Chemiluminescence of creatinine/H2O2/Co2+ and its application for selective creatinine detection

Hanif, Saima; John, Peter; Gao, Wenyue; Saqib, Muhammad; Qi, Liming; Xu, Guobao

doi:10.1016/j.bios.2015.08.053

Cited by 68 publications

(26 citation statements)

References 47 publications

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“…Creatine is a nitrogenous organic acid, which is synthesized primarily in liver from the methylation of glycocyamine by S-adenosyl methionine [ 47 ]. It is then transported through the blood to the other organs, where phosphorylation occurred [ 48 ]. Creatinine is formed from creatine, which is a waste product for the body.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats

Pei

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Niuhuang Jiedu Tablet (NJT) is a classical formula in treating acute tonsillitis, pharyngitis, and so on. In the formula, significant level of Realgar as a potentially toxic element is contained. Our previous experiments revealed that it was less toxic for combined Realgar in NJT. However, the active fraction of this prescription with toxicity alleviation effect on Realgar was still obscure. NJT was divided into five different polar fractions (NJT-PET, NJT-25, NJT-50, NJT-75, and NJT-95), and we explored the toxicity alleviation effect on Realgar. Based on 1H NMR spectra of urine and serum from rats, PCA and PLS-DA were performed to identify different metabolic profiles. Liver and kidney histopathology examinations and serum clinical chemistry analysis were also performed. With pattern recognition analysis of metabolites in urine and serum, Realgar group showed a clear separation from control group, while the metabolic profiles of NJT-PET, NJT-25, NJT-50, and NJT-95 groups were similar to Realgar group, and the metabolic profiles of NJT and NJT-75 groups were very close to control group. Statistics results were confirmed by the histopathological examination and biochemical assay. The present work indicated that 75% EtOH fraction of NJT was the most valid fraction with the toxicity alleviation effect on Realgar.

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Section: Discussionmentioning

confidence: 99%

Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats

Pei

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…For example, Hanif et al reported that creatinine can generate chemiluminescence when reacting with hydrogen peroxide and the reaction is remarkably enhanced in the presence of cobalt ions. 95 Using this phenomenon and a flow mixing microfluidic device, they developed a chemiluminescence creatinine sensor with a LOD of 0.07 µM and linear range of 0.1–30 µM, which is much more sensitive than most reported methods and the commercial PoC sensors. They validated this method by detection of creatinine in human urine samples and the test took less than 1 min.…”

Section: Loc Systems For Ckd Diagnosismentioning

confidence: 99%

Lab-on-chip technology for chronic disease diagnosis

et al. 2018

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Various types of chronic diseases (CD) are the leading causes of disability and death worldwide. While those diseases are chronic in nature, accurate and timely clinical decision making is critically required. Current diagnosis procedures are often lengthy and costly, which present a major bottleneck for effective CD healthcare. Rapid, reliable and low-cost diagnostic tools at point-of-care (PoC) are therefore on high demand. Owing to miniaturization, lab-on-chip (LoC) technology has high potential to enable improved biomedical applications in terms of low-cost, high-throughput, ease-of-operation and analysis. In this direction, research toward developing new LoC-based PoC systems for CD diagnosis is fast growing into an emerging area. Some studies in this area began to incorporate digital and mobile technologies. Here we review the recent developments of this area with the focus on chronic respiratory diseases (CRD), diabetes, and chronic kidney diseases (CKD). We conclude by discussing the challenges, opportunities and future perspectives of this field.

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“…Creatinine levels in serum and urine can be used as a biomarker for monitoring the deteriorated kidney function and the effect of treatment in hemodialysis patients [5]. Normal range of creatinine is between 40 to 150 μ M in serum and 2.48 to 22.92 mM in urine [6, 7]. If high uric acid levels in serum are persistently found, total uric acid excretion may be needed to estimate the kidney function by two 24-hour urine collections for monitoring uric acid excretion and creatinine clearance.…”

Section: Introductionmentioning

confidence: 99%

Disposable Nonenzymatic Uric Acid and Creatinine Sensors Using μPAD Coupled with Screen-Printed Reduced Graphene Oxide-Gold Nanocomposites

Income

Ratnarathorn

Khamchaiyo

et al. 2019

International Journal of Analytical Chemistry

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Uric acid (UA) and creatinine are the imperative biological substance for clinical monitoring and diagnosis. Measuring the ratio between uric acid and creatinine in urine helps differentiate acute uric acid nephropathy from the hyperuricemia that secondarily occurs to renal failure. In general, the ratio is greater than 0.9 in acute uric acid nephropathy and less than 0.7 in hyperuricemia. In this work, disposable nonenzymatic screen-printed reduced graphene oxide-gold nanocomposites electrodes were firstly developed for the quantitative analysis of uric acid. Our sensors were also coupled with the paper-based colorimetric sensor of the determination of creatinine. Hence, an alternative high-throughput screening test for the uric acid to creatinine ratio with high sensitivity, specificity, simplicity, and rapidity was developed. Under the optimum conditions, our disposable nonenzymatic screen-printed electrode for the determination of uric acid shows the acceptable analytical performance in a wide range of linearity (2.5-1,000 μM) with a low detection limit of 0.74 μM. Our electrodes also showed no interference from common physiologic compound in urine. The determination of creatinine has been developed using Jaffé reaction between the creatinine and picric acid in alkaline condition. The alkaline picrate color on μPAD changed from yellow to orange in the presence of creatinine and the orange intensity is directly proportional to the creatinine amount in a linearity range of 0.20-6.0 mM as a detection limit of 180 μM. Finally, our device has been utilized to determine uric acid and creatinine simultaneously in control urine samples with acceptable result.

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Chemiluminescence of creatinine/H2O2/Co2+ and its application for selective creatinine detection

Cited by 68 publications

References 47 publications

Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats

Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats

Lab-on-chip technology for chronic disease diagnosis

Disposable Nonenzymatic Uric Acid and Creatinine Sensors Using μPAD Coupled with Screen-Printed Reduced Graphene Oxide-Gold Nanocomposites

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