ChemInform Abstract: 4‐(3‐Methoxyphenyl)‐1‐substituted‐4H‐[1,2,4]triazolo [4,3‐a]quinazolin‐5‐ones: New Class of H₁‐Antihistaminic Agents.

Abstract

Fused pyrimidine derivatives R 0515 4-(3-Methoxyphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones: New Class of H 1 -Antihistaminic Agents. -Compound (IXb), which is the most active antihistaminic agent, exhibits more potent activity compared to the standard drug chlorpheniramine maleate among negligible sedation and may serve as a lead molecule for further modification. -(ALAGARSAMY*, V.; SHARMA, H. K.; PARTHIBAN, P.; SINGH, J. C. H.; MURUGAN, S. T.; SOLOMON, V. R.; Pharmazie 64 (2009) 1, 5-9; Med. Chem. Res. Lab., MNR Coll. Pharm., Fasalwadi, Sangareddy 502 294, India; Eng.) -K. Woydowski

Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

“…It has been reported as antimicrobial [1e7], antiviral [8], anti-HIV [9], anticonvulsant [10,11], antiinflammatory [12e14], antihistaminic [15], anti-tubercular [16,17], and anticancer [18,19] activity, etc. A huge number of quinazolines had been synthesized and evaluated for various activities however their antiviral activity was not fully investigated to a greater extent.…”

Comparative Studies of Interactions between Fluorodihydroquinazolin Derivatives and Human Serum Albumin with Fluorescence Spectroscopy

“…Heterocyclic structures play a pivotal role in many pharmaceutical, agrochemical, and veterinary products, like quinazolines. An increasing number of quinazoline derivatives have been reported to possess antibacterial [15], anticancer [16], antitubercular [17], anti-HIV [18], antifungal [19], analgesic [20], anti-inflammatory [21], anticonvulsant [22], antiparkinson [23], anthelmintic [24], anti-histaminic [25], and antihypertensive activities [26]. Much attention has been focused on their structures and bioactivity.…”