ChemInform Abstract: A Convenient Synthesis of d‐Sotalol.

Abstract

diastereoselective syntheses, enantioselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans-isomerism) O 0031 20 -027 A Convenient Synthesis of d-Sotalol. -A new and simple route for the synthesis of both the antiarrhythmic drugs d-Nifenanlol (V) and d-Sotalol (VIII) using the Sharpless asymmetric dihydroxylation of 4-nitrostyrene (I) followed by regiospecific opening of chiral cyclic sulfate (III) with isopropylamine (IV) as key steps is accomplished. -(PHUKAN, PRODEEP; JAGTAP, H. S.; SUDALAI, A.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 39 (2000) 12, 950-953; Div. Process Dev., Natl. Chem. Lab., Pune 411 008, India; EN)

Ordered Mesoporous and Microporous Molecular Sieves Functionalized with Transition Metal Complexes as Catalysts for Selective Organic Transformations

“…Detailed study of catalyst stability has shown that in proper reaction conditions, Cu leaching can be limited to levels that are irrelevant to homogeneous catalysis. In addition to aziridination, similar Cu-zeolites have found application in the amination of silyl enol ethers with PhIN-Ts to form α-aminoketones 38 …”