Chemicals isolated from <i>Justicia adhatoda</i> Linn reduce fitness of the mosquito, <i>Aedes aegypti</i> L

Thanigaivel, Annamalai; Senthil-Nathan, Sengottayan; Vasantha-Srinivasan, Prabhakaran; Edwin, Edward-Sam; Ponsankar, Athirstam; Selin-Rani, Selvaraj; Pradeepa, Venkatraman; Chellappandian, Muthiah; Kalaivani, Kandaswamy; Abdel-Megeed, Ahmed; Narayanan, R. Ram; Murugan, Kadarkarai

doi:10.1002/arch.21384

Cited by 35 publications

(20 citation statements)

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“…Many previous research outcomes proved alteration or inhibition in the expression of major detoxifying enzymes exposed to plant chemicals. Thanigaivel et al (2017a) showed increase in the rate of GST activity in IV instar larvae of dengue mosquito exposed to methanolic leaf extract of J. adhatoda with their major derivative 3-hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1h) one (26.37%). Likewise, carboxylesterase activities differed significantly in Ae.…”

Section: Impact Of Phytochemicals On Detoxifying Enzymesmentioning

confidence: 99%

“…A study conducted on testing the mosquitocidal activity of Justicia adhatoda L. (Acanthaceae) leaf extracts revealed the potential of natural larvicidal agent against Ae. Aegypti (Thanigaivel et al, 2012(Thanigaivel et al, , 2017a.…”

Section: Biological Management Of Mosquitoesmentioning

confidence: 99%

“…Besides exhibiting larvicidal activity Alangium salvifolium, also substantially reduced the levels of α, β-carboxylesterase as well as superoxide dismutase (SOD) in Ae. Aegypti (Thanigaivel et al, 2017a). Myrrh commiphora molmol (oil and oleo-resin extract) instigated biochemical changes in Cx.…”

Section: Impact Of Phytochemicals On Detoxifying Enzymesmentioning

confidence: 99%

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A Review of Resistance Mechanisms of Synthetic Insecticides and Botanicals, Phytochemicals, and Essential Oils as Alternative Larvicidal Agents Against Mosquitoes

Senthil‐Nathan

2020

Front. Physiol.

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174

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Mosquitoes are a serious threat to the society, acting as vector to several dreadful diseases. Mosquito management programes profoundly depend on the routine of chemical insecticides that subsequently lead to the expansion of resistance midst the vectors, along with other problems such as environmental pollution, bio magnification, and adversely affecting the quality of public and animal health, worldwide. The worldwide risk of insect vector transmitted diseases, with their associated illness and mortality, emphasizes the need for effective mosquitocides. Hence there is an immediate necessity to develop new eco-friendly pesticides. As a result, numerous investigators have worked on the development of eco-friendly effective mosquitocidal compounds of plant origin. These products have a cumulative advantage of being cost-effective, environmentally benign, biodegradable, and safe to non-target organisms. This review aims at describing the current state of research on behavioral, physiological, and biochemical effects of plant derived compounds with larvicidal effects on mosquitoes. The mode of physiological and biochemical action of known compounds derived from various plant families as well as the potential of plant secondary metabolites, plant extracts, and also the essential oils (EO), as mosquitocidal agents are discussed. This review clearly indicates that the application of vegetal-based compounds as mosquito control proxies can serve as alternative biocontrol methods in mosquito management programes.

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Section: Impact Of Phytochemicals On Detoxifying Enzymesmentioning

confidence: 99%

Section: Biological Management Of Mosquitoesmentioning

confidence: 99%

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A Review of Resistance Mechanisms of Synthetic Insecticides and Botanicals, Phytochemicals, and Essential Oils as Alternative Larvicidal Agents Against Mosquitoes

Senthil‐Nathan

2020

Front. Physiol.

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174

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“…It is essential to gage the primary and secondary impact of any forms of pesticides upon non-target species [26,31,51]. Toxorhynchites are an excellent predator against the dengue larvae 'Aedes' and are measured to be not hurtful to their well-beings and well-fixed as they are non-blood feeders and considered to be a good biological predator for reducing the populations of blood-sucking mosquitoes [52].…”

Section: Discussionmentioning

confidence: 99%

“…The prepared enzyme homogenates were prepared based on our previous research [15] and kept on ice for further enzyme assays. Furthermore, enzyme estimations of carboxylesterase (α and β), SOD, glutathione S-transferase (GST), and CYP450 were analyzed based on the adapted methodology of Thanigaivel et al [26].…”

Section: Enzyme Assaysmentioning

confidence: 99%

Target Activity of Isaria tenuipes (Hypocreales: Clavicipitaceae) Fungal Strains against Dengue Vector Aedes aegypti (Linn.) and Its Non-Target Activity Against Aquatic Predators

Sengodan

Vasantha-Srinivasan

Ganesan

et al. 2020

JoF

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The present investigation aimed to determine the fungal toxicity of Isaria tenuipes (My-It) against the dengue mosquito vector Aedes aegypti L. and its non-target impact against the aquatic predator Toxorhynchitessplendens. Lethal concentrations (LC50 and LC90) of My-It were observed in 2.27 and 2.93 log ppm dosages, respectively. The sub-lethal dosage (My-It-1 × 104 conidia/mL) displayed a significant oviposition deterrence index and also blocked the fecundity rate of dengue mosquitos in a dose-dependent manner. The level of major detoxifying enzymes, such as carboxylesterase (α-and β-) and SOD, significantly declined in both third and fourth instar larvae at the maximum dosage of My-It 1 × 105 conidia/mL. However, the level of glutathione S-transferase (GST) and cytochrome P-450 (CYP450) declined steadily when the sub-lethal dosage was increased and attained maximum reduction in the enzyme level at the dosage of My-It (1 × 105 conidia/mL). Correspondingly, the gut-histology and photomicrography results made evident that My-It (1 × 105 conidia/mL) heavily damaged the internal gut cells and external physiology of the dengue larvae compared to the control. Moreover, the non-target toxicity against the beneficial predator revealed that My-It at the maximum dosage (1 × 1020 conidia/mL) was found to be less toxic with <45% larval toxicity against Tx.splendens. Thus, the present toxicological research on Isaria tenuipes showed that it is target-specific and a potential agent for managing medically threatening arthropods.

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Toxicological effects of chemical constituents from Piper against the environmental burden Aedes aegypti Liston and their impact on non-target toxicity evaluation against biomonitoring aquatic insects

Vasantha-Srinivasan

Thanigaivel

Edwin

et al. 2017

Environ Sci Pollut Res

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Dengue is the most rapidly spreading mosquito-borne viral disease in the world. The mosquito, Aedes aegypti, also spreads Yellow fever, Chikungunya, and Zika virus. As the primary vector for dengue, Ae. aegypti now occurs in over 20 countries and is a serious concern with reports of increasing insecticide resistance. Developing new treatments to manage mosquitoes are needed. Formulation of crude volatile oil from Piper betle leaves (Pb-CVO) was evaluated as a potential treatment which showed larvicidal, ovipositional, and repellency effects. Gut-histology and enzyme profiles were analyzed post treatment under in-vitro conditions. The Pb-CVO from leaves of field collected plants was obtained by steam distillation and separated through rotary evaporation. The Pb-CVO were evaluated for chemical constituents through GC-MS analyses revealed 20 vital compounds. The peak area was establish to be superior in Eudesm-7(11)-en-4-ol (14.95%). Pb-CVO were determined and tested as four different concentrations (0.25, 0.5, 1.0, and 1.5 mg/L) of Pb-CVO towards Ae. aegypti. The larvicidal effects exhibited dose dependent mortality being greatest at 1.5 mg Pb-CVO/10 g leaves. The LC occurred at 0.63 mg Pb-CVO/L. Larva of Ae. aegypti exposed to Pb-CVO showed significantly reduced digestive enzyme actions of α- and β-carboxylesterases. In contrast, GST and CYP450 enzyme levels increased significantly as concentration increased. Correspondingly, oviposition deterrence index and egg hatch of Ae. aegypti exposed to sub-lethal doses of Pb-CVO demonstrated a strong effect suitable for population suppression. Repellency at 0.6 mg Pb-CVO applied as oil had a protection time of 15-210 min. Mid-gut histological of Ae. aegypti larvae showed severe damage when treated with 0.6 mg of Pb-CVO treatment compared to the control. Non-toxic effects against aquatic beneficial insects, such as Anisops bouvieri and Toxorhynchites splendens, were observed at the highest concentrations, exposed for 3 h. These results suggest that the Pb-CVO may contain effective constituents suitable for development of new vector control agents against Ae. aegypti.

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Chemicals isolated from Justicia adhatoda Linn reduce fitness of the mosquito, Aedes aegypti L

Cited by 35 publications

References 35 publications

A Review of Resistance Mechanisms of Synthetic Insecticides and Botanicals, Phytochemicals, and Essential Oils as Alternative Larvicidal Agents Against Mosquitoes

A Review of Resistance Mechanisms of Synthetic Insecticides and Botanicals, Phytochemicals, and Essential Oils as Alternative Larvicidal Agents Against Mosquitoes

Target Activity of Isaria tenuipes (Hypocreales: Clavicipitaceae) Fungal Strains against Dengue Vector Aedes aegypti (Linn.) and Its Non-Target Activity Against Aquatic Predators

Toxicological effects of chemical constituents from Piper against the environmental burden Aedes aegypti Liston and their impact on non-target toxicity evaluation against biomonitoring aquatic insects

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