ChemInform Abstract: 1,2,3‐Triazole Derivatives as New Cannabinoid CB1 Receptor Antagonists.

Abstract

Triazole derivatives R 0280 1,2,3-Triazole Derivatives as New Cannabinoid CB1 Receptor Antagonists. -With a view to their potential biological activity, compounds such as (IV) and (VIII) are prepared. Among them some derivatives, e.g. (VIIIb) and (VIIIc), inhibit CB1 with an IC50 value less than 20nM having a high CB2 selectivity (some yields not given).-(HOU*, D.-R.; ALAM, S.; KUAN, T.-C.; RAMANATHAN, M.; LIN, T.-P.; HUNG, M.-S.; Bioorg. Med.