ChemInform Abstract: 1,5‐DIAZABICYCLO(3.3.0)OCTADIENEDIONES (9,10‐DIOXABIMANES). STRONGLY FLUORESCENT SYN ISOMERS

Abstract

Aus 4‐Chlor‐pyrazolonen‐(5) (I) entstehen unter der Einwirkung von Basen wie K2CO3 bei Raumtemp. syn‐ (II) und anti‐Isomere (III) der Titelverbindungen; unsymm. Verbindungen dieses Typs erhält man z.B. ausgehend von äquimolaren (Ia)‐(Ib)‐Gemischen.

Alkaloid-Catalyzed Enantioselective [3 + 2] Cycloaddition of Ketenes and Azomethine Imines

“…1 Some examples include anti-Alzheimer’s disease molecule 1 and related bicyclic pyrazolidinone derivatives that exhibit herbicidal, pesticidal, and antibiotic activity (Scheme 1). 1 However, the catalytic asymmetric synthesis of pyrazolidinones of structure 1 has proven an elusive target.…”

“…1 Some examples include anti-Alzheimer’s disease molecule 1 and related bicyclic pyrazolidinone derivatives that exhibit herbicidal, pesticidal, and antibiotic activity (Scheme 1). 1 However, the catalytic asymmetric synthesis of pyrazolidinones of structure 1 has proven an elusive target. 2 Enantioselective access to pyrazolidinone motifs could be envisaged through a chiral catalyst-controlled 1,3-dipolar cycloaddition of an azomethine imine with a suitable dipolarophile reactant partner.…”

Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye

“…[8][9][10] As a potential scaffold for such amyloid dyes, bimane is a highly attractive structure to its small size and relatively low toxicity. [11][12][13][14][15][16][17] Bimane was introduced by Kosower and coworkers nearly four decades ago, 13,14 , and is widely used for in vitro protein labeling as cysteine-reactive monobromobimane (Scheme 1, 2). 12,[15][16][17] However, there have been some applications in cells, and it has been shown that a syn-bimane adduct of a-aminobutyric acid can cross the blood-brain barrier in rodents.…”

Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] Pathways

“…Tetrahydropyrazolopyrazolones have been investigated as antibacterial agents, 16 herbicides, pesticides, 20 antitumor agents, 21 calcitonin agonists, 22 and potent drugs to relieve Alzheimer’s disease. 23 Pyrazolopyridazinone derivatives have been studied extensively as pesticides and, especially, herbicides; more than 60 patents have been filed according to the CAS database. Pyrazolodiazepinone and pyrazolodiazocinone derivatives have also been explored as herbicides, insecticides, acaricides, 24 and acetyl-CoA carboxylase inhibitors.…”