ChemInform Abstract: A Facile Horner—Wadsworth—Emmons Route to 2‐Quinolones.

Abstract

Pyridine derivatives R 0380A Facile Horner-Wadsworth-Emmons Route to 2-Quinolones. -A convenient method for the synthesis of the target compounds involves N-acylation of o-aminophenylketones with phosphonoalkanoyl chlorides followed by intramolecular Horner-Wadsworth-Emmons olefination. Amides derived from the α-unsubstituted phosphono acid (XVI) give Knoevenagel products [cf. (XVIII)]. -(PETERS*, J.-U.; CAPUANO, T.; WEBER, S.; KRITTER, S.; SAEGESSER, M.; Tetrahedron Lett. 49 (2008) 25, 4029-4032; Pharma Div., Discovery Chem., F. Hoffmann-La Roche AG, CH-4070 Basel, Switz.; Eng.) -Mais 40-140