ChemInform Abstract: A NEW SOFT IONIZATION TECHNIQUE FOR MASS SPECTROMETRY OF COMPLEX MOLECULES

High-Throughput and Direct Sample Screening Using a Laser Spray Ionization Miniature Mass Spectrometer

“…Mini mass spectrometers for both volatile and nonvolatile sample analyses have been developed. − Besides portability, a miniature mass spectrometer is also expected to be operated by rudimentarily trained or even untrained personnel, especially for in situ analyses. Miniaturized gas chromatography (GC) mass spectrometers have been commercialized and applied for the analyses of volatile organic compounds (VOC) in air or water. − However, the handling of nonvolatile samples is usually more complex, and tedious sample pretreatment procedures may be needed before MS analysis. − This problem was greatly relieved by the coupling of ambient ionization techniques , with miniature mass spectrometers. With minimum sample pretreatments, it has been demonstrated that complex and even biological samples could be directly analyzed by the application of ambient ionization sources with miniature mass spectrometers. , …”