Chemically revised conducting polymers with inflammation resistance for intimate bioelectronic electrocoupling

Swertia L.: A comprehensive review of its genetic relationship, chemical compositions, pharmacological effects, toxicities, and applications

“…Inflammation is a very common and important basic pathological process, a defensive response of the organism to stimuli, manifested by redness, swelling, heat, pain, and dysfunction, which is present throughout the pathogenesis of diverse diseases (Qian et al, 2023). S. chirayita can inhibit the release of pro‐inflammatory factors by blocking the activation of cyclooxygenase‐2 (COX‐2).…”

Construction of highly hydrated and mechanically strong anti-fouling coatings for deep-sea probes based on poly(vinyl alcohol) tannic acid zwitterion coatings

“…More importantly, ZI polymers have demonstrated superior resistance to the attachment of non-specific proteins, bacteria and other biological impurities. 12 Sulfobetaine methacrylate (SBMA), 2-methacryloyloxyethyl phosphorylcholine (MPC), and carboxybetaine methacrylate (CBMA) are the three ZI monomers that have received the greatest attention in the literature. 11 Compared to CBMA polymers, SBMA polymers exhibit more and stronger zwitterion-zwitterion interactions.…”

“…11 Compared to CBMA polymers, SBMA polymers exhibit more and stronger zwitterion-zwitterion interactions. 12 Numerous methods for creating antifouling surfaces have been developed to this date based on zwitterionic polymers, 13 such as blending, 14 surface hydrogel coating, 15 surface grafting, 16 layer-by-layer self-assembly 17 and so on. 18 However, zwitterionic polymers' exceptional hydratability also makes it challenging to deposit them onto material surfaces, which has turned into a significant obstacle for their practical application.…”

Simultaneous Presentation of Dexamethasone and Nerve Growth Factor via Layered Carbon Nanotubes and Polypyrrole to Interface Neural Cells

“…Various strategies have been developed to improve the long-term and high-performance neural signal recording/stimulation, such as using soft electrode materials, surface coating with conductive polymers, local release or presentation of anti-inflammatory drugs, or neural growth promoted biomolecules. − Studies indicated that controlling the inflammatory reactions at the electrode sites or stimulating the growth of neural cells and extension of neurites are key points for the maintenance of electrode functions. , The acute and chronic inflammatory response is a key factor accounting for the failure of neural electrodes in long-term functionalization, and the inflammatory response could be modulated via the administration of anti-inflammatory drugs . Dexamethasone (Dex), a synthetic glucocorticoid, is associated with diminished migration and activation of immune cells, upregulation of anti-inflammatory cytokines, and decreased collagen production at the implant site. − Dex has been locally delivered to the microelectrode implanted sites via integrated microfluidic channels, conductive polymer controlled release, or hydrogel transportation, leading to a significantly decreased number of reactive astrocytes and reduced foreign body reactions. , However, the fabrication of microfluidic channels adds to the complexity in electrode fabrication; a limited amount of Dex could be delivered via the conductive polymer copolymerization, and the expansion of nonconductive hydrogels adds to the distance between neurons and neural electrodes.…”