Chemically modified DNA nanostructures for drug delivery

Wang, Yuan; Lu, Xuehe; Wu, Xiaohui; Li, Yan; Tang, Wantao; Yang, Changping; Li, Jianbing; Ding, Baoquan

doi:10.1016/j.xinn.2022.100217

Cited by 20 publications

(27 citation statements)

References 127 publications

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“…The use of uniformed DNA nanostructures as a template for the site-specific loading and targeting groups of chemotherapeutic medicines is demonstrated in this report. [13]…”

Section: Monomethyl Auristatin E (Mmae)mentioning

confidence: 99%

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DNA Nanostructures in Pharmaceutical Applications

et al. 2022

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DNA nanostructures have evolved in various ways throughout the years since their discovery, including their structures and functions. Because DNA is a component of the biological system, it may be utilized to deliver therapeutic molecules without causing any harm to the body. For delivery, DNA nanostructures offer several benefits over conventional nanomaterials such as liposomes, polymers gold nanoparticles, carbon materials, etc. Various therapeutic molecules like drugs, nucleic acids, proteins, and a combination of these agents can be delivered with the help of DNA nanostructures.Because of the ease with which nanostructures can be synthesized through self-assembly and the ability to form a variety of shapes, they have found widespread application in biomedical fields. In this review, we will look at the different classes of compounds that are delivered via DNA nanostructures.

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“…The use of uniformed DNA nanostructures as a template for the site-specific loading and targeting groups of chemotherapeutic medicines is demonstrated in this report. [13]…”

Section: Monomethyl Auristatin E (Mmae)mentioning

confidence: 99%

“…[21] The different therapeutic agents can be introduced to the DNA nanostructures by base-pairing hybridization or by chemical covalent cross-linking (Figure 3). [13]…”

Section: Nucleic Acidsmentioning

confidence: 99%

DNA Nanostructures in Pharmaceutical Applications

et al. 2022

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“…After that, pure DNA hydrogels formed only by cross-linking of preformed DNA monomers or rolling circle amplification were also developed. − DNA hydrogels have predictable structures, adjustable mechanical strength, and a large number of binding sites, which make them excellent carriers applied in regulated drug delivery. , Moreover, systematic evolution of ligands by exponential enrichment (SELEX), which originated in the 1990s, has also broadened the applications of DNA. − A variety of DNA aptamers selected from random DNA sequences via SELEX can specifically bind with small molecules, proteins, and even cells. − This antibody-like function makes DNA aptamers have potential in bioanalysis and targeted drug delivery . In addition, various kinds of chemical groups, such as reactive groups, fluorophores, lipids, etc., can be modified on DNA molecules, thereby further extending the functions of DNA. , …”

Section: Introductionmentioning

confidence: 99%

“…40 In addition, various kinds of chemical groups, such as reactive groups, fluorophores, lipids, etc., can be modified on DNA molecules, thereby further extending the functions of DNA. 41,42 Human immune systems play a vital role in fighting against many serious diseases. 43 In recent years, many excellent works have emerged on the applications of functional DNA materials in immunomodulatory therapy.…”

Section: Introductionmentioning

confidence: 99%

Applications of Functional DNA Materials in Immunomodulatory Therapy

Shen

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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In recent years, nanoscale or microscale functional materials derived from DNA have shown great potential for immunotherapy as superior delivery carriers. DNA nanostructures with excellent programmability and addressability enable the precise assembly of molecules or nanoparticles. DNA hydrogels have predictable structures and adjustable mechanical strength, thus being advantageous in controllable release of cargos. In addition, utilizing systematic evolution of ligands by exponential enrichment technology, a variety of DNA aptamers have been screened for specific recognition of ions, molecules, and even cells. Moreover, a wide variety of chemical modifications can further enrich the function of DNA. The unique advantages of functional DNA materials make them extremely attractive in immunomodulation. Recently, functional DNA materials-based immunotherapy has shown great potential in fighting against many diseases like cancer, viral infection, and inflammation. Therefore, in this review, we focus on discussing the progress of the applications of functional DNA materials in immunotherapy; before that, we also summarize the characteristics of the functional DNA materials descried above. Finally, we discuss the challenges and future opportunities of functional DNA materials in immunomodulatory therapy.

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“…23,24 Similar to lipoproteins, 25 lipoprotein-like complexes, 26 and lipid droplet encapsulation, 27 functionalized DNA nanostructures with con ned nonpolar pockets have recently been designed to encapsulate hydrophobic cargo. [28][29][30][31] Typically, DNA strands are functionalized with alkyl chains at a speci c location within the nanostructure. Upon assembly, a hydrophobic compartment is generated with the ability to encapsulate nonpolar cargo such as hydrophobic drugs 32 .…”

Section: Introductionmentioning

confidence: 99%

Functionalized DNA tetrahedron for concomitant delivery of doxorubicin and paclitaxel

Eymael

Carneiro

Magalhães

2022

Preprint

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Breast cancer is a complex disease and the most common cancer among women. Chemotherapy is commonly used in patients with late-stage breast cancer, which can lead to significant adverse effects. The development of new drug delivery systems is fundamental to improving survival and decreasing morbidity for these patients. Previous studies have shown promising results using DNA nanostructures for doxorubicin (DOX) delivery into drug-resistant breast cancer cells. Here, we successfully modify a DNA tetrahedron (TDN) to include alkyl chains attached to the core of the nanostructure for encapsulation of the hydrophobic drug paclitaxel (PTX). The functionalized TDN (fTDN) simultaneously delivered PTX and DOX into MCF7 cells, leading to improved cell death compared to freely diluted drugs. Our fTDN is a stable and effective delivery system that allows dual drug delivery and shows encouraging results for improving breast cancer chemotherapy.

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Chemically modified DNA nanostructures for drug delivery

Cited by 20 publications

References 127 publications

DNA Nanostructures in Pharmaceutical Applications

DNA Nanostructures in Pharmaceutical Applications

Applications of Functional DNA Materials in Immunomodulatory Therapy

Functionalized DNA tetrahedron for concomitant delivery of doxorubicin and paclitaxel

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