ChemInform Abstract: Acanthopanax senticosus: Review of Botany, Chemistry and Pharmacology

Huang, Linzhang; Zhao, HongFang; Huang, Bao‐Kang; Zheng, Cheng‐Jian; Peng, Wei; Qin, Lu-Ping

doi:10.1002/chin.201125219

Cited by 78 publications

(111 citation statements)

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“…It is considered to be an adaptogen and is chiefly exploited for strengthening the spleen and kidney. 10,11 Eleutherosides, the major bioactive compounds found in E. senticosus, are phenylpropanoids, lignin glycosides that occur abundantly in the roots and stems. 12 E. senticosus has been proven to possess anticancer, 13 antioxidant, and antimicrobial activities.…”

mentioning

confidence: 99%

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Abbai¹,

Mathiyalagan²,

Markus³

et al. 2016

IJN

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Pharmacologically active stem of the oriental herbal adaptogen, Siberian ginseng, was employed for the ecofriendly synthesis of Siberian ginseng silver nanoparticles (Sg-AgNPs) and Siberian ginseng gold nanoparticles (Sg-AuNPs). First, for metabolic characterization of the sample, liquid chromatography-tandem mass spectrometry analysis (indicated the presence of eleutherosides A and E), total phenol content, and total reducing sugar were analyzed. Second, the water extract of the sample mediated the biological synthesis of both Sg-AgNPs and Sg-AuNPs that were crystalline face-centered cubical structures with a Z-average hydrodynamic diameter of 126 and 189 nm, respectively. Moreover, Fourier transform infrared analysis indicated that proteins and aromatic hydrocarbons play a key role in the formation and stabilization of Sg-AgNPs, whereas phenolic compounds accounted for the synthesis and stability of Sg-AuNPs. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay determined that Sg-AgNPs conferred strong cytotoxicity against MCF7 (human breast cancer cell line) and was only slightly toxic to HaCaT (human keratinocyte cell line) at 10 µg⋅mL −1 . However, Sg-AuNPs did not display cytotoxic effects against both of the cell lines. The disc diffusion assay indicated a dose-dependent increase in the zone of inhibition of Staphylococcus aureus (ATCC 6538), Bacillus anthracis (NCTC 10340), Vibrio parahaemolyticus (ATCC 33844), and Escherichia coli (BL21) treated with Sg-AgNPs, whereas Sg-AuNPs did not show inhibitory activity. In addition, the 2,2-diphenyl-1-picrylhydrazyl assay demonstrated that both Sg-AgNPs and Sg-AuNPs possess strong antioxidant activity. To the best of our knowledge, this is the first report unraveling the potential of Eleutherococcus senticosus for silver and gold nanoparticle synthesis along with its biological applications, which in turn would promote widespread usage of the endemic Siberian ginseng.

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mentioning

confidence: 99%

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Abbai¹,

Mathiyalagan²,

Markus³

et al. 2016

IJN

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“…2, 4-Dichlorophenoxy acetic acid C 2 H 4 Ethylene CO 2 Carbon dioxide DW Dry weight FW Fresh weight GA 3 Gibberellic acid MJ Methyl jasmonate MS medium Murashige and Skoog medium O 2 Oxygen vvm Air volume per medium volume per minute…”

Section: Abbreviations 2 4-dmentioning

confidence: 99%

“…It is distributed in southeast Russia, Northeastern China, Korea and Japan [ 1 , 2 ]. This plant is used in traditional Chinese medicine as an adaptogen and to strengthen spleen and kidney [ 3 ]. It is popular in other parts of the world as an health supplement and recorded as a pharmacopeial species in monographs of European Pharmacopoeia and American Herbal Pharmacopoeia.…”

Section: Introductionmentioning

confidence: 99%

Production of Bioactive Compounds from Somatic Embryo Suspension Cultures of Siberian Ginseng in Bioreactors

Shohael

Khatun

Murthy

et al. 2014

Production of Biomass and Bioactive Compounds Using Bioreactor Technology

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Eleutherococcus senticosus (Rupr. & Maxim.) Maxim ( Acanthopanax senticosus ), popularly known as 'Siberian ginseng', is a woody medicinal plant which is used in traditional medicine as an adaptogen. It is marketed throughout the world as a health supplement. The major active ingredients are lignan glycosides called eleutherosides. Efforts have been made recently to produce bioactive compounds from suspension cultures of somatic embryos. Bioreactor cultures have been established for the production of embryogenic biomass and bioactive compounds. In this review, we have presented bioreactor scale production of bioactive compounds and explained various bioprocess strategies for the production of eleutheroside B, E, E1 and chlorogenic acid.

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“…It has traditionally been used as a folk medicine to treat acute rheumatism, hydroncus, hypopiesia and chloasma in China. The roots and stems of A. senticosus exhibit antiinflammatory (Leem et al, 2014), anti-diabetic (Park et al, 2013), hepatoprotective (Choi et al, 2006), anti-oxidant (Lu et al, 2012), hypocholesterolemic (Huang et al, 2011), and other such activities. Previous chemical studies of A. senticosus revealed the presence of triterpene saponins (Li et al, 2007;Jiang et al, 2006), aromatic glycosides (Li et al, 2009), lignans (Deyama et al, 2011), and ceramides (Yan et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity

Lee

Zhang

et al. 2015

Phytochemistry Letters

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ChemInform Abstract: Acanthopanax senticosus: Review of Botany, Chemistry and Pharmacology

Abstract: Acanthopanax senticosus: Review of Botany, Chemistry and Pharmacology -[98 refs.]. -(HUANG, L.; ZHAO, H.; HUANG, B.; ZHENG, C.; PENG, W.; QIN*, L.; Pharmazie 66 (2011) 2, 83-97, http://dx.

Cited by 78 publications

References 0 publications

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Production of Bioactive Compounds from Somatic Embryo Suspension Cultures of Siberian Ginseng in Bioreactors

Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity

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