ChemInform Abstract: 3‐(Dimethylamino)‐1‐propylamine: A Cheap and Versatile Reagent for Removal of Byproducts in Carbohydrate Chemistry.

Abstract

Chemistry. -3-(dimethylamino)-1-propylamine is used as reagent for selective anomeric deacylation in carbohydrate chemistry to give 1-O deprotected sugars in high yields without chromatographic purification. The crude reaction mixture is washed with HCl to remove the byproducts. The lactol (II) can be used in one-pot reaction to provide glycosyl trichloroacetimidate (VI). -(ANDERSEN, S. M.; HEUCKENDORFF, M.; JENSEN*, H. H.; Org. Lett. 17 (2015) 4, 944-947, http://dx.doi.org/10.1021/acs.orglett.5b00041 ; Dep. Chem., Aarhus Univ., DK-8000 Aarhus, Den.; Eng.) -B. Mosebach 28-257