ChemInform Abstract: A McMurry Route to the Dienediyne Portion of Models of the Neocarzinostatin Chromophore.

Abstract

A McMurry Route to the Dienediyne Portion of Models of the Neocarzinostatin Chromophore. -Key step in the synthesis of the title compounds (IV) is the intramolecular McMurry coupling of dicarbonyls (III) which are prepared via a Sonogashira-Thoda-Hagihara coupling of intermediate (I) with iodo cyclohexenone. (I) is obtained using established methods in alkyne chemistry. Model (IVa) undergoes cycloaromatization by the Saito-Myers mode on reaction with methyl thioglycolate. -(RANK, E.; BRUECKNER, R.; Eur.