ChemInform Abstract: 5,6,7,8‐Tetrahydropyrido[4,3‐c]pyridazine: A Lead‐Oriented Scaffold with Two Diversity Points.

Abstract

5,6,7,8-Tetrahydropyrido[4,3-c]pyridazine: A Lead-Oriented Scaffold with Two Diversity Points. -The five step sequence for the synthesis of the title compounds includes the reaction of 4-piperidone derivative (I) with glyoxylic acid and hydrazine as the key step. -(BORISOV, A. V.; VOLOSHCHUK, V. V.; NECHAYEV, M. A.; GRYGORENKO*, O. O.; Synthesis 45 (2013) 17, 2413-2416, http://dx.doi.org/10.1055/s-0033-1339325 ; Taras Shevchenko Natl. Univ., Kiev 01601, Ukraine; Eng.) -Mais 05-156