ChemInform Abstract: 5‐Methylflavasperone and Rhamnetin from Guiera senegalensis and Their Antioxidative and 5‐Lipoxygenase Inhibitory Activity.

Bučar, Franz; Resch, M.; Bauer, Rudolf; Burits, M.; Knauder, E.; Schubert‐Zsilavecz, Manfred

doi:10.1002/chin.199913289

Cited by 7 publications

(6 citation statements)

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“…Par ailleurs, à partir de l'extrait de chlorure de méthylène des feuilles de G. senegalensis un nouveau naphtopyrane, la 5méthylflavaspérone (5,8,10-triméthoxy-2méthyl-4H-naphto [1,2-b]pyran-4-one), ainsi que la rhamnétine ont été isolés (Bucar et al, 1999).…”

Section: Composition Chimiqueunclassified

Revue bibliographique sur la composition chimique et les activités biologiques de <i>Guiera senegalensis</i> J.F. Gmel. (Combretaceae)

Tine¹,

Diop²,

Ndoye³

et al. 2020

Int. J. Bio. Chem. Sci

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Cette étude avait pour objectif de faire le point sur la composition chimique et les activités biologiques de G. senegalensis, une plante médicinale largement utilisée en Afrique par les guérisseurs traditionnels pour le traitement de divers troubles. La plupart de ces études chimiques ont porté sur le criblage phytochimique des extraits de feuilles, de racines, de tiges et de galles. Elles ont montré la présence d'hydrates de carbone, de stéroïdes, de saponines, de flavonoïdes, d’alcaloïdes, de tanins, de saponines, de glycosides cardiaques, de coumarines, d’anthraquinones, d’acide ascorbique, d’hétérosides cardiotoniques, de cyanogènes et de terpénoïdes. Les potentialités thérapeutiques des extraits de G. senegalensis rapportées dans plusieurs travaux scientifiques ont porté sur les activités antibactériennes, antitussives, antidiarrhéiques, cytotoxiques, anti-inflammatoires antipaludiques, antitrypanosomiques, antihelminthiques, antivirales et antioxydantes. Des études de toxicité sur ces extraits ont été aussi réalisées. Ainsi, des études de caractérisation chimique (variabilité chimique), de formulation galénique et aussi de toxicité clinique sur G. senegalensis doivent être menées afin de mettre en place des produits de phytothérapie moderne.Mots clés: Phytochimie, pharmacologie, feuilles, Guiera senegalensis. English Title: Review on the chemical composition and biological activities of Guiera senegalensis J.F. Gmel. (Combretaceae)The aim of this study was to review the chemical composition and biological activities of G. senegalensis, a medicinal plant widely used in Africa by traditional healers for the treatment of various disorders. Most of these chemical studies have focused on the phytochemical screening of leaf, root, stem and gall extracts. They showed the presence of carbohydrate, steroids, saponins, flavonoids, alkaloids, tannins, saponins, cardiac glycosides, coumarins, anthraquinones, ascorbic acid, cardiotonic glycosides, cyanogens and terpenoids. The therapeutic potentialities of extracts of G. senegalensis reported in several scientific studies have focused on antibacterial, antitussive, antidiarrheal, cytotoxic, anti-inflammatory, antimicrobial, antitrypanosomal, anthelmintic, antiviral and antioxidant activities. Toxicity studies on these extracts have also been carried out. Thus, chemical characterization studies (chemical variability), galenic formulation and clinical toxicity studies on G. senegalensis must be carried out in order to implement modern phytotherapy products.Keywords: Phytochemistry, pharmacology, leaves, Guiera senegalensis.

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Section: Composition Chimiqueunclassified

Revue bibliographique sur la composition chimique et les activités biologiques de <i>Guiera senegalensis</i> J.F. Gmel. (Combretaceae)

Tine¹,

Diop²,

Ndoye³

et al. 2020

Int. J. Bio. Chem. Sci

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“…Anti-inflammatory properties of these extracts were assessed by their ability to inhibit 5-lipoxygenases [94, 370, 371] or cyclooxygenase (COX-1 and COX-2) activities [65, 275, 317, 372, 373]. Using the former [374] and the latter [264, 331] methodologies, respectively, a great number of South African medicinal plant extracts were screened for their anti-inflammatory properties.…”

Section: Tests Used To Assess Antioxidant Activities Of African Mementioning

confidence: 99%

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment

Gulumian

Yahaya

Steenkamp

2018

Evidence-Based Complementary and Alternative Medicine

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The use of traditional herbal remedies as alternative medicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological levels of free radicals are essential to the healing process, they are known to partly contribute to wound chronicity when in excess. Consequently, antioxidant therapy has been shown to facilitate healing of such wounds. Also, a growing body of evidence suggests that, at least, part of the therapeutic value of herbals may be explained by their antioxidant activity. This paper reviews African herbal remedies with antioxidant activity with the aim of indicating potential resources for wound treatment. Firstly, herbals with identified antioxidant compounds and, secondly, herbals with proven antioxidant activity, but where the compound(s) responsible for the activity has not yet been identified, are listed. In the latter case it has been attempted to ascribe the activity to a compound known to be present in the plant family and/or species, where related activity has previously been documented for another genus of the species. Also, the tests employed to assess antioxidant activity and the potential caveats thereof during assessment are briefly commented on.

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“…The leaves are also used as a poultice on tumours and against the Guinea worm (Berhaut, 1967). Besides these uses in traditional medicine, some extracts of this plant have been found to possess pharmacological properties: antimicrobial (Le Grand, 1989;Bosisio et al, 1997;Sanogo et al, 1998), antifungal (Silva and Elsa, 2003) and antioxidant (Bucar et al, 1998;Bouchet, 1998). Therefore, the present was to determine the phytochemical and antibacterial activity of Guiera senegalensis among some selected species of gram positive and gram negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical And Antibacterial Activityof Leave Extracts Of Guiera Senegalensis Lam On Selected Species Of Gram Positive And Gram Negative Bacteria

Mamman

Isa

2013

Int. J. Environ.

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The aim of this study was to determine the preliminary phytochemical component and antibacterial activity of the leaves extract of Guiera senegalensis lam (Combretaceae) against three clinical isolates (Staphylococcus aureus, E. coli and Klebsiella species) using standard method of analysis. The test for phytochemical component revealed the presence of alkaloid, anthraquinolones, tannin and phlobatanins. The result of antibacterial activity showed that the ethanolic extract exhibit higher zone of inhibition against all the clinical isolates, with E. coli and Klebsiella species showed zone of inhibition of 35mm followed Staphylococcus aureus 30mm. Similarly, both aqueous and methanolic extract were sensitive to all the clinical isolate except Klebsiella species which showed resistance to the methanolic extract of the leaves. The results obtained in this research imply that the leaves extract of Guiera senegalensis lam could be useful in the treatment of infections caused by Staphylococcus aureus, E. coli and Klebsiella species.

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ChemInform Abstract: 5‐Methylflavasperone and Rhamnetin from Guiera senegalensis and Their Antioxidative and 5‐Lipoxygenase Inhibitory Activity.

Cited by 7 publications

References 0 publications

Revue bibliographique sur la composition chimique et les activités biologiques de <i>Guiera senegalensis</i> J.F. Gmel. (Combretaceae)

Revue bibliographique sur la composition chimique et les activités biologiques de <i>Guiera senegalensis</i> J.F. Gmel. (Combretaceae)

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment

Phytochemical And Antibacterial Activityof Leave Extracts Of Guiera Senegalensis Lam On Selected Species Of Gram Positive And Gram Negative Bacteria

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