ChemInform Abstract: 1‐Hydroxy‐2‐methyl‐2‐propyl Isocyanide (HMPI) as a New Convertible Isocyanide for the Ugi Four‐Component‐Coupling Reaction.

Abstract

1-Hydroxy-2-methyl-2-propyl Isocyanide (HMPI) as a New Convertible Isocyanide for the Ugi Four-Component-CouplingReaction. -The successful use of isocyanide (IV) in Ugi four-component reactions is shown. The mild chemoselective cleavage of the resulting N-(1-hydroxy-2-methyl-2-propyl) amides is achieved by alcoholysis mediated by Zn(OTf)2 and diethyl carbonate. -(OIKAWA*, M.; SUGAMATA, Y.; CHIBA, M.; FUKUSHIMA, K.; ISHIKAWA, Y.; Synlett 24 (2013) 15, 2014-2018, http://dx.