ChemInform Abstract: A Detailed Investigation into the Oxidation Mechanism of Hantzsch 1,4‐Dihydropyridines by Ethyl α‐Cyanocinnamates and Benzylidenemalononitriles.

Abstract

A Detailed Investigation into the Oxidation Mechanism of Hantzsch 1,4-Dihydropyridines by Ethyl α-Cyanocinnamates and Benzylidenemalononitriles. -Correlation analyses on kinetics, kinetic isotope effects, and activation parameters confirm the one-step hydride transfer mechanism, proposed for the oxidation of Hantzsch ester (I) by α,β-unsaturated esters or nitriles (IIa) or (IIb) to form Hantzsch pyridine (III) in quantitative yield. -