Chemiluminescence of neutrophils from patients with Behçet's disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora

Isogai, Emiko; Ohno, Shigeaki; Kotake, Satoshi; Isogai, Hiroshi; Tsurumizu, Takashi; Fujii, Nobuhiro; Yokota, K.; Syuto, Bunei; Yamaguchi, M.; Matsuda, Hidehiko; Oguma, Keiji

doi:10.1016/0003-9969(90)90113-o

Cited by 86 publications

(48 citation statements)

References 13 publications

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“…Microbial heat shock proteins (HSPs) show significant homology with human mitochondrial HSP and molecular mimicry is suggested as the mechanism of pathology exacerbating BD when patients were exposed to these foreign antigens. While both streptococci and herpes simplex virus have garnered the most particular interest among researchers [209][210][211][212][213][214], evidence of exposure to other microbes such as staphylococci and mycobacteria has also been reported [215,216]. Nonetheless, conflicting reports have been published and a specific pathogen has yet to be identified.…”

Section: The Host-microbe Interaction In Bdmentioning

confidence: 99%

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Adeeb¹,

Khan²,

Stack³

et al. 2017

Behcet's Disease

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Behçet's disease (BD) is a type of vasculitis with many distinctive clinical manifestations and multifactorial immunopathogenesis. The cause of BD remains unknown, but it has been postulated that in a genetically predisposed or susceptible population, exogenous agents trigger the dysregulation of both autoinflammatory and autoimmune responses resulting in multisystem vasculitis. There are robust ongoing efforts across the globe to elucidate and identify signature markers to improve and assist in rapid diagnosis of the disease and to tailor the best therapy accordingly. While association of human leukocyte antigen (HLA)-B * 51 (B * 51:01 subtype) allele is well recognized as the strongest genetic susceptibility gene so far among genetically predisposed BD patients, further investigations using the latest technology have led to the identification of several novel single nucleotide polymorphisms (SNPs) and other associated genes involved in the pathogenesis. There are several "established" cytokines known to be involved in the pathogenesis of BD, which have been further implicated in the genome-wide association studies (GWAS)-based cytokine/receptor gene loci studies, as well as numerous "novel" cytokines, which are currently being studied and identified. This chapter offers insights into current knowledge and thoughts regarding the future of biomarkers in BD.

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Section: The Host-microbe Interaction In Bdmentioning

confidence: 99%

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Adeeb¹,

Khan²,

Stack³

et al. 2017

Behcet's Disease

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“…However, it is not possible to isolate any organism that emerged consistently. In some studies, streptococcus was found in high concentrations in the oral flora of patients with Behcet's disease which we thought played a role in the occurrence of oral aphthous lesions, the first symptom in Behcet's disease [6][7][8]. In addition, the intense hypersensitivity reaction to streptococcal strains was thought to play a role in the symptoms of Behcet's disease patients.…”

Section: Introductionmentioning

confidence: 99%

Antistreptolysin O Levels in Patients with Behcet’s Disease

Uzkeser¹,

Karatay²,

Yıldırım³

et al. 2011

EAJM

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Objective: Behcet's disease is a multisystem inflammatory disorder, and its etiology has not been defined clearly yet. In this study, we aimed to investigate the antistreptolysin O (ASO) levels of patients with Behcet's disease. Materials and Methods:Thirty patients with Behcet's disease and 30 healthy controls were enrolled in this study. We measured erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), and ASO levels in both groups.Results: There was no statistically significant difference between the two groups with respect to demographic data (p>0.05). The ASO levels of the patients and the controls were 288.4±145.7 and 170.6±142.4 ng/ml, respectively. In the patients with Behcet's disease, ASO (p<0.01) and ESR (p<0.05) values were significantly higher than in the healthy controls. There was no other significant difference in serum CRP levels between the patients and the controls. We could not find any correlation among ASO, CRP, and ESR values. Conclusion:Our results suggest that serum ASO levels may increase in patients with Behcet's disease. Further studies are needed in order to define the relationship between ASO levels and inflammation status in Behcet's disease. Sonuç: Bizim sonuçlarımıza göre Behçet hastalarında serum ASO seviyeleri yüksek olabilir. Behçet hastalarında ASO düzeyleri ve inflamasyon kaskadı arasındaki ilişkiyi belirlemek için yeni çalışmalara ihtiyaç duyulmaktadır.

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“…Generally, the oral health is impaired in BD patients with the disease severity [11][12][13]15,16] . The antibodies against S. sanguinis showed cross reactivity with the synthetic peptides of HSP-65 derived from the There are some reports that BD patients associated with HLA-B51 show much stronger reaction to "Pathergy test".…”

Section: Hypersensitivity Against S Sanguinismentioning

confidence: 99%

“…The proportion of Streptococcus sanguinis (S. sanguinis), which was previously recognized as species of the genus Streptococcus named "S. sanguis", was significantly high in the oral bacterial flora of BD patients in comparison with those of healthy controls. S. sanguinis from BD patients was identified as uncommon serotype KTH-1 (so-called by the bacterial and enzymatic properties [14][15][16] . Most of BD patients tend to acquire hypersensitivity against streptococci in their oral flora, as previously demonstrated that the cutaneous reactions by the injection and/or prickle with bacteria antigens of streptococci and enterococci were much stronger than the reaction by "Pathergy test".…”

Section: Introductionmentioning

confidence: 99%

“…Although the actual etiology of BD is still unclear, the pathogenesis has been generally clearer by the etiological studies based on the genetic intrinsic factors and extrinsic triggering factors [5][6][7][8][9][10][11][12][13][14][15][16] . As one of the triggering factors, the oral unhygienic condition may be suspected, because periodontitis, decayed teeth, chronic tonsillitis, etc.…”

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confidence: 99%

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Behcet’s Disease and Related Diseases -Immune Reactions to Oralstreptococci in Their Pathogenesis

Kaneko

Togashi

Nomura

et al. 2016

Journal of Dermatological Research

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the retinal protein Brn3b which might be connected with the eye involvement in BD patients. Also, the peptides seem to be homologous with HSP-65 in association with the human HSP-60 which reactively appeared in serum of the patients involved by S. sanguinis.Then, the pathogenesis of BD was conclusively discussed on the relationship between RAS and the systemic symptoms by the vascular reaction due to immune responses against antigens derived from S. sanguinis. Non-BD patients with RAS and/or Lipschutz genital ulceration were weekly sensitized by oral streptococci, except for patients with EN. [2][3][4] .Although the actual etiology of BD is still unclear, the pathogenesis has been generally clearer by the etiological studies based on the genetic intrinsic factors and extrinsic triggering factors [5][6][7][8][9][10][11][12][13][14][15][16] . As one of the triggering factors, the oral unhygienic condition may be suspected, because periodontitis, decayed teeth, chronic tonsillitis, etc. are frequently noted in BD patients [12,13] . The proportion of Streptococcus sanguinis (S. sanguinis), which was previously recognized as species of the genus Streptococcus named "S. sanguis", was significantly high ABSTRACTBehçet's disease (BD) is a systemic disorder characterized by the recurrent involvement in the muco-cutaneous, ocular, intestinal, vascular, and/or nervous system organs. The clinical muco-cutaneous manifestations including recurrent aphthous stomatitis (RAS), erythema nodosum (EN) -like eruption, genital ulceration, etc. of patients with BD were reviewed in their pathogenesis comparing with the similar symptoms seen in patients without BD (non-BD). Most of BD patients tend to have hypersensitivity against streptococci which might be acquired in the oral cavity through the innate immune mechanism. Generally, BD patients have the systemic symptoms following RAS symptom as an immune reaction. Then, the characteristics of hypersensitivity to oral streptococci may be utilized in order to make a diagnosis for BD. The skin prick with self-saliva including oral streptococci was much more sensitive than "Pathergy test" conventionally used for BD diagnosis. HLA-B51-restricted CD8+ T cell response is suspected to catch the target tissues expressing major histocompatibility complex class 1 chain-related gene A (MICA) by stress in active BD patients. Bes-1 gene and 65kD of heat shock protein (HSP-65) derived from Streptococcus sanguinis (S. sanguinis) are detectable in the lesions. The peptides of Bes-1 gene are highly homologous with REVIEW

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Chemiluminescence of neutrophils from patients with Behçet's disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora

Cited by 86 publications

References 13 publications

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Antistreptolysin O Levels in Patients with Behcet’s Disease

Behcet’s Disease and Related Diseases -Immune Reactions to Oralstreptococci in Their Pathogenesis

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