ChemInform Abstract: A New Taraxastane‐Type Triterpene from Vitex trifolia var. simplicifolia

Huang, Mingyu; Zhong, Lin-Jing; Xie, Jianping; Wang, Fei; Zhang, Yonghong

doi:10.1002/chin.201415219

Cited by 4 publications

(5 citation statements)

References 1 publication

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“…VF Carbonisata samples differed considerably. Peaks 2,4,5,8,14,19,23,24,27,29,30,32,34,35,40,43, and 46 were absent, while peaks 20, 21, 22, 44, and 45 were new. Additionally, peak 33 in the VF Carbonisata sample was significantly higher than in other samples.…”

Section: Resultsmentioning

confidence: 96%

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An Integrated Strategy to Qualitatively Differentiate Components of Raw and Processed Viticis Fructus Based on NIR, HPLC and UPLC-MS Analysis

et al. 2018

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Viticis Fructus is a traditional Chinese herbal drug processed by various methods to achieve different clinical purposes. Thermal treatment potentially alters chemical composition, which may impact on effectiveness and toxicity. In order to interpret the constituent discrepancies of raw versus processed (stir-fried) Viticis Fructus, a multivariate detection method (NIR, HPLC, and UPLC-MS) based on metabonomics and chemometrics was developed. Firstly, synergy interval partial least squares and partial least squares-discriminant analysis were employed to screen the distinctive wavebands (4319 - 5459 cm) based on preprocessed near-infrared spectra. Then, HPLC with principal component analysis was performed to characterize the distinction. Subsequently, a total of 49 compounds were identified by UPLC-MS, among which 42 compounds were eventually characterized as having a significant change during processing via the semiquantitative volcano plot analysis. Moreover, based on the partial least squares-discriminant analysis, 16 compounds were chosen as characteristic markers that could be in close correlation with the discriminatory near-infrared wavebands. Together, all of these characterization techniques effectively discriminated raw and processed products of Viticis Fructus. In general, our work provides an integrated way of classifying Viticis Fructus, and a strategy to explore discriminatory chemical markers for other traditional Chinese herbs, thus ensuring safety and efficacy for consumers.

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Section: Resultsmentioning

confidence: 96%

“…9). [26], 27 (luteolin) [24], 28 (quercetin) [26], 30 (penduletin) [8], 31 (casticin) [27,28], 32 (isoorientin) [20], 33 (agnuside) [29], 34 (ursolic acid) [30], and 35 (betulinic acid) [24] in the negative mode were lower in VF Carbonisata samples than in raw samples ( Table S5, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

An Integrated Strategy to Qualitatively Differentiate Components of Raw and Processed Viticis Fructus Based on NIR, HPLC and UPLC-MS Analysis

et al. 2018

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“…Artemetin and casticin (Fig. 3) have been identified from ethanolic extracts of dried fruits of V. trifolia [45,46] and methanolic extracts of dried leaves and twigs of V. trifolia [17]. Both artemetin and casticin are reported to have potent lipoxygenase inhibition, with casticin two times more potent than artemetin [47].…”

Section: Discussionmentioning

confidence: 99%

“…The roots are used as antiemetic, expectorant and believed to help relieve fever [13,14]. Several phytochemicals reported in the leaf extracts of V. trifolia include flavonoids, such as casticin [15], vitexin [16] and luteolin [17], and terpenes such as eucalyptol and caryophyllene [18]. A number of studies have been published on the anti-inflammatory effects of V. trifolia leaf extracts using various rat experimental models, such as Carrageenan induced paw edema rat model [19][20][21][22], and RAW264.7 mouse cell lines induced with lipopolysaccharide [10,11,23].…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Wee

Neo

Singh

et al. 2020

BMC Complement Med Ther

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Background: Dysregulation of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) form the basis of immune-mediated inflammatory diseases. Vitex trifolia L. is a medicinal plant growing in countries such as China, India, Australia and Singapore. Its dried ripe fruits are documented in Traditional Chinese Medicine to treat ailments like rhinitis and dizziness. Its leaves are used traditionally to treat inflammation-related conditions like rheumatic pain. Objective: This study aimed to investigate the effects of V. trifolia leaf extracts prepared by different extraction methods (Soxhlet, ultrasonication, and maceration) in various solvents on cytokine production in human U937 macrophages, and identify phytoconstituents from the most active leaf extract. Methods: Fresh leaves of V. trifolia were extracted using Soxhlet, ultrasonication, and maceration in hexane, dichloromethane, methanol, ethanol or water. Each extract was evaluated for its effects on TNF-α and IL-1β cytokine production by enzyme-linked immunosorbent assay in lipopolysaccharide-stimulated human U937 macrophages. The most active extract was analyzed and further purified by different chemical and spectroscopic techniques. Results: Amongst 14 different leaf extracts investigated, extracts prepared by ultrasonication in dichloromethane and maceration in ethanol were most active in inhibiting TNF-α and IL-1β production in human U937 macrophages. Further purification led to the isolation of artemetin, casticin, vitexilactone and maslinic acid, and their effects on TNF-α and IL-1β production were evaluated. We report for the first time that artemetin suppressed TNF-α and IL-1β production. Gas chromatography-mass spectrometry analyses revealed the presence of eight other compounds. To the best of our knowledge, this is the first report of butylated hydroxytoluene, 2,4-di-tertbutylphenol, campesterol and maslinic acid in V. trifolia leaf extracts.

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“…Betuna spp (birch tree) is one of betulinic acid sources, from which the acid is most frequently discovered and excessively obtained (Ghaffari, et al,2012). From Vitexgenus, betulinic acid is found in Vitex negundo plant (Zheng, et al,2010) and Vitex trifolia (Huang, et al, 2013). The compounds in phydroxybenzoate acid were previously isolated from the stem bark of Vitex negundo (Dhakal, et al, 2008(Dhakal, et al, /2009.…”

Section: H29mentioning

confidence: 99%

Structure Elucidation of an Pentacyclic Triterpenoid and Phenolic from Steam Bark of Vitex Pubescens Vahl

Anwar¹

2019

JCNaR

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ChemInform Abstract: A New Taraxastane‐Type Triterpene from Vitex trifolia var. simplicifolia

Cited by 4 publications

References 1 publication

An Integrated Strategy to Qualitatively Differentiate Components of Raw and Processed Viticis Fructus Based on NIR, HPLC and UPLC-MS Analysis

An Integrated Strategy to Qualitatively Differentiate Components of Raw and Processed Viticis Fructus Based on NIR, HPLC and UPLC-MS Analysis

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Structure Elucidation of an Pentacyclic Triterpenoid and Phenolic from Steam Bark of Vitex Pubescens Vahl

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