporator, SP-MoS 2 nanosheet was successfully constructed. Owing to the steric hindrance of polymer chains, the surface-coated soybean phospholipid endowed MoS 2 nanosheets with excellent colloidal stability. Without showing detectable in vitro and in vivo hemolysis, coagulation, and cyto-/histotoxicity, the constructed SP-MoS 2 nanosheets showed good photothermal conversion performance and photothermal stability. SP-MoS 2 nanosheet was shown to be a promising platform for in vitro and in vivo breast tumor photothermal therapy. The produced SP-MoS 2 nanosheets featured low cost, simple fabrication, and good in vivo hemo-/histocompatibility and hold promising potential for future clinical tumor therapy.

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“…A number of materials, with high optical absorbance in the NIR region, have been developed for laserinduced heat, including plasma nanostructure, carbon-based material, and the other novel inorganic materials. [15][16][17][18][19][20] The ultrahigh flexibility, high thermal conductivity 21 and thermal stability of graphene inspired us to imagine that significant progress could be made for the utilization of graphene film as the suitable candidate for thin film heater. [22][23][24][25][26][27] The flexible graphene film present an extremely rapid temperature response and maintain an excellent photothermal conversion stability by remote nearinfrared laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

Nondestructive rubbing fabrication of flexible graphene film for precise temperature controlling

2017

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The high-quality flexible graphene thin films have been fabricated by the nondestructive rubbing method. The film exhibits an excellent photothermal conversion ability after oxygen plasma treatment and multiple mechanical bending. The temperature can be increased to 47.4°C even under a low laser irradiation power of 240mW with a decent heating rate of 0.3°C/s, and photothermal conversion efficiency reaches as high as 28%. The steady-state temperature can be precisely tuned by changing the laser power. These excellent results indicate graphene-based photothermal elements holding great promise for practical applications.

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Chemically Exfoliated MoS₂ as Near‐Infrared Photothermal Agents

Cited by 222 publications

References 51 publications

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor

Nondestructive rubbing fabrication of flexible graphene film for precise temperature controlling

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Chemically Exfoliated MoS2 as Near‐Infrared Photothermal Agents

Cited by 222 publications

References 51 publications

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor

Nondestructive rubbing fabrication of flexible graphene film for precise temperature controlling

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Chemically Exfoliated MoS₂ as Near‐Infrared Photothermal Agents