ChemInform Abstract: A General Approach to the Asymmetric Synthesis of Lignans: (‐)‐Methyl Piperitol, (‐)‐Sesamin, (‐)‐Aschantin, (+)‐Yatein, (+)‐Dihydroclusin, (+)‐Burseran, and (‐)‐Isostegane.

Abstract

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TRIP-Catalyzed Asymmetric Synthesis of (+)-Yatein, (−)-α-Conidendrin, (+)-Isostegane, and (+)-Neoisostegane

“…In order to further expand the portfolio of lignan natural products available within short synthetic procedures we envisaged the other classes of compounds herein. The first targets demonstrate the cyclooctadienes isostegane [14][15][16][17][18][19][20][21] and neoisostegane [22][23][24] (5 and 6, see Figure 2). Stegane natural products show a high potential as pharmacophores, as they provide strong inhibition of the tubulin assembly, 25 a process of high importance in the treatment of cancer.…”