Chemically vapor deposited polymer nanolayers for rapid and controlled permeation of molecules and ions

Gleason, Karen K.

doi:10.1116/1.5132851

Cited by 18 publications

(25 citation statements)

References 118 publications

(143 reference statements)

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“…Characteristics length scales can be tuned with sub-0.1 nm precisions for the average mesh sizes of crosslinked iCVD hydrogels ( Table 3 ) (Yagüe and Gleason, 2012 ; Armagan and Ozaydin Ince, 2015 ; Unger et al, 2016 ). The mesh openings allow the permeation of the species to be released (Gleason, 2020a ). Larger mesh dimensions increase the release rate.…”

Section: Icvd Polymer Composition and Designmentioning

confidence: 99%

“…The mechanistically-based iCVD approach provides full retention of a monomer's organic functional groups and thus enables a rational basis for designing and optimizing film characteristics. The full retention of organic functional groups by iCVD polymerization is essential for the fabrication of smart layers capable of switching permeation behavior in response to variations in light, pH, or temperature (Gleason, 2020a , b ). The ability to synthesis biodegradable and biocompatible iCVD polymers is also desired for controlled release applications requiring systems that can be implanted into the body.…”

Section: Icvd Polymer Propertiesmentioning

confidence: 99%

“…One strategy for drug release uses coating of a drug a stable permselective polymer For this approach, the release rate is controlled by the diffusion of the drug across the thickness of the polymer layer. Using iCVD, polymer layers can be produced at thicknesses ranging from <10 nm to >100 μm (Gleason, 2020a ). Additionally, the iCVD method provides the ability to grow layers free of pinholes.…”

Section: Icvd Polymer Propertiesmentioning

confidence: 99%

“…In some cases, the polymer layer erodes or dissolves away, introducing a time delay before the encapsulated drug is released at a rate comparable to the uncoated drug (Shi et al, 2018 ). In other situations, the polymer layer remains and presents a permeation barrier to slow the diffusion of therapeutic molecules from the encapsulated drug reservoir (Coclite, 2013 ; Gleason, 2020a ). In the case where the polymer layer remains, the drug molecules contained in the encapsulated reservoir must diffuse through the polymer layer before being released in the body.…”

Section: Introductionmentioning

confidence: 99%

“…The iCVD process brings nanoscale control to polymer thin film synthesis. Using controlled iCVD growth rates allows the formation of pinhole-free films as thin as 10 nm (Gleason, 2020a , b ). Alternatively, utilizing processing conditions that result in high deposition rates allows iCVD film thicknesses of 1,000 nm or more to be deposited in a reasonable period (Shi et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Gleason

2021

Front. Bioeng. Biotechnol.

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This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release.

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Section: Icvd Polymer Composition and Designmentioning

confidence: 99%

Section: Icvd Polymer Propertiesmentioning

confidence: 99%

Section: Icvd Polymer Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Gleason

2021

Front. Bioeng. Biotechnol.

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Diverse Polymer Nanomembranes Toward Task‐Specific Applications

Zhu¹,

Wu²,

Cui³

et al. 2022

Nanomembranes

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Optimizing the Optoelectronic Properties of Face‐On Oriented Poly(3,4‐Ethylenedioxythiophene) via Water‐Assisted Oxidative Chemical Vapor Deposition

Gharahcheshmeh

Robinson

Gleason

et al. 2020

Adv Funct Materials

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Engineering the texture and nanostructure to improve the electrical conductivity of semicrystalline conjugated polymers must address the rate-limiting step for charge carrier transport. In highly face-on orientation, the charge transport between chains within a crystallite becomes rate-limiting, which is highly sensitive to the π-π stacking distance and interchain charge transfer integral. Here, face-on oriented semicrystalline poly(3,4-ethylenedioxythiophene) (PEDOT) thin films are grown via water-assisted (W-A) oxidative chemical vapor deposition (oCVD). Combining W-A with the volatile oxidant, antimony pentachloride, yields an optimized electrical conductivity of 7520 ± 240 S cm −1 , a record for PEDOT thin films. Systematic control of π-π stacking distance from 3.50 Å down to 3.43 Å yields an electrical conductivity enhancement of ≈1140%. The highest electrical conductivity also corresponds to minimum in Urbach energy of 205 meV, indicating superior morphological order. The figure of merit for transparent conductors, σ dc /σ op , reaches a maximum value of 94, which is 1.9× and 6.7× higher than oCVD PEDOT grown without W-A and utilizing vanadium oxytrichloride and iron chloride oxidizing agents, respectively. The W-A oCVD is single-step all-dry process and provides conformal coverage, allowing direct growth on mechanical flexible, rough, and structured surfaces without the need for complex and costly transfer steps.

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Chemically vapor deposited polymer nanolayers for rapid and controlled permeation of molecules and ions

Abstract: The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. CitationGleason, Karen K. "Chemically vapor deposited polymer nanolayers for rapid and controlled permeation of molecules and ions."

Cited by 18 publications

References 118 publications

Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Diverse Polymer Nanomembranes Toward Task‐Specific Applications

Optimizing the Optoelectronic Properties of Face‐On Oriented Poly(3,4‐Ethylenedioxythiophene) via Water‐Assisted Oxidative Chemical Vapor Deposition

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