ChemInform Abstract: 5‐Fluorouracil Derivatives. Part 12. Synthesis and Antitumor Activity of α‐Alkylthiomethyl‐, α‐Alkylsulfinylmethyl‐, α‐Alkylsulfonylmethyl‐, and α‐Acylthiomethyl‐5‐fluorouracils.

Abstract

The 5‐fluorouracil derivatives (III) ‐ (V), (VIII), and (X) with sulfur‐containing side groups are prepared as outlined in the reaction scheme.

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation

“…No further reaction was observed when sulfoxides 9-10 were treated with excess hydrogen peroxide. Heating with sodium periodate in water [31] resulted in a nonselective nucleobase oxidation. A similar result was achieved when the Oxone in methanol method [32] was employed.…”